Results 101 to 110 of about 119,560 (316)
From NPT to TPNW: From Non-proliferation to Prohibition of Nuclear Weapons [PDF]
, 2023 Barbara Gallo
openalex +1 more source
Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli
Advanced Science, EarlyView.An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng +6 more
wiley +1 more source
Advanced Science, EarlyView.Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo +7 more
wiley +1 more source
Advanced Science, EarlyView.Chromosome segregation in Streptococcus pneumoniae depends on RocS, a bitopic protein whose membrane‐anchoring mechanisms were unclear. Using NMR and AFM, this study reveals that the widely conserved RocS anchor binds to membranes via a conserved kink‐helix motif which inserts into lipid nanodomains.
Ana Álvarez‐Mena +11 more
wiley +1 more source
Nuclear Non-proliferation Treaty (NPT) [PDF]
, 2011 The Treaty on the Non-Proliferation of Nuclear Weapons opened for signatories on 1 July 1968. It came into force on 5 March 1970. A review meeting takes place every five years. The initial treaty was limited to a 25-year term but it was extended indefinitely in 1995.
openaire +4 more sources
Structural and Mechanical Dynamics of Polymer Membranes Across Multilength Scales
Advanced Science, EarlyView.Distinct surface‐to‐bulk mechanical contrasts in polymer membranes were unveiled, highlighting the need to probe both regions to fully capture their functional behavior. By integrating in situ SAXS–WAXS with AFM‐based nanomechanics, nanodomain‐level heterogeneity and real‐time structural transformations induced by thermal and mechanical stimuli were ...
Rifan Hardian +6 more
wiley +1 more source
BMC Ophthalmology, 2017 Background The aim of this work is to evaluate efficacy and tolerability of preservative containing 0.0015% tafluprost and preservative-free 0.0015% tafluprost using a prospective crossover study.
Wonseok Lee +4 more
doaj +1 more source
Stewardship of Test-Free Nuclear Arsenals [PDF]
, 2006 Maintaining nuclear arms in the current policy environment that frowns upon weapons testing coexists with a set of unresolved and disquieting issues regarding the disposition of test-free arsenals.
Ivan Safranchuk, Vladimir Belous
core
Advanced Science, EarlyView.This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen +10 more
wiley +1 more source