Results 111 to 120 of about 52,027 (252)
Advanced Science, EarlyView.Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu +6 more
wiley +1 more source
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Hepatology, EarlyView., 2022 Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann +25 more
wiley +1 more source
Statistical Analysis of the Negative–Positive Transformation in Image Encryption
MathematicsThe negative–positive transformation (NPT) is a widely employed technique for encrypting images on pixel blocks, commonly integrated into cryptosystems compatible with compression algorithms.
Manuel Alejandro Cardona-López +3 more
doaj +1 more source
, 2020 In innovative drug markets the widespread practice across the EU of country-specific confidential agreements reached between national payers and innovative pharmaceutical manufacturers continues to be a highly disputed basis for pharmaceutical health ...
Swoboda, Torben +2 more
core
Advanced Science, EarlyView.This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao +12 more
wiley +1 more source
The role of Mozart's music in sudden unexpected death in epilepsy: A new open window of a dark room
, 2008 Universidade Federal de São Paulo, Escola Paulista Med, Lab Neurol Expt, São Paulo, BrazilUNIFESP EPM, Dept Fisiol, São Paulo, BrazilUniv Mogi Cruzes NPT UMC, Nucleo Pesquisas Technol, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista ...
Scorza, Fulvio A. [UNIFESP] +3 more
core +1 more source
Advanced Science, EarlyView.Flux‐protection engineering stabilizes an oxidation‐prone L‐DOPA node in engineered E. coli by combining acid‐adapted chassis evolution, respiratory‐chain modulation, enzyme‐level flux matching, and pH–DO control. Carbon is redirected from oxidative browning to productive biosynthesis, enabling 1075.2 mg/L curcumin and demonstrating transferability to ...
Jianbin Chen +10 more
wiley +1 more source
Multiparameter Collaborative Optimization and Analysis of the Non-Penetrating Tunnel Thruster
Journal of Marine Science and EngineeringA brand new non-penetrating tunnel thruster (short for NPT thruster) is proposed in this paper. The tunnel structural parameters of the thruster are optimized, and the performance and optimization effect are verified by experiments. First, the design and
Jinyu Guo +5 more
doaj +1 more source
Advanced Science, EarlyView.A novel strategy features gradient composition and stacking fault energy‐tuned (CoCrMn)100‐2xFexNix fabricated via in situ alloying additive manufacturing. This design circumvents cryogenic discontinuous plastic flow and hydrogen embrittlement of metallic materials under quasi‐static loading and hydrogen‐rich environment relevant to lunar polar ...
Renhao Wu +11 more
wiley +1 more source
Advanced Science, EarlyView.Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang +11 more
wiley +1 more source