Results 61 to 70 of about 272,983 (311)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
On the Complexity of the 3-Kernel Problem in Some Classes of Digraphs
Discussiones Mathematicae Graph Theory, 2014 Let D be a digraph with the vertex set V (D) and the arc set A(D). A subset N of V (D) is k-independent if for every pair of vertices u, v ∈ N, we have d(u, v), d(v, u) ≥ k; it is l-absorbent if for every u ∈ V (D) − N there exists v ∈ N such that d(u, v)
Hell Pavol, Hernández-Cruz César
doaj +1 more source
Complexity of Timeline-Based Planning over Dense Temporal Domains: Exploring the Middle Ground [PDF]
Electronic Proceedings in Theoretical Computer Science, 2018 In this paper, we address complexity issues for timeline-based planning over dense temporal domains. The planning problem is modeled by means of a set of independent, but interacting, components, each one represented by a number of state variables, whose
Laura Bozzelli +3 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Computational Complexity of Some Problems on Generalized Cellular Automations
Безопасность информационных технологий, 2012 We prove that the preimage problem of a generalized cellular automation is NP-hard. The results of this work are important for supporting the security of the ciphers based on the cellular automations.
P. G. Klyucharev
doaj
The complexity of class TAUTOLOGY-NP
, 2018 P versus NP is considered as one of the most important open problems in computer science. This consists in knowing the answer of the following question: Is P equal to NP?
Frank Vega (4690180)
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
CoRRThis study examines the computational complexity of the decision problem modeled on the smartphone game Bus Out. The objective of the game is to load all the passengers in a queue onto appropriate buses using a limited number of bus parking spots by selecting and dispatching the buses on a map.
Takehiro Ishibashi +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source