Results 81 to 90 of about 39,133 (289)
Advanced Science, EarlyView.An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li +11 more
wiley +1 more source
Advanced Science, EarlyView.This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu +14 more
wiley +1 more source
Advanced Science, EarlyView.The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li +10 more
wiley +1 more source
Advanced Science, EarlyView.Inspired by antifreeze proteins and ion channels in polar fish, β‐cyclodextrin–grafted hyperbranched polyglycerol (CDhPG) mimics interfacial water structuring and ion dehydration. The ice‐matching hydroxyl spacing (2.76 Å) enables IRI activity, while dendritic cavities tailor Zn2+ solvation and enhance low‐temperature conductivity for sustainable ...
Xiaoping Li +10 more
wiley +1 more source
Is the NPT Still Relevant? – How to Progress the NPT’s Disarmament Provisions
Journal for Peace and Nuclear Disarmament, 2019 The Nuclear Non-Proliferation Treaty is the cornerstone of the global non-proliferation regime. However, the question is the NPT still relevant? may suggest that the importance of NPT has been forgotten.
John Carlson
doaj +1 more source
Advanced Science, EarlyView.Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan +6 more
wiley +1 more source