Results 31 to 40 of about 23,054 (234)
Cell Death Discovery, 2022 Advanced differentiated thyroid cancer cells are subjected to extreme nutritional starvation which contributes to develop resistance to treatments; however, the underlying mechanism remains unclear. Cells were subjected to serum deprivation by culture in
Ping Tang +8 more
doaj +1 more source
CRISPR-Cas9 Mediated NOX4 Knockout Inhibits Cell Proliferation and Invasion in HeLa Cells. [PDF]
PLoS ONE, 2017 Increased expression of NOX4 protein is associated with cancer progression and metastasis but the role of NOX4 in cell proliferation and invasion is not fully understood.
Naser Jafari +7 more
doaj +1 more source
Adipocyte, 2020 Nonalcoholic fatty liver disease (NAFLD), main cause of liver damage, is inextricably linked to diabetes. However, there is no specific means to improve the pathology of fatty liver in diabetic patients.
Ping Li +9 more
doaj +1 more source
NADPH oxidase 4 deficiency attenuates experimental osteoarthritis in mice
RMD Open, 2023 Objective Low-grade inflammation plays a pivotal role in osteoarthritis (OA) through exposure to reactive oxygen species (ROS). In chondrocytes, NADPH oxidase 4 (NOX4) is one of the major ROS producers.
Felix Renaudin +9 more
doaj +1 more source
Nox4-SH3YL1 Complex Is Involved in Diabetic Nephropathy
iScience, 2023 Nox4-derived H2O2 generation plays an important role in the pathogenesis of chronic kidney diseases (CKDs) such as diabetic nephropathy (DN). Here, we showed that SH3 domain-containing Ysc84-like 1 (SH3YL1), a Nox4 cytosolic activator, regulated DN. Streptozotocin (STZ)-induced type Ⅰ diabetic models in SH3YL1 whole-body knockout (KO) mice and podocyte-
Sae Rom Lee +7 more
openaire +3 more sources
Nox4 expression in osteo-progenitors controls bone development in mice during early life [PDF]
, 2022 Tightly regulated and cell-specific NADPH-oxidases (Nox) represent one of the major sources of reactive oxygen species (ROS) signaling molecules that are involved in tissue development and stem cell self-renewal. We have characterized the role of Nox4 in
Schroder, Katrin +20 more
core +1 more source
Nox4 is a Target for Tuberin Deficiency Syndrome
Scientific Reports, 2018 AbstractThe mechanism by which TSC2 inactivation or deficiency contributes to the pathology of tuberous sclerosis complex (TSC) is not fully clear. We show that renal angiomyolipomas from TSC patients and kidney cortex from Tsc2+/− mice exhibit elevated levels of reactive oxygen species (ROS). Downregulation of tuberin (protein encoded by TSC2 gene) in
Qian Shi +8 more
openaire +3 more sources
NADPH oxidase 4 signaling in a ventilator-induced lung injury mouse model
Respiratory Research, 2022 Background For patients with acute respiratory distress syndrome, a ventilator is essential to supply oxygen to tissues, but it may also cause lung damage.
Sang Hoon Lee +6 more
doaj +1 more source
NOX4 mRNA correlates with plaque stability in patients with carotid artery stenosis
Redox Biology, 2022 Carotid artery stenosis (CAS) develops from atherosclerotic lesions and plaques. Plaque rupture or stenosis may result in occlusion of the carotid artery.
Anja Hofmann +15 more
doaj +1 more source
Functional Role of Nox4 in Autophagy
, 2017 Accumulating lines of evidence suggest that reactive oxygen species (ROS) may act as intracellular signaling molecules under cellular stress conditions, activating several molecular pathways. Autophagy, the intracellular mechanism by which cells digest and recycle unfolded proteins and dysfunctional organelles, is emerging as a major target of ROS and ...
Forte, Maurizio +4 more
openaire +3 more sources