Results 61 to 70 of about 39,133 (289)

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Rethinking the NPT [PDF]

, 1995
The Treaty on the Nonproliferation of Nuclear Weapons (NPT), with over 160 parties, is the most widely adhered to arms control treaty in history, but it has been criticized throughout its existence. In 1995, it is confronting a fateful decision on its extension and its application to today`s world.
openaire   +2 more sources

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model

Mediators of Inflammation, 2015
In a swine model of ischemia/reperfusion injury coupled with sepsis, we have previously shown attenuation of secondary organ injury and decreased mortality with negative pressure therapy (NPT).
Kenneth C. Norbury, Mary Pat Moyer
doaj   +1 more source

Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance

Advanced Science, EarlyView.
Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao, Xianqun Hu, Ying Wu, Xiang Zhou, Bo Zhang, Song Yang   +5 more
wiley   +1 more source

High‐Performance Quasi‐Solid‐State Calcium‐Ion Batteries from Redox‐Active Covalent Organic Framework Electrolytes

Advanced Science, EarlyView.
Quasi‐solid‐state calcium‐ion batteries (QSSCIBs) employing redox‐active covalent organic frameworks (COFs) based electrolytes are developed. The COFs’ crystalline porous structures, featuring aligned carbonyl groups, enabled high Ca2⁺ conductivity, supported by molecular dynamics simulations of the ion transport mechanism.
Zhuoyu Yin, Jixin Wu, Ye Tian, Yufei Yuan, Muhua Gu, Lei Cheng, Yanming Wang, Yoonseob Kim   +7 more
wiley   +1 more source

Assessment of Allergen-Induced Respiratory Hyperresponsiveness before the Prescription of a Specific Immunotherapy

Allergy & Rhinology, 2015
Background Asymptomatic sensitization is a frequent condition that must be considered before the indication of allergic-specific immunotherapy. Objective The aim of this study was to appreciate and correlate the local and spirometric changes elicited by ...
Celso Eduardo Olivier M.D., Ph.D., Daiana Guedes Pinto Argentão B.Biomed, Regiane Patussi dos Santos Lima B.Biomed, Mariana Dias da Silva Pharm.D., Raquel Acácia Pereira Gonçalves dos Santos B.S.N., Natalia Fabbri D.Physio, Ph.D.   +5 more
doaj   +1 more source

The prognostic value of the NPT test combined with amplitude integrated electroencephalogram in children with VE and its bioreliability analysis [PDF]

Journal of Medical Biochemistry
Background: Viral encephalitis (VE) is one of the common diseases of children with intracranial infection, it has come on urgent, progress is fast, and the clinical features of severe cases may even lead to disability, death, and other serious adverse ...
Liu Yinghong, Li Wenjuan, Wang Chaohai, Chen Shuyun, Wang Gaiqing   +4 more
doaj   +1 more source

From NPT to TPNW: From Non-proliferation to Prohibition of Nuclear Weapons [PDF]

, 2023
Barbara Gallo
openalex   +1 more source