Results 11 to 20 of about 85,856,906 (279)

NADPH oxidase 4 and its role in the cardiovascular system [PDF]

Vascular Biology, 2019
The heart relies on complex mechanisms that provide adequate myocardial oxygen supply in order to maintain its contractile function. At the cellular level, oxygen undergoes one electron reduction to superoxide through the action of different types of ...
Stephen P Gray, Ajay M Shah, Ioannis Smyrnias   +2 more
doaj   +5 more sources

Implication of type 4 NADPH oxidase (NOX4) in tauopathy

Redox Biology, 2022
Aggregates of the microtubule-associated protein tau are a common marker of neurodegenerative diseases collectively termed as tauopathies, such as Alzheimer's disease (AD) and frontotemporal dementia.
Enrique Luengo, Paula Trigo-Alonso, Cristina Fernández-Mendívil, Ángel Nuñez, Marta del Campo, César Porrero, Nuria García-Magro, Pilar Negredo, Sergio Senar, Cristina Sánchez-Ramos, Juan A. Bernal, Alberto Rábano, Jeroen Hoozemans, Ana I. Casas, Harald H.H.W. Schmidt, Manuela G. López   +15 more
doaj   +9 more sources

Decoding NADPH oxidase 4 expression in human tumors

Redox Biology, 2017
NADPH oxidase 4 (NOX4) is a redox active, membrane-associated protein that contributes to genomic instability, redox signaling, and radiation sensitivity in human cancers based on its capacity to generate H2O2 constitutively.
Jennifer L. Meitzler, Hala R. Makhlouf, Smitha Antony, Yongzhong Wu, Donna Butcher, Guojian Jiang, Agnes Juhasz, Jiamo Lu, Iris Dahan, Pidder Jansen-Dürr, Haymo Pircher, Ajay M. Shah, Krishnendu Roy, James H. Doroshow   +13 more
doaj   +4 more sources

NADPH Oxidase 4: Crucial for Endothelial Function under Hypoxia—Complementing Prostacyclin [PDF]

Antioxidants
Aim: The primary endothelial NADPH oxidase isoform 4 (NOX4) is notably induced during hypoxia, with emerging evidence suggesting its vasoprotective role through H2O2 production. Therefore, we aimed to elucidate NOX4′s significance in endothelial function
Heike Brendel, Jennifer Mittag, Anja Hofmann, Helene Hempel, Sindy Giebe, Patrick Diaba-Nuhoho, Steffen Wolk, Christian Reeps, Henning Morawietz, Coy Brunssen   +9 more
doaj   +2 more sources

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. [PDF]

PLoS Biology, 2010
Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of the patients.
Christoph Kleinschnitz, Henrike Grund, Kirstin Wingler, Melanie E Armitage, Emma Jones, Manish Mittal, David Barit, Tobias Schwarz, Christian Geis, Peter Kraft, Konstanze Barthel, Michael K Schuhmann, Alexander M Herrmann, Sven G Meuth, Guido Stoll, Sabine Meurer, Anja Schrewe, Lore Becker, Valérie Gailus-Durner, Helmut Fuchs, Thomas Klopstock, Martin Hrabé de Angelis, Karin Jandeleit-Dahm, Ajay M Shah, Norbert Weissmann, Harald H H W Schmidt   +25 more
doaj   +2 more sources

NADPH Oxidase 1 and NADPH Oxidase 4 Have Opposite Prognostic Effects for Patients with Hepatocellular Carcinoma after Hepatectomy

Gut and Liver, 2016
Background/AimsNicotinamide adenine dinucleotide phosphate oxidase (NOX)-mediated reactive oxygen species contribute to various liver diseases, including hepatocellular carcinoma (HCC).
Sang Yun Ha, Yong-Han Paik, Jung Wook Yang, Min Ju Lee, Hyunsik Bae, Cheol-Keun Park   +5 more
doaj   +4 more sources

Endothelial NADPH oxidase 4 protects against angiotensin II‐induced cardiac fibrosis and inflammation [PDF]

ESC Heart Failure, 2021
Aims Endothelial activation and inflammatory cell infiltration have important roles in the development of cardiac fibrosis induced by renin–angiotensin system activation.
Minshu Wang, Colin E. Murdoch, Alison C. Brewer, Aleksandar Ivetic, Paul Evans, Ajay M. Shah, Min Zhang   +6 more
doaj   +2 more sources

Identification of the NADPH Oxidase 4 Inhibiting Principle of Lycopus europaeus [PDF]

Molecules, 2018
NADPH oxidase 4 (Nox4) has recently been implicated as driving force in cellular senescence. Thus, there is growing interest to develop Nox4 inhibitors, which might be valuable agents for cosmeceutical applications.
Silvia Revoltella, Giorgia Baraldo, Birgit Waltenberger, Stefan Schwaiger, Philipp Kofler, Julia Moesslacher, Astrid Huber-Seidel, Konrad Pagitz, Roland Kohl, Pidder Jansen-Duerr, Hermann Stuppner   +10 more
doaj   +3 more sources

The role of NADPH Oxidase 4 in Iraqi Osteoporosis Patients

Al-SalamJournal for Medical Science
Background: Osteoporosis is a common condition that occurs in bone leading to the loss of bone mass. It is caused by increased osteoclast activity which is differentiated by low bone density measured by dual-energy X-ray absorptiometry (DEXA).Objective:
ola H Fadhil, Ekhlass M. Taha, Muzahem Mohialdeen Taha, Esraa Jaafar Saheb   +3 more
doaj   +2 more sources

NADPH oxidase 4 expression in the normal endometrium and in endometrial cancer [PDF]

Tumor Biology, 2019
The aim of this study was to explore the role of NOX4 in the biology of the normal endometrium and endometrial cancer. NOX4 plays a key role in other adenocarcinomas and has been implicated in the pathogenesis of diabetes and obesity, which are important
Christine Degasper, Andrea Brunner, Natalie Sampson, Irina Tsibulak, Verena Wieser, Hannah Welponer, Christian Marth, Heidi Fiegl, Alain Gustave Zeimet   +8 more
doaj   +3 more sources