Results 11 to 20 of about 39,145 (192)

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer. [PDF]

Phytother Res
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Shi LQ, Zhao JW, Zhu JY, Zhao C, Yang ZY, Pan LJ, Ma B, Chen ZY, Wang ZY, Li CJ, Liu SL, Mei JW, Dong P.   +12 more
europepmc   +2 more sources

Spatially Engineered Ternary Schottky/S-Scheme Heterojunctions for Artificial Photosynthesis. [PDF]

Angew Chem Int Ed Engl
A spatially integrated Nb2C/Nb2O5/ZnO heterostructure couples Schottky and S‐scheme interfaces to promote directional charge separation and photothermal‐assisted CO2 activation, enabling efficient photoreduction without molecular cocatalysts or sacrificial agents through synergistic interfacial engineering and carrier dynamic control.
Xu F, Mei W, Hu P, Zheng L, Zhang J, Cao H, García H, Yu J.   +7 more
europepmc   +3 more sources

Adrenomedullin Inhibits the Efficacy of Combined Immunotherapy and Targeted Therapy in Biliary Tract Cancer by Disrupting Endothelial Cell Functions. [PDF]

J Cell Mol Med
ABSTRACT The global incidence of biliary tract cancer (BTC) is on the rise, presenting a substantial healthcare challenge. The integration of immune checkpoint inhibitors (ICIs) with molecularly targeted therapies is emerging as a strategy to enhance immune responses.
Xuan Z, Hu H, Xu J, Ling X, Zhang L, Li W, Li J, Zhu C, Song Y, Zhang X, Rao J, Wang Y, Cheng F.   +12 more
europepmc   +2 more sources

Effect of BRCA1 R1325K mutation on proliferation and apoptosis of gallbladder cancer cells

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To investigate the effects of breast cancer susceptibility gene 1 (BRCA1) R1325K mutation [arginine (R) to lysine (K) mutation at amino acid 1325] on the proliferation and apoptosis of gallbladder cancer cell lines GBC-SD and NOZ.Methods·BRCA1 ...
YANG Jingxiao, JIA Ziyao, WU Wenguang, WU Xiangsong, ZHANG Fei, LI Huaifeng, ZHU Yidi, LI Maolan   +7 more
doaj   +1 more source

O Poder Psicoativo dos Alimentos: Análise de um Caso de Intoxicação com Noz-Moscada

Acta Médica Portuguesa, 2021
A ingestão de noz-moscada em doses elevadas provoca consequências médicas e psiquiátricas potencialmente graves e incapacitantes. Nenhum componente isolado da noz-moscada foi identificado como responsável por todos os sintomas observados durante a ...
Desidério Duarte, Marta Mendonça, Luís Ramos   +2 more
doaj   +1 more source

EGFR-targeted fluorescent imaging using the da Vinci® Firefly™ camera for gallbladder cancer

World Journal of Surgical Oncology, 2022
Background Fluorescent imaging may aid with the precise diagnosis and treatment of patients with gallbladder cancer. In this study, we sought to demonstrate whether the da Vinci® surgical system and Firefly™ camera could detect EGFR-targeted fluorescent ...
Jung Ha Choi, Chang Moo Kang, Jeong Youp Park   +2 more
doaj   +1 more source

The oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1

Journal of Translational Medicine, 2023
Background Gallbladder cancer (GBC) is the most prevalent and invasive biliary tract malignancy. As a GTPase-activating protein, Neurofibromin 1 (NF1) is a tumor suppressor that negatively regulates the RAS signaling pathway, and its abnormality leads to
Lingxiao Zhang, Lin Jiang, Ling Zeng, Zhaohui Jin, Xuanjia Dong, Yuhan Zhang, Litian Chen, Yijun Shu, Yingbin Liu, Ying Huang   +9 more
doaj   +1 more source

Super-Enhancer Reprograming Driven by SOX9 and TCF7L2 Represents Transcription-Targeted Therapeutic Vulnerability for Treating Gallbladder Cancer. [PDF]

Adv Sci (Weinh)
This study explores epigenetic mechanisms underlying oncogenesis of gallbladder cancer (GBC), revealing SOX9 and TCF7L2 can form a core regulatory circuitry (CRC) to drive oncogenic SE reprogramming and subsequent transcriptional activation of critical malignant genes. The SOX9/TCF7L2 double‐high GBCs exhibit worse prognosis and are susceptible to CDK7‐
Yan S, Liu Z, Wang T, Sui Y, Wu X, Shen J, Pu P, Yang Y, Wu S, Qiu S, Wang Z, Jiang X, Feng F, Li G, Liu F, Zhao C, Liu K, Feng J, Li M, Man K, Wang C, Tang Y, Liu Y.   +22 more
europepmc   +2 more sources

Establishment and characterization of the gemcitabine-resistant human gallbladder cancer cell line NOZ GemR [PDF]

Annals of Medicine and Surgery
Xu M, Xu S, Jiang B, Man Z.
exaly   +2 more sources

Forkhead box L1 is frequently downregulated in gallbladder cancer and inhibits cell growth through apoptosis induction by mitochondrial dysfunction. [PDF]

PLoS ONE, 2014
Forkhead box L1 (FOXL1), considered as a novel candidate tumor suppressor, suppresses proliferation and invasion in certain cancers. However, the regulation and function of FOXL1 in gallbladder cancer (GBC) remains unclear.FOXL1 expression at mRNA and ...
Yiyu Qin, Wei Gong, Mingdi Zhang, Jiandong Wang, Zhaohui Tang, Zhiwei Quan   +5 more
doaj   +1 more source