Nox4 Promotes Endothelial Differentiation Through Chromatin Remodeling
Redox Biology, 2022 Rationale: Nox4 is a constitutively active NADPH oxidase that constantly produces low levels of H2O2. Thereby, Nox4 contributes to cell homeostasis and long-term processes, such as differentiation.
S Günther
exaly +4 more sources
Tubular NOX4 Expression Decreases in Chronic Kidney Disease but Does Not Modify Fibrosis Evolution
Redox Biology, 2019 Background: NADPH oxidase 4 (NOX4) catalyzes the formation of hydrogen peroxide (H2O2). NOX4 is highly expressed in the kidney, but its role in renal injury is unclear and may depend on its specific tissue localization.
Pidder Jansen-Duerr +2 more
exaly +4 more sources
Oxidation of HDAC4 by Nox4-Derived H2O2 Maintains Tube Formation by Endothelial Cells
Redox Biology, 2020 NADPH oxidases produce reactive oxygen species that differ in localization, type and concentration. Within the Nox family only Nox4 produces H2O2 which can directly oxidize cysteine residues. With this post-translational modification, activity, stability,
Anna Gajos-Draus +2 more
exaly +3 more sources
Redox Biology, 2019 M2-type tumor-associated macrophages (TAMs) infiltration contributes to cancer malignant progression. However, the mechanisms for controlling recruitment and M2 polarization of macrophages by cancer cells are largely unclear.
Bing Liu, Luyong Zhang, Zhicheng Yang
exaly +3 more sources
From Form to Function: The Role of Nox4 in the Cardiovascular System
Frontiers in Physiology, 2012 The NADPH oxidase (Nox) family of proteins is comprised of 7 members, including Noxes 1-5 and the Duoxes 1 and 2. Nox4 is readily distinguished from the other Nox isoforms by its high level of expression in cardiovascular tissues and unique enzymatic ...
David Fulton +2 more
exaly +3 more sources
Role of apigenin in high glucose-induced retinal microvascular endothelial cell dysfunction via regulating NOX4/p38 MAPK pathway in vitro [PDF]
International Journal of Ophthalmology, 2023 AIM: To investigate the retinoprotective role of Apigenin (Api) against high glucose (HG)-induced human retinal microvascular endothelial cells (HRMECs), and to explore its regulatory mechanism.
Li-Li Liu, Zhi-Yi Zhao
doaj +1 more source
RNA interference targeting NOX4 protects visual function in an experimental model of retinal detachment by alleviating blood-retinal barrier damage [PDF]
International Journal of Ophthalmology, 2021 AIM: To observe the effects of the inhibition of NADPH oxidase 4 (NOX4) expression on the retinal vascular barriers and visual function after retinal detachment (RD).
Kai Dong +5 more
doaj +1 more source
Decreased Cardiac NOX4 and SIRT-1 Protein Levels Contribute to Decreased Angiogenesis in the Heart of Diabetic Rats: Rescue Effects of IGF-1 and Exercise [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: Reduced angiogenesis in the heart tissue is a primary risk factor for heart disease in the diabetes condition. This study was aimed to evaluate the changes of two main angiogenesis mediators, NADPH oxidase 4 (NOX4) and sirtuin 1 (SIRT-1) protein
Shiva Roshan Milani +3 more
doaj +1 more source
Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression [PDF]
Annals of Geriatric Medicine and Research, 2020 Background Sestrin2 (Sesn2) is involved in the maintenance of metabolic homeostasis and aging via modulation of the 5' AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) pathway.
Chae Young Hwang +5 more
doaj +1 more source
High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway
Biology Open, 2021 Podocytes are the major target in proteinuric kidney diseases such as diabetic nephropathy. The underlying molecular mechanisms by which high glucose (HG) results in podocyte damage remain unclear.
Wanxu Guo +4 more
doaj +1 more source