Results 51 to 60 of about 272,983 (311)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The Problem of Finding the Maximal Multiple Flow in the Divisible Network and its Special Cases

Моделирование и анализ информационных систем, 2015
In the article the problem of finding the maximal multiple flow in the network of any natural multiplicity k is studied. There are arcs of three types: ordinary arcs, multiple arcs and multi-arcs.
A. V. Smirnov
doaj   +1 more source

The complexity of deciding whether a graph admits an orientation with fixed weak diameter [PDF]

Discrete Mathematics & Theoretical Computer Science, 2016
An oriented graph $\overrightarrow{G}$ is said weak (resp. strong) if, for every pair $\{ u,v \}$ of vertices of $\overrightarrow{G}$, there are directed paths joining $u$ and $v$ in either direction (resp. both directions).
Julien Bensmail, Romaric Duvignau, Sergey Kirgizov   +2 more
doaj   +1 more source

NP-completeness results for edge modification problems [PDF]

, 2006
The aim of edge modification problems is to change the edge set of a given graph as little as possible in order to satisfy a certain property. Edge modification problems in graphs have a lot of applications in different areas, and many polynomial-time ...
Guillermo Durán, Burzyn, P., Durán Maggiolo, Guillermo, Pablo Burzyn, Burzyn, Pablo, Durán, G., Bonomo, Flavia, Durán, Guillermo, Bonomo, F., Flavia Bonomo   +9 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Extending Unification in $\mathcal{EL}$ to Disunification: The Case of Dismatching and Local Disunification [PDF]

Logical Methods in Computer Science, 2017
Unification in Description Logics has been introduced as a means to detect redundancies in ontologies. We try to extend the known decidability results for unification in the Description Logic $\mathcal{EL}$ to disunification since negative constraints ...
Franz Baader, Stefan Borgwardt, Barbara Morawska   +2 more
doaj   +1 more source

NP-completeness notions under strong hypotheses

, 2000
A variety of completeness notions for the complexity class NP are studied under strong hypotheses about the size of this class. These hypotheses are based on the concept of resource-bounded genericity developed by Ambos-Spies, Fleischhack and Huwig.
Bentzien, Levke
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

ANALYSIS AND IMPLEMENTATION OF A CRYPTOSYSTEM BASED ON NON-INJECTIVE KNAPSACKS

Безопасность информационных технологий
The paper explores the properties of non-injective linear forms and their application in knapsack cryptosystems. The primary objective of the study is to analyze the potential of using non-injective knapsacks as private keys to enhance the cryptographic ...
Maria Sabina A. Volkov
doaj   +1 more source

Splitting Number is NP-Complete

Discrete Applied Mathematics, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Luérbio Faria, Celina M. H. de Figueiredo, Candido Ferreira Xavier de Mendonça Neto   +2 more
openaire   +2 more sources