Results 111 to 120 of about 117,023 (322)
A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme
Advanced Science, EarlyView.The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun +12 more
wiley +1 more source
Advanced Science, EarlyView.The reaction properties of both electrodes in aqueous Zn‐S batteries is regulated by a tetramethylurea electrolyte additive. It preferentially adsorbs on the sulfur surface and coordinates to Zn2+, thereby altering their reaction process. The energy barrier is reduced and nucleation is promoted, which accelerates reaction kinetics.
Sibo Wang +7 more
wiley +1 more source
A Note on Resistance of NPT to Mixture of Separable States [PDF]
, 2013 Bobo Hua +7 more
openalex +1 more source
Advanced Science, EarlyView.This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong +15 more
wiley +1 more source
Advanced Science, EarlyView.In the aqueous AlCl3 electrolyte of aluminum‐metal batteries, the introduction of LaCl3 adjusts the solvation structure of Al3+ and enhances its diffusion level. The oxide precipitate formed by La3+ covers the aluminum metal anode and effectively alleviates corrosion reactions, thereby improving the cycling stability of the battery.
Yanshen Gao +12 more
wiley +1 more source
Wave‐Partition‐Governed Dual‐Site Spallation in Single Crystals
Advanced Science, EarlyView.Crystalline anisotropy shapes shock‐wave propagation and the resulting damage evolution in single crystals. Large‐scale molecular dynamics and damage modeling uncover a dual‐spallation mechanism driven by anisotropic elasticplastic wave separation, which mitigates damage accumulation.
Youlin Zhu +6 more
wiley +1 more source
Statistical Analysis of the Negative–Positive Transformation in Image Encryption
MathematicsThe negative–positive transformation (NPT) is a widely employed technique for encrypting images on pixel blocks, commonly integrated into cryptosystems compatible with compression algorithms.
Manuel Alejandro Cardona-López +3 more
doaj +1 more source
Advanced Science, EarlyView.Indole‐3‐acetic acid (IAA) acting as one of the aryl hydrocarbon receptor (AHR) endogenous ligands is identified to be derived from Lactobacillus salivarius via its catalytic enzyme (ALDH) rather than host cells. Lactobacillus salivarius and IAA supplementation effectively mitigate intestinal aging by facilitating AHR‐poly (ADP‐ribose) polymerase 1 ...
Zheng Cao +13 more
wiley +1 more source
Multiparameter Collaborative Optimization and Analysis of the Non-Penetrating Tunnel Thruster
Journal of Marine Science and EngineeringA brand new non-penetrating tunnel thruster (short for NPT thruster) is proposed in this paper. The tunnel structural parameters of the thruster are optimized, and the performance and optimization effect are verified by experiments. First, the design and
Jinyu Guo +5 more
doaj +1 more source