Results 51 to 60 of about 410,492 (225)

Effects of sleep fragmentation on the arousability to resistive loading in NREM and REM sleep in normal men

, 2006
STUDY OBJECTIVE: In healthy subjects, arousability to inspiratory resistive loading is greater during rapid eye movement (REM) sleep compared with non-REM (NREM) sleep but is poorest in REM sleep in patients with sleep apnea.
Corinne Roth, Matthias Gugger, Gugger, Matthias, Bassetti, Claudio L, Mathis, Johannes, Claudio L. Bassetti, Johannes Mathis, Zavodny, Jeannette, Jeannette Zavodny, Neil J. Douglas, Douglas, Neil J, Roth, Corinne   +11 more
core   +1 more source

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, EarlyView.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source

Facilitating the timely diagnosis of Lennox–Gastaut syndrome: A checklist to support clinical practice

Epileptic Disorders, EarlyView.
Abstract Objective To develop and evaluate a simple‐to‐use checklist to support physicians with the timely diagnosis of Lennox–Gastaut syndrome (LGS). Methods A panel of 10 pediatric and adult epileptologists used the International League Against Epilepsy (ILAE) criteria for LGS classification and definition to develop seven questions for the checklist,
Nicola Specchio, Alexis Arzimanoglou, Stéphane Auvin, Antonio Gil‐Nagel, Lieven Lagae, Rima Nabbout, Susanne Schubert‐Bast, Adam Strzelczyk, Eugen Trinka, J. Helen Cross   +9 more
wiley   +1 more source

The fate of incoming stimuli during NREM sleep is determined by spindles and the phase of the slow oscillation

Frontiers in Neurology, 2012
The present study aimed at identifying the neurophysiological responses associated with auditory stimulation during non-rapid eye movement (NREM) sleep using simultaneous EEG/fMRI recordings.
Manuel eSchabus, Manuel eSchabus, Thien Thanh eDang-Vu, Dominik Philip Johannes Heib, Melanie eBoly, Martin eDesseilles, Gilles eVandewalle, Christina eSchmidt, Genevieve eAlbouy, Annabelle eDarsaud, Steffen eGais, Christian eDegueldre, Evelyne eBalteau, Christophe ePhillips, Andre eLuxen, Pierre eMaquet   +15 more
doaj   +1 more source

Lurasidone Suppresses Rapid Eye Movement Sleep and Improves Sleep Quality in Rats

Journal of Pharmacological Sciences, 2014
.: Patients with psychiatric disorders, including schizophrenia, are reported to suffer from sleep disorders. In this study, we investigated the effects of lurasidone, an atypical antipsychotic, on sleep architecture in rats using sleep ...
Takeshi Murai, Keiko Nakamichi, Isao Shimizu, Kazuhito Ikeda   +3 more
doaj   +1 more source

Revisiting the concept that interictal implies asymptomatic: Pulse wave amplitude drops uncover autonomic responses during generalized paroxysmal fast activities

Epilepsia, EarlyView.
Abstract Objective Interictal electroencephalographic (EEG) activities are generally considered asymptomatic. Pulse wave amplitude drop (PWAD) is a marker of autonomic nervous system (ANS) reactivity linked to cardiovascular risk. Generalized paroxysmal fast activity (GPFA) is a major EEG pattern in different epileptic conditions.
Julie Lévi‐Strauss, Valerio Frazzini, Claude Adam, Isabelle Gourfinkel‐An, Sophie Dupont, Vincent Navarro, Vi‐Huong Nguyen‐Michel   +6 more
wiley   +1 more source

Impaired glycinergic transmission in hyperekplexia: a model of parasomnia overlap disorder

Annals of Clinical and Translational Neurology, 2019
We report sleep phenotypes and polysomnographic findings in two siblings with a novel homozygous variant of the GLRA1 gene causing hereditary hyperekplexia (HH).
Régis Lopez, François Rivier, Jamel Chelly, Yves Dauvilliers   +3 more
doaj   +1 more source

Longitudinal trajectories of spectral power during sleep in middle-aged and older adults

Aging Brain, 2023
Age-related changes in sleep appear to contribute to cognitive aging and dementia. However, most of the current understanding of sleep across the lifespan is based on cross-sectional evidence. Using data from the Sleep Heart Health Study, we investigated
Chenlu Gao, Michael K. Scullin
doaj   +1 more source

Adeno‐associated virus‐mediated restoration of NaV1.1 in targeted brain regions ameliorates epilepsy in symptomatic Dravet syndrome mice

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a developmental and epileptic encephalopathy primarily caused by haploinsufficiency of the SCN1A gene, which encodes the alpha subunit of NaV1.1 voltage‐gated sodium channel. The disease manifests with febrile and spontaneous seizures, developmental delay, cognitive impairment, and increased risk of sudden ...
Martina Mainardi, Simone Brusco, Serena Gea Giannelli, Vania Broccoli, Gaia Colasante   +4 more
wiley   +1 more source

Labile sleep promotes awareness of abstract knowledge in a serial reaction time task

Frontiers in Psychology, 2015
Sleep has been identified as a critical brain state enhancing the probability of gaining insight into covert task regularities. Both non-rapid eye movement (NREM) and REM sleep have been implicated with offline re-activation and reorganization of ...
Roumen eKirov, Vasil eKolev, Rolf eVerleger, Juliana eYordanova   +3 more
doaj   +1 more source