Results 21 to 30 of about 23,054 (234)

Chronic Exposure to Fluoride Affects GSH Level and NOX4 Expression in Rat Model of This Element of Neurotoxicity

Biomolecules, 2020
Exposure of neural cells to harmful and toxic factors promotes oxidative stress, resulting in disorders of metabolism, cell differentiation, and maturation.
Karolina Dec, Agnieszka Łukomska, Karolina Skonieczna-Żydecka, Karolina Jakubczyk, Maciej Tarnowski, Anna Lubkowska, Irena Baranowska-Bosiacka, Daniel Styburski, Marta Skórka-Majewicz, Dominika Maciejewska, Izabela Gutowska   +10 more
doaj   +1 more source

SIRT1-NOX4 Signaling Axis Regulates Cancer Cachexia [PDF]

, 2020
Approximately one third of cancer patients die due to complexities related to cachexia. However, the mechanisms of cachexia and the potential therapeutic interventions remain poorly studied.
Hollingsworth, M.A., Pacheco, C.G., Punsoni, M., Chaika, N.V., Sadoshima, J., Rai, I., Klute, K.A., Abrego, J., Shukla, S.K., Murthy, D., King, R.J., Thakur, R., Attri, K.S., Mulder, S.E., Graves, G., Dasgupta, A., Grandgenett, P. M., Singh, P.K., Mullen, N.J., Teoh-Fitzgerald, M., Zimmerman, M.C., Oberley-Deegan, R., Wang, D., Mehla, K., Buettner, K., Engle, D. D., Yu, F., Tuveson, D. A., Vernucci, E., Reames, B.N.   +29 more
core   +3 more sources

Subcellular localization of Nox4 and regulation in diabetes [PDF]

Proceedings of the National Academy of Sciences, 2009
Oxidative stress is implicated in human diseases. Some of the oxidative pathways are harbored in the mitochondria. NAD(P)H oxidases have been identified not only in phagocytic but also in somatic cells. Nox4 is the most ubiquitous of these oxidases and is a major source of reactive oxygen species (ROS) in many cell types and in ...
Karen, Block, Yves, Gorin, Hanna E, Abboud   +2 more
openaire   +2 more sources

Image1_Role of the TSPO–NOX4 axis in angiogenesis in glioblastoma.tif

, 2022
Objective: Angiogenesis is a pathological feature of glioblastoma. Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is a vital source of reactive oxygen species (ROS) related to angiogenesis.
Linzhi Cai (11893250), Hongxiang Jiang (9189806), Qianxue Chen (1806181), Fei Li (143236)   +3 more
core   +1 more source

Table1_Role of the TSPO–NOX4 axis in angiogenesis in glioblastoma.xls

, 2022
Objective: Angiogenesis is a pathological feature of glioblastoma. Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is a vital source of reactive oxygen species (ROS) related to angiogenesis.
Linzhi Cai (11893250), Hongxiang Jiang (9189806), Qianxue Chen (1806181), Fei Li (143236)   +3 more
core   +1 more source

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration [PDF]

