Results 11 to 20 of about 23,054 (234)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression [PDF]

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +2 more sources

Regulation of Monocyte Adhesion and Migration by Nox4 [PDF]

PLoS ONE, 2013
We showed that metabolic disorders promote thiol oxidative stress in monocytes, priming monocytes for accelerated chemokine-induced recruitment, and accumulation at sites of vascular injury and the progression of atherosclerosis. The aim of this study was to identify both the source of reactive oxygen species (ROS) responsible for thiol oxidation in ...
Chi Fung Lee, Sarah Ullevig, Hong Seok Kim, Reto Asmis   +3 more
openaire   +5 more sources

Role of the TSPO–NOX4 axis in angiogenesis in glioblastoma

Frontiers in Pharmacology, 2022
Objective: Angiogenesis is a pathological feature of glioblastoma. Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is a vital source of reactive oxygen species (ROS) related to angiogenesis.
Hongxiang Jiang, Hongxiang Jiang, Fei Li, Fei Li, Linzhi Cai, Qianxue Chen   +5 more
doaj   +3 more sources

NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice [PDF]

Redox Biology, 2021
Liver is a unique organ in displaying a reparative and regenerative response after acute/chronic damage or partial hepatectomy, when all the cell types must proliferate to re-establish the liver mass.
M. Herranz-Itúrbide, J. López-Luque, E. Gonzalez-Sanchez, D. Caballero-Díaz, E. Crosas-Molist, B. Martín-Mur, M. Gut, A. Esteve-Codina, V. Jaquet, J.X. Jiang, N.J. Török, I. Fabregat   +11 more
doaj   +2 more sources

Role of Nox4 in murine models of kidney disease

Free Radical Biology and Medicine, 2012
Nox4 is a hydrogen peroxide-producing NADPH oxidase highly expressed in the kidney which has been linked to epithelial cell injury and diabetic-induced cellular dysfunction in cultured cells. The role of the enzyme for renal pathology in vivo, however, is unclear.
Babelova, Andrea, Avaniadi, Despina, Jung, Oliver, Fork, Christian, Beckmann, Janet, Kosowski, Judith, Weissmann, Norbert, Anilkumar, Narayana, Shah, Ajay M., Schaefer, Liliana, Schroeder, Katrin, Brandes, Ralf P.   +11 more
openaire   +4 more sources

NOX4-mediated astrocyte ferroptosis in Alzheimer’s disease

Cell & Bioscience
AbstractThis study investigates NADPH oxidase 4 (NOX4) involvement in iron-mediated astrocyte cell death in Alzheimer’s Disease (AD) using single-cell sequencing data and transcriptomes. We analyzed AD single-cell RNA sequencing data, identified astrocyte marker genes, and explored biological processes in astrocytes.
Yasenjiang Maimaiti, Ting Su, Zhanying Zhang, Lingling Ma, Yuan Zhang, Hong Xu   +5 more
openaire   +4 more sources

Strategies Aimed at Nox4 Oxidase Inhibition Employing Peptides from Nox4 B-Loop and C-Terminus and p22phox N-Terminus: An Elusive Target [PDF]

International Journal of Hypertension, 2013
Although NADPH oxidase 4 (Nox4) is the most abundant Nox isoform in systemic vascular endothelial and smooth muscle cells, its function in the vascular tissue is not entirely known.
Gábor Csányi, Patrick J. Pagano
doaj   +2 more sources

NOX4–TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming

Journal of Biological Chemistry, 2023
Pulmonary fibrosis is a progressive lung disease characterized by macrophage activation. Asbestos-induced expression of nicotinamide adenine dinucleotide phosphate hydrogen oxidase 4 (NOX4) in lung macrophages mediates fibrotic progression by the generation of mitochondrial reactive oxygen species (ROS), modulating mitochondrial biogenesis, and ...
Jyotsana Pandey, Jennifer L. Larson-Casey, Mallikarjun H. Patil, Rutwij Joshi, Chun-sun Jiang, Yong Zhou, Chao He, A. Brent Carter   +7 more
openaire   +2 more sources

The Radioprotective Effect of Magnesium Sulfate and Vitamin A on Radiation-induced Micronuclei and the Expression of NOX4 in Bone Marrow Cells of Mice [PDF]

Journal of Kerman University of Medical Sciences, 2022
Background: Radioprotectors are used to neutralize the effects of free radicals caused by ionization radiation. In this study, the radioprotective effects of magnesium sulfate and vitamin A on bone marrow cells of mice were evaluated by micronucleus ...
Mohammad Mirdoraghi, Vahid Changizi, Seyed Abolghasem Haeri, Zahra Rajabi, Peyman Amini, Sakineh Abassi   +5 more
doaj   +1 more source

Vascular Nox4 [PDF]

Circulation Research, 2012
Nox4, one of the 7 isoforms of the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase family that generate reactive oxygen species, was first identified in the early 2000s in kidneys.1 Nox4 was originally described as an oxygen sensor and regulator of kidney cell growth and because of its renal abundance was termed “renox.”1 It soon became ...
Touyz, R.M., Montezano, A.C.
openaire   +3 more sources