Results 201 to 210 of about 114,500 (312)

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

Bidirectional optoelectronic switching in protein by photoinduced phase transition. [PDF]

Sci Adv
Zhou G, Wang X, Xie X, Zhou Y, Sun B, Chai Y.   +5 more
europepmc   +1 more source

Hybrid Simulation–Machine Learning Surrogates for Coordinate‐Based Solar and Wind Energy Yield Assessment in Iraq: A Streamlit Decision‐Support Tool

Energy Science &Engineering, EarlyView.
This study integrates climatic simulations with machine learning to predict solar and wind energy across Iraq. Results show Random Forest excels for solar (R2 = 0.98) and neural networks for wind (R2 = 0.97), enabling a practical web tool for renewable energy planning. ABSTRACT Driven by the global shift away from fossil fuels, solar and wind resources
Bassam Musheer Kareem, Abdolsalam Ebrahimpour, Jafar Ghafouri, Roghayyeh Motallebzadeh   +3 more
wiley   +1 more source

Integrative microbiome and functional profiling identify <i>Streptococcus anginosus</i> as a pro-tumorigenic driver in nasopharyngeal carcinoma. [PDF]

mSystems
Zhu Y, Zhou L, Zhang C, Li Z, Ding T, Su Y.   +5 more
europepmc   +1 more source

Techno‐Economic and Quasi‐Dynamic Load Flow Analysis of a Hybrid Renewable Microgrid for Coastal Industrial Loads

Energy Science &Engineering, EarlyView.
A hybrid PV–wind grid‐connected microgrid for Mongla Port is optimized using HOMER Pro and validated via DIgSILENT quasi‐dynamic load flow. The system achieves a low cost of energy (0.0341 USD/kWh), 70.9% renewable penetration, improved voltage stability, and significant emission reduction, demonstrating a reliable and cost‐effective solution for ...
Md. Behesty Hasan Sagor, Md Abdus Samad Kamal, Md. Feroz Ali, Md. Mahedi Hasan, Fahad Saleh Al‐Ismail, Md Shafiul Alam, Mohammad Ali   +6 more
wiley   +1 more source

Evaluating the Prognostic Relevance of Pre-Treatment Epstein-Barr Virus Levels in Non-Endemic Pediatric Nasopharyngeal Carcinoma. [PDF]

Cancers (Basel)
Farrag A, Yang Y, Piao J, Younis L, Wagner HJ, Christiansen H, Römer T, Poore A, Szot C, Thibeau N, Yom SS, Pinsky BA, Le QT, Kamihara J, Ting DT, Laetsch TW, Chen KS, Rodriguez-Galindo C, Hayden RT, Kontny U, Gartrell RD.   +20 more
europepmc   +1 more source

Effect of exercise‐related nasopharyngeal disorders on upper airway function in racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background Exercise‐related upper respiratory tract (URT) disorders are frequently diagnosed in racehorses. Treatment recommendations are routinely based on subjective assessment of clinical evaluation and exercising endoscopy findings. Objectives To objectively investigate how palatal instability (PI), intermittent dorsal displacement of the ...
Hanna Vermedal, Ingunn Risnes Hellings, Zoe L. Fretheim‐Kelly, Constanze Fintl, Eric Strand   +4 more
wiley   +1 more source

Emerging Biomarkers and Biotherapies for EBV-Associated Cancers. [PDF]

Viruses
White MC, Damania B.
europepmc   +1 more source

Randomized Phase II Trial of Consolidation Pembrolizumab After Definitive Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma: KCSG HN19‐09, CONPELAN Study

Head &Neck, EarlyView.
ABSTRACT Background The benefit of consolidation programmed cell death protein 1 (PD‐1) blockade after chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma (NPC) remains unclear. Methods Patients with stages II–IVB NPC were randomized (2:1) to pembrolizumab 200 mg or placebo every 3 weeks for up to 17 cycles after chemoradiotherapy ...
Sang Hoon Chun, Seyoung Seo, Jang Ho Cho, Keon‐Uk Park, Sang‐Cheol Lee, Yong Won Choi, Tak Yun, Seong Hoon Shin, Sung‐Bae Kim, Seungeun Lee, Chang Ho Ahn, Bhumsuk Keam   +11 more
wiley   +1 more source

TPPP3 Overexpression Suppresses Nasopharyngeal Carcinoma Progression and Promotes Immune Microenvironment Remodeling Through HSPA8 Association. [PDF]

Cancers (Basel)
Li S, Liao J, Yang J, Han Y, Lei Z, Yang Z.   +5 more
europepmc   +1 more source