Results 191 to 200 of about 13,156 (213)

Reaction of Mes NPC1 with Triphenylcarbenium Tetrafluoroborate

Phosphorus, Sulfur, and Silicon and the Related Elements, 1994
Abstract Reaction of Mes NPC1 with triphenylcarbenium salts (BF4 or PF6) produces a difluorophosphine and not the expected iminophosphenium cation. This compound then undergoes an Arbusov-type rearrangement to generate a difluoro-iminophosphorane.
Neil Burford, Jason A. C. Clyburne, Pradip K. Bakshi, T. Stanley Cameron   +3 more
openaire   +1 more source

NPC1-deficient neurons are selectively vulnerable for statin treatment

Neuropharmacology, 2019
Niemann Pick C (NPC) is a fatal hereditary neurovisceral disorder associated with a progressive loss of neurons of unknown mechanism. The disease is caused by mutation in either of two genes, termed npc1 and npc2, accounting for ∼95% and ∼5% of patients, respectively. Recent data suggest a cell-autonomous cause for neuronal cell death.
Volker, Meske, Frank, Albert, Sandra, Gerstenberg, Knut, Kallwellis, Thomas G, Ohm   +4 more
openaire   +2 more sources

NPC1‐mediated cholesterol export from lysosomes

The FASEB Journal, 2017
Endocytosed, LDL‐derived cholesterol is exported from the interior of lysosomes by a process that requires the action of NPC1 and NPC2 proteins. We have recently shown that LAMP1 and LAMP2 proteins interact with NPC1 and NPC2 and also bind cholesterol (1).
openaire   +1 more source

Proteins that bind and move lipids: MsbA and NPC1

Critical Reviews in Biochemistry and Molecular Biology, 2011
Membrane proteins that bind and transport lipids face special challenges. Since lipids typically have low water solubility, both accessibility of the substrate to the protein and delivery to the desired destination are problematical. The amphipathic nature of membrane lipids, and their relatively large molecular size, also means that these proteins ...
Gavin, King, Frances J, Sharom
openaire   +2 more sources

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

Developmental Cell, 2021
Hijai R Shin, Chun-Yan Lim, Rushika M Perera   +2 more
exaly  

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

Nature Communications, 2021
Alessio Vittorio Colombo, Stephan A Müller, Laura Sebastian Monasor   +2 more
exaly  

Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2

Cell, 2020
Hongwu Qian, Ximing Du, Xia Yao
exaly  

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

Cell, 2009
Johann Deisenhofer, Joseph L Goldstein, Rodney E Infante   +2 more
exaly  

Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes

Cell Metabolism, 2010
Rodney E Infante, Joseph L Goldstein, Michael S Brown   +2 more
exaly  

The Extending Spectrum of NPC1-Related Human Disorders: From Niemann–Pick C1 Disease to Obesity

Endocrine Reviews, 2018
Amel Lamri, Marie Pigeyre, William S Garver   +2 more
exaly