, 2010
Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of the patients.
Shah, Ajay M., Sven G. Meuth, de Angelis, MH, Henrike Grund, Schmidt, HHHW, Grund, Henrike, Schuhmann, M.K., Hrabě de Angelis, M., Sabine Meurer, Schrewe, A., Stoll, G., Peter Kraft, Martin Hrabé de Angelis, Barit, David, Barit, D., Schwarz, Tobias, de Angelis, Martin Hrabe, Stoll, Guido, Shah, AM, Klopstock, T., Weissmann, N, Schrewe, A, Mittal, M, Herrmann, A.M., Jones, Emma, Konstanze Barthel, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Kraft, Peter, Becker, L., Fuchs, H, Jandeleit-Dahm, Karin, Anja Schrewe, Harald H. H. W, Herrmann, AM, David Barit, Sven G Meuth, Meurer, S., Weissmann, Norbert, Schmidt, H.H., Michael K. Schuhmann, Kraft, P., Schuhmann, Michael K., Weissmann, N., Meuth, SG, Schwarz, T, Karin Jandeleit-Dahm, Barthel, Konstanze, Herrmann, Alexander M., Stoll, G, Meurer, Sabine, Schmidt, Harald H. H. W., Guido Stoll, Wingler, K., Christian Geis, Mittal, Manish, Lore Becker, Schrewe, Anja, Klopstock, Thomas, Fuchs, Helmut, Shah, A.M., Jandeleit-Dahm, K, Gailus-Durner, V, Barthel, K., Ajay M. Shah, Klopstock, T, Manish Mittal, Armitage, Melanie E., Meuth, S.G., Norbert Weissmann, Harald H. H. W. Schmidt, Kraft, P, Michael K Schuhmann, Hrabe ́ De Angelis, Grund, H, Meuth, Sven G., Jones, E., Thomas Klopstock, Geis, C, Schuhmann, MK, Tobias Schwarz, Grund, H., Kleinschnitz, Christoph, Melanie E Armitage, Barthel, K, Meurer, S, Kleinschnitz, C, Fuchs, H., Armitage, ME, Kleinschnitz, C., Kirstin Wingler, Valérie Gailus-Durner, Geis, Christian, Geis, C., Jones, E, Karin J, Gailus-Durner, V., Emma Jones, Becker, L, Jandeleit-Dahm, Karin A., Wingler, Kirstin, Helmut Fuchs, Mittal, M., Schwarz, T., Armitage, M.E., Er M. Herrmann, Jandeleit-Dahm, K., Harald H H W Schmidt, Becker, Lore, Ajay M Shah, Christoph Kleinschnitz, Alexander M. Herrmann, Wingler, K, Alexander M Herrmann, Melanie E. Armitage, Barit, D, Kraft Peter, Mittal Manish, Klopstock Thomas, Meurer Sabine, Schwarz Tobias, Jones Emma, Schuhmann Michael K., Barit David, Barthel Konstanze, Geis Christian, Schmidt Harald H. H. W., de Angelis Martin Hrabé, Fuchs Helmut, Kleinschnitz Christoph, Armitage Melanie E., Kleinschnitz, C. ; Grund, H. ; Wingler, K. ; Armitage, M.E. ; Jones, E. ; Mittal, M. ; Barit, D. ; Schwarz, T. ; Geis, C. ; Kraft, P. ; Barthel, K. ; Schuhmann, M.K. ; Herrmann, A.M. ; Meuth, S.G. ; Stoll, G. ; Meurer, S. ; Schrewe, A. ; Becker, L. ; Gailus-Durner, V. ; Fuchs, H. ; Klopstock, T. ; Hrabé de Angelis, M. ; Jandeleit-Dahm, K. ; Shah, A.M. ; Weissmann, N. ; Schmidt, H.H., Wingler Kirstin, Stoll Guido, Weissmann Norbert, Schrewe Anja, Jandeleit-Dahm Karin, Meuth Sven G., Shah Ajay M., Herrmann Alexander M., Grund Henrike, Gailus-Durner Valérie, Becker Lore   +142 more
core   +1 more source

Smad3-Targeted Therapy Protects against Cisplatin-Induced AKI by Attenuating Programmed Cell Death and Inflammation via a NOX4-Dependent Mechanism

Kidney Diseases, 2021
Background: Transforming growth factor-β (TGF-β)/Smad signaling is the central mediator in renal fibrosis, yet its functional role in acute kidney injury (AKI) is not fully understood.
Qin Yang, Li Gao, Xiao-wei Hu, Jia-nan Wang, Yao Zhang, Yu-hang Dong, Hui Yao Lan, Xiao-ming Meng   +7 more
doaj   +1 more source

NOX4 is an early initiator of neuropathic pain [PDF]

Experimental Neurology, 2017
Treatment of neuropathic pain remains challenging as the etiology is heterogeneous and pathomechanisms are incompletely understood. One possible mechanism is oxidative stress due to unphysiological reactive oxygen species (ROS) formation. The only know dedicated enzymatic source of ROS are NADPH oxidases of which the type 4 isoform (NOX4) has been ...
Geis, Christian, Geuss, Eva, Sommer, Claudia, Schmidt, Harald H.H.W., Kleinschnitz, Christoph   +4 more
openaire   +3 more sources

NADPH Oxidase 1 and NADPH Oxidase 4 Have Opposite Prognostic Effects for Patients with Hepatocellular Carcinoma after Hepatectomy

Gut and Liver, 2016
Background/AimsNicotinamide adenine dinucleotide phosphate oxidase (NOX)-mediated reactive oxygen species contribute to various liver diseases, including hepatocellular carcinoma (HCC).
Sang Yun Ha, Yong-Han Paik, Jung Wook Yang, Min Ju Lee, Hyunsik Bae, Cheol-Keun Park   +5 more
doaj   +1 more source

The Role of NOX4 in Parkinson’s Disease with Dementia [PDF]

International Journal of Molecular Sciences, 2019
The neuropathology of Parkinson’s disease with dementia (PDD) has been reported to involve heterogeneous and various disease mechanisms. Alpha-synuclein (α-syn) and amyloid beta (Aβ) pathology are associated with the cognitive status of PDD, and NADPH oxidase (NOX) is known to affect a variety of cognitive functions.
Dong-Hee Choi, In-Ae Choi, Cheol Lee, Ji Yun, Jongmin Lee   +4 more
openaire   +2 more sources