Digital Transformation of Medicines Regulation in Africa—Perspectives from a Stakeholder Convening
Clinical Pharmacology &Therapeutics, EarlyView.Regulatory authorities worldwide are developing strategies to integrate artificial intelligence (AI) into the lifecycle of health products, technologies, and medicines. While regulators share goals of improving efficiency, strengthening decision‐making, and protecting public health, their approaches differ according to institutional structures ...
Christelna Reyneke +12 more
wiley +1 more source
Combined multi-omics profiling and machine learning analysis reveals that Bregs and RPS2 promote bone metastasis in nasopharyngeal carcinoma. [PDF]
Transl Cancer ResYang K +10 more
europepmc +1 more source
The Governance Gap: Democratizing Drug Development Through Decision Architecture
Clinical Pharmacology &Therapeutics, EarlyView.Drug development is most exposed to governance failure where it can least afford it, in global health. The field has more predictive power than at any point in its history and roughly the same failure rate it had a decade ago. We argue that this paradox persists because the field has invested heavily in prediction science while neglecting decision ...
Craig R. Rayner +16 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Anakinra, an interleukin‐1 receptor antagonist, shows promise for reducing inflammatory complications of premature birth. However, the pharmacokinetics (PK) of anakinra in neonates has not been characterized, limiting evidence‐based dosing. This study aimed to develop a population PK model for anakinra to guide dosing in preterm neonates.
Jia Li +27 more
wiley +1 more source
lncRNA JPX promotes radioresistance in nasopharyngeal carcinoma via the miR-1301-3p/PIK3R2-mediated autophagy pathway. [PDF]
Transl Cancer ResOuyang S, Lv J, Wang Y, Ying Y, Jin Q.
europepmc +1 more source
Summary of the pilot study for NPC:Chemoradiotherapy for NPC(NPC-1)
Summary of the pilot study for NPC:Chemoradiotherapy for NPC(NPC-1)FNCA Seminar on Radiation Oncology ...
openaire +1 more source
A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)
Developmental Dynamics, EarlyView.Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble +2 more
wiley +1 more source
Epstein-Barr virus based biomarkers and targeted therapies in nasopharyngeal carcinoma: a narrative review. [PDF]
Lancet Reg Health West PacFeng SY, Shu RJ, Liu N, Ma J.
europepmc +1 more source
Heterogeneous Single/Dual‐Atom Electrocatalysts in Lithium–Sulfur Batteries
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.This review summarizes recent advances in single‐atom and dual‐atom electrocatalysts for high‐performance lithium–sulfur batteries. The text systematically covers the classification of catalysts by active metal centers, key synthesis methods, in situ characterization for mechanistic insights, and electrocatalytic mechanisms.
Wenbin Li +3 more
wiley +1 more source
Nucleoporins in Cancer: Functional Roles and Therapeutic Opportunities. [PDF]
Cancer DiscovKirthika P +4 more
europepmc +1 more source