Results 61 to 70 of about 369,293 (294)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Mathematics, 2022 In this work, we investigate the variant of the Internet Shopping Optimization Problem (ISHOP) that considers different item units. This variant is more challenging than the original problem. The original ISHOP is already known as a combinatorial NP-hard
Fernando Ornelas +9 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Computational Complexity of Some Problems on Generalized Cellular Automations
Безопасность информационных технологий, 2012 We prove that the preimage problem of a generalized cellular automation is NP-hard. The results of this work are important for supporting the security of the ciphers based on the cellular automations.
P. G. Klyucharev
doaj
ANALYSIS AND IMPLEMENTATION OF A CRYPTOSYSTEM BASED ON NON-INJECTIVE KNAPSACKS
Безопасность информационных технологийThe paper explores the properties of non-injective linear forms and their application in knapsack cryptosystems. The primary objective of the study is to analyze the potential of using non-injective knapsacks as private keys to enhance the cryptographic ...
Maria Sabina A. Volkov
doaj +1 more source
The Problem of Finding the Maximal Multiple Flow in the Divisible Network and its Special Cases
Моделирование и анализ информационных систем, 2015 In the article the problem of finding the maximal multiple flow in the network of any natural multiplicity k is studied. There are arcs of three types: ordinary arcs, multiple arcs and multi-arcs.
A. V. Smirnov
doaj +1 more source
CoRR, 2014 We prove that completing an untimed, unbounded track in TrackMania Nations Forever is NP-complete by using a reduction from 3-SAT and showing that a solution can be checked in polynomial time.
openaire +2 more sources
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
On the Complexity of the 3-Kernel Problem in Some Classes of Digraphs
Discussiones Mathematicae Graph Theory, 2014 Let D be a digraph with the vertex set V (D) and the arc set A(D). A subset N of V (D) is k-independent if for every pair of vertices u, v ∈ N, we have d(u, v), d(v, u) ≥ k; it is l-absorbent if for every u ∈ V (D) − N there exists v ∈ N such that d(u, v)
Hell Pavol, Hernández-Cruz César
doaj +1 more source
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source