Results 111 to 120 of about 114,500 (312)

Visualisation of in vivo protein synthesis during mycobacterial infection through [68Ga]Ga-DOTA-puromycin µPET/MRI

open access: yesScientific Reports
Radiolabelled puromycin analogues will allow the quantification of protein synthesis through nuclear medicine-based imaging. A particularly useful application could be the non-invasive longitudinal visualisation of mycobacterial activity through direct ...
Sebastian Eigner   +5 more
doaj   +1 more source

The Soliton and the Action Potential – Primary Elements Underlying Sentience

open access: yesFrontiers in Physiology, 2018
At present the neurological basis of sentience is poorly understood and this problem is exacerbated by only a partial knowledge of how one of the primary elements of sentience, the action potential, actually works.
Andrew S. Johnson   +4 more
doaj   +1 more source

The NPC-Transporter, A Ghost in the Machine [PDF]

open access: yesStructure, 2010
Yeast FG nucleoporins are intrinsically disordered proteins that contain cohesive molten globular regions and repulsive extended-coil regions. When placed along the central axis of the NPC, FG nups may self-assemble to create a novel transport channel that provides a series of docking sites for karyopherin-cargo complexes (Yamada et al., 2010).
openaire   +2 more sources

Hysteretic multilevel NPC converter control for a Switch Mode Assisted Linear Amplifier [PDF]

open access: yes, 2006
A Switch-Mode Assisted Linear Amplifier (SMALA) combines the high quality of a linear amplifier required for audio applications with the high efficiency of a switch-mode amplifier.
Walker, Geoffrey R.
core  

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

open access: yesAdvanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen   +9 more
wiley   +1 more source

ASMR NPC

open access: yesMedia Theory
This paper considers the stimulation afforded by ASMR NPC (autonomous sensory meridian response non-playable character) streams through the conceptual framework of ‘possession.’ First, it looks at several examples of popular ASMR NPC streams, noting the distinct manner in which ASMR NPC streamers become, like the non-player characters of role-playing ...
openaire   +1 more source

Recent advances in the treatment of nasopharyngeal carcinoma.

open access: yes, 2009
The outcome of nasopharyngeal carcinoma (NPC) treatment has greatly improved as advances in imaging techniques increase the accuracy of tumor mapping. Radiotherapy remains a common treatment for early disease, while concurrent chemoradiotherapy is being ...
CHANG, JOSEPH TUNG-CHIEH;KO, JENQ-YUH;HONG, RUEY-LONG   +1 more
core  

Carrier‐Free Stimulus‐Responsive Theranostic Nanoprodrug Enabling GSH‐Consumption‐Promoted Chemo‐Photodynamic Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Leveraging the critical role of glutathione (GSH) in mediating drug resistance and scavenging reactive oxygen species (ROS) in cancer cells, a carrier‐free GSH‐consuming theranostic nanoprodrug, consisting of a BODIPY photosensitizer and the chemotherapeutic drug paclitaxel linked through a GSH‐consuming drug linker, is developed to deeply explore the ...
Hansheng Huang, Binglin Sui
wiley   +1 more source

Management of NPC

open access: yesIranian Journal of Child Neurology, 2015
How to Cite This Article: Jafari N. Management of NPC. Iran J Child Neurol. 2015 Autumn;9:4(Suppl.1): 24.   Pls see pdf.  
openaire   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

open access: yesAdvanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao   +20 more
wiley   +1 more source

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