Results 51 to 60 of about 565 (91)
Long non‐coding RNAs as key regulators of neurodegenerative protein aggregation
Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.Abstract The characteristic events in neurodegenerative diseases (NDDs) encompass protein misfolding, aggregation, accumulation, and their related cellular dysfunction, synaptic function loss. While distinct proteins are implicated in the pathological processes of different NDDs, the process of protein misfolding and aggregation remains notably similar
Qi Xu +4 more
wiley +1 more source
Global Challenges, Volume 9, Issue 1, January 2025.This review focuses on the challenges in the treatment of hepatocellular carcinoma (HCC) and how lipid nanoparticles (LNPs) have demonstrated considerable efficacy in the delivery of nucleic acid‐based therapeutics and have shown potential in chemotherapy, immunotherapy, and gene therapy.
Mingxuan Zhang +3 more
wiley +1 more source
Molecular Oncology, Volume 18, Issue 11, Page 2801-2813, November 2024.Our study performed parallel genomic and epigenomic profiling of plasma cfDNA from pancreatic cancer patients and healthy individuals. A diagnostic model with six methylation markers achieved high sensitivity (88.7%) and specificity (96.8%); performance was further improved when combined with CA19‐9 (sensitivity: 95.7%; specificity: 93.3%).
Guochao Zhao +16 more
wiley +1 more source
LncRNA EIF3J‐DT promotes chemoresistance in oral squamous cell carcinoma
Oral Diseases, Volume 30, Issue 8, Page 4909-4920, November 2024.Abstract Objectives This study aimed to screen oral squamous cell carcinoma (OSCC) diagnostic and prognostic candidates and investigate the potential functions and mechanisms of candidates in the chemoresistance of OSCC cell lines. Materials and Methods Differential expression profiling of lncRNA was performed in a large cohort of OSCC patients from ...
Seon Hyun Kim +4 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 28, Issue 17, September 2024.Abstract Long non‐coding RNAs (lncRNAs) play an important role in the progression of gastric cancer (GC), but its specific regulatory mechanism remains to be further studied. We previously identified that lncRNA B3GALT5‐AS1 was upregulated in GC serum. Here, we investigated the functions and molecular mechanisms of B3GALT5‐AS1 in GC tumorigenesis.
Wei Feng +4 more
wiley +1 more source
Journal of Diabetes, Volume 16, Issue 2, February 2024.Highlights Long noncoding RNAs (lncRNAs) may be associated with type 2 diabetes mellitus (T2DM) and related complications. We performed a systematic review and meta‐analysis of related published literature. LncRNAs had T2DM diagnostic area under the curve of 0.84, sensitivity of 0.79, and specificity of 0.75.
Xuee Su +4 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 28, Issue 3, February 2024.Abstract Recently, long noncoding RNAs (lncRNAs) have been applied as biomarkers for melanoma patients. In this systematic review and meta‐analysis, we investigated the diagnostic and prognostic value of lncRNAs. We used the keywords ‘lncRNA’ and ‘melanoma’ to search databases for studies published before June 14th, 2023.
Mahdi Masrour +4 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
lncRNA <i>NAS1</i> Deficiency Drives Cisplatin Resistance via NR2F1-Mediated TGFB1/NF-κB Signaling Axis in NSCLC. [PDF]
Cancers (Basel)Lin X +5 more
europepmc +1 more source
Noncoding RNAs, Vital Players in Breast Cancer Metastasis. [PDF]
Breast Cancer (Dove Med Press)Kang Y +5 more
europepmc +1 more source