Results 101 to 110 of about 117,023 (322)
Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance
Advanced Science, EarlyView.Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao +5 more
wiley +1 more source
Crystal Polymorph Search in the NPT Ensemble via a Deposition/Sublimation Alchemical Path [PDF]
, 2023 Aaron Nessler +7 more
openalex +1 more source
Advanced Science, EarlyView.Quasi‐solid‐state calcium‐ion batteries (QSSCIBs) employing redox‐active covalent organic frameworks (COFs) based electrolytes are developed. The COFs’ crystalline porous structures, featuring aligned carbonyl groups, enabled high Ca2⁺ conductivity, supported by molecular dynamics simulations of the ion transport mechanism.
Zhuoyu Yin +7 more
wiley +1 more source
Advanced Science, EarlyView.Cysteine‐tagged silk‐elastin‐like proteins, a family of tri‐block chimeric proteins that consist of a photothermal agent binding motif, silk motif, and elastin motif is developed to form a responsive in situ hydrogel for late‐stage and metastatic triple‐negative breast cancer.
Xinchen Shen +11 more
wiley +1 more source
Advanced Science, EarlyView.A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li +8 more
wiley +1 more source
Advanced Science, EarlyView.FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu +8 more
wiley +1 more source
Advanced Science, EarlyView.Puerarin targets mitochondrial MIC19 in tumor‐infiltrating Tregs, impairing their immunosuppressive function and enhancing antitumor immunity. This study uncovers the metabolic dependency of tumor‐infiltrating Tregs and highlights a potential metabolic‐targeted immunotherapeutic strategy for liver cancer. Abstract Regulatory T cells (Tregs) are pivotal
Yu Li +10 more
wiley +1 more source