Results 101 to 110 of about 52,027 (252)
Advanced Science, EarlyView.A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang +9 more
wiley +1 more source
, 2019 Der Atomwaffensperrvertrag, auch Nuklearer Nichtverbreitungsvertrag (NVV) genannt, wird als Eckpfeiler des globalen Nichtverbreitungsregimes gesehen. Obwohl der NVV in erster Linie ein völkerrechtlicher Vertragist, verkörpert der NVV jedoch eine wichtige
Koller Pope, Catherine
core
The 2005 NPT Review Conference: Mission Impossible?
, 2005 The 2005 Review Conference of the Treaty on the Non-Proliferation of Nuclear Weapons (NPT) failed to produce any agreed action plan for addressing nuclear disarmament or proliferation.
Nielsen, Jenny, Simpson, John
core +1 more source
Advanced Science, EarlyView.A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv +16 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou +9 more
wiley +1 more source
Advanced Science, EarlyView.The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang +7 more
wiley +1 more source
Advanced Science, EarlyView.A thermochemically engineered core–shell Si architecture is developed through the controlled evolution of a SWCNT‐coated Mg2Si precursor. The process simultaneously generates a nanoporous Si shell for strain accommodation and Li+ transport, a chemically anchored SiC interfacial layer for robust mechanical and electrical coupling, and a Mg‐containing Si
Dong Gyun Hong +11 more
wiley +1 more source
Společný postoj Evropské unie k NPT od roku 2015
, 2023 Tato práce se zabývá společným postojem EU k odzbrojení v období od roku 2015, kdy se konala devátá hodnotící konference smluvních stran Smlouvy o nešíření jaderných zbraní (NPT), do roku 2022, kdy se uskutečnila desátá hodnotící konference NPT ...
Csúzová, Kristína
core
Atomistic Kinetics of Dislocation‐Mediated Grain Growth in Monolayer MoS2
Advanced Science, EarlyView.Atomic‐resolution in‐situ heating microscopy directly visualizes dislocation‐mediated grain boundary migration and grain growth in monolayer MoS2. Mobile grain boundaries migrate through collective motion of Mo 5|7 dislocations, whereas S 5|7 defects remain largely immobile.
Chang‐Won Choi +11 more
wiley +1 more source
Advanced Science, EarlyView.AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan +13 more
wiley +1 more source