Results 41 to 50 of about 114,500 (312)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

The NPC, in detail [PDF]

The Journal of Cell Biology, 2007
The nuclear pore complex (NPC) is a huge cylindrical assembly that transports material to and from the nucleus. In a biological tour de force, researchers have determined the positions of all 456 proteins of the NPC, providing structural insights of unprecedented detail.
openaire   +1 more source

CD4 T cell accumulation is reduced in EB-NPC-transplanted mice.

, 2016
(A) Representative FACS plots demonstrating the frequency of CD4+ and CD8+ cells in the spinal cords of EB-NPC, human fibroblast, and HBSS-injected mice at day 21 pt. (B) Quantification of the frequency of CD4 and CD8 T cells.
Craig M. Walsh (2839346), Ronald Coleman (695730), Angel Zavala (2839337), Warren C. Plaisted (2839343), Ha Tran (375720), Thomas E. Lane (117519), Edna Hingco (2839340), Jeanne F. Loring (201461)   +7 more
core   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Enabling social approaches for contextualised learning at primary schools

Global Social Challenges Journal
Through a project undertaken under a programme funded by United Kingdom Research and Innovation (UKRI) called Transforming Education for Sustainable Futures (TESF), alternative learning approaches associated with the introduction of a form of vertical ...
Brigid Letty, Jon McCosh, Lunga Dlungwana, Mzokhona Mndali   +3 more
doaj   +1 more source

In vitro transdifferentiation of human adipose tissue-derived stem cells to neural lineage cells - a stage-specific incidence

Adipocyte, 2019
The present Study investigated the intrinsic ability of adipose tissue-derived stem cells (ADSCs) and their neural transdifferentiation in a stage-specific manner.
Subathra Radhakrishnan, Omana Anna Trentz, Mettu Srinivas Reddy, Mohamed Rela, Mahesh Kandasamy, Shanmugaapriya Sellathamby   +5 more
doaj   +1 more source

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

Advanced Materials, EarlyView.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena, Lucia Castillo Ransanz, Ruben H. Guis, Giulia Bergamaschi, Nanne J. Paauw, Urs Staufer, Vivi M. Heine, Angelo Accardo   +7 more
wiley   +1 more source

The Power Analysis of Semiconductor Devices in Multi-Phase Traction Inverter Topologies Applicable in the Automotive Industry

Communications
The article deals with the power analysis of semiconductor devices nowadays commonly used in perspective traction inverter topologies suitable for automotive industry applications.
Jakub Šimčák, Michal Frivaldský, Patrik Resutík   +2 more
doaj   +1 more source

MemoryRepository for AI NPC

IEEE Access
Since the release of ChatGPT, large language models (LLMs) have played a huge role in various industries. In the field of games, we have used LLMs to act as intelligent AI NPC, which makes NPCs more intelligent. However, there is still an obvious obstacle -the LLMs lacks long-term memory and human-like memory mechanism.
Shijie Zheng, Keith He, Le Yang, Jie Xiong   +3 more
openaire   +3 more sources