Results 101 to 110 of about 219,041 (325)
Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD
Advanced Science, EarlyView.Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du +6 more
wiley +1 more source
DIGITAL SUBSTATION COMPONENT SYSTEM "SMART GRID"
Electrical engineering & Electromechanics, 2014 New production technologies of modern control systems have moved from the stage of research and experimentation into the stage of practical use. Modern communication standards for the exchange of information are developed and introduced. Digital devices,
V.I. Vasilchenko +4 more
doaj
Advanced Science, EarlyView.CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang +17 more
wiley +1 more source
Novel Mutations in NPC1 are Associated with Pelizaeus-Merzbacher-Like Disease: A Case Report
International Journal of General Medicine, 2021 Hongling Fu,1,2 Qiu Wang,2,3 Hanmin Liu1,2 1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Key Laboratory of Birth Defect and Related Diseases of Women and ...
Fu H, Wang Q, Liu H
doaj
cDC1 Subtype‐Specific In Vivo Targeting of Liposomes
Advanced Science, EarlyView.Dendritic cells, particularly the cDC1 subtype, offer a promising target for drug delivery via liposomes due to their pivotal role in immune regulation, allowing for amplified therapeutic responses. Herein, we show an integration of physicochemical characterization and cell experiments to achieve effective in vivo cDC1 targeting through anti‐CLEC9A ...
Maximilian Schaaf +11 more
wiley +1 more source
THE MAIN FACTORS AFFECTING THE LEVEL AND FORM OF WATER-OIL CONTACT
Известия высших учебных заведений: Нефть и газ, 2015 The paper discusses the main causes of inclined oil-water contacts occurrence in the deposits Strezhevskoye and Krapivinskoe of the West Siberian plate, confined to the deposits of Vasyugan formation.
A. V. Podnebesnykh, V. P. Ovchinnikov
doaj +1 more source
Monotonic Properties of the Least Squares Mean
, 2010 We settle an open problem of several years standing by showing that the least-squares mean for positive definite matrices is monotone for the usual (Loewner) order.
Lawson, Jimmie, Lim, Yongdo
core +1 more source
Journal of Biomedical Sciences, 2018 Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer, with diverse molecular characteristics and clinical outcomes. This study aims to dissect the molecular heterogeneity of NPC, followed by the construction of a microRNA (miRNA ...
Lan Zhao, A. H. Fong, Na Liu, W. Cho
semanticscholar +1 more source
Advanced Science, EarlyView.This study presents S‐coordinated Cu single‐atom nanozymes (Cu/CNS) fabricated via mild photocatalytic self‐assembly strategy. The nanozyme exhibits exceptional multi‐enzyme activity and near‐perfect antimicrobial efficacy. Incorporated into chitosan‐gelatin film, it enables pH‐responsive, broad‐spectrum fruit preservation, more than doubling the shelf‐
Chuanlong Men +7 more
wiley +1 more source
Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source