Results 201 to 210 of about 39,133 (289)

In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini, Simona Saporiti, Crescenzo Coppa, Mara Rossi, Fabio Centola, Alessandro Arcovito   +5 more
wiley   +1 more source

PhotoChem Reference Chemical Database for the Development of New Alternative Photosafety Test Methods. [PDF]

Toxics
Lee GY, Hwang JH, Hong JH, Bae S, Lim KM.   +4 more
europepmc   +1 more source

The role of the NPT in preventing further proliferation of nuclear weapons

Iryna Les
openalex   +2 more sources

Human Citrate Synthase Post‐Translational Modification Mimics and Molecular Dynamic Simulations Demonstrate Attenuation of Acetyl‐CoA/CoA Binding

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human citrate synthase (hCS) is a mitochondrial enzyme that catalyzes the aldol condensation of acetyl coenzyme A (AcCoA) to oxaloacetate to form citrate in the TCA cycle. CS activity is important for aerobic exercise performance and basic metabolic function as a housekeeping enzyme.
Noah Shackelford, Zach Zavodny, Nathan Fancher, Michael A. Moxley   +3 more
wiley   +1 more source

Translational framework for implementation evaluation and research: implementation strategies derived from normalization process theory. [PDF]

Implement Sci
May CR, Hillis A, Albers B, Desveaux L, Gilbert A, Girling M, Girling M, Kislov R, MacFarlane A, Mair FS, Potthoff S, Rapley T, Finch TL.   +12 more
europepmc   +1 more source

NPT再検討会議の成果と課題 NPT再検討会議の課題 : 日本の軍縮外交のために (被爆70年 : 核軍縮・不拡散特集)

, 2016
信将 秋山
openalex   +1 more source

Computational Characterization of the Role of LEM2/LaminA Interactions on the Stability of BAF‐Dimer Using Molecular Simulations

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The effect of the presence of the BAF‐binding LEM‐domain and LaminA Ig‐fold on the stability of the BAF dimer was studied qualitatively using non‐equilibrium pull simulations and quantitatively through the calculation of the potential of mean force profile along BAF–BAF separation distance.
Aswin Vinod Muthachikavil, Alexander von Appen, Thomas D. Kühne   +2 more
wiley   +1 more source

An integrated molecular-thermodynamic framework for analyzing nanobubbles in supersaturated liquids. [PDF]

RSC Adv
Ghamartale A, Shahini E, Jain A, Manica R, Berg P, Tang T.   +5 more
europepmc   +1 more source

Allosteric Regulation of RNA Affinity by Motif V‐VI Coupling in West Nile Virus NS3 Helicase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The rise of flaviviral diseases, including West Nile virus (WNV), presents a growing threat to global public health and underscores the urgent need for new therapeutic strategies. The non‐structural protein 3 helicase (NS3h) of the Orthoflavivirus genus, including WNV, is essential for viral replication and a promising antiviral target ...
Priti Roy, Martin McCullagh
wiley   +1 more source

EquilibraTor streamlines molecular dynamics simulations in a single execution. [PDF]

Comput Struct Biotechnol J
Cediel-Becerra JDD, Silva JCF, Dias R.
europepmc   +1 more source