Results 91 to 100 of about 844,158 (279)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Simulación de redes móviles ad hoc mediante ns-3 [PDF]
, 2014 Introducción a la herramienta de simulación de redes network simulator 3 (ns-3). Este simulador es una de los programas más utilizados en la actualidad para la simulación de redes de diversos tipos, desde las redes ad hoc a redes móviles.
Yuste-Delgado, Antonio
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Automating ns-3 experimentation in multi-host scenarios
Proceedings of the 2015 Workshop on ns-3, 2015 ns-3 is a flexible simulator whose capabilities go beyond running purely synthetic simulations in a local desktop. Due to its ability to run unmodified Linux applications, to execute in real time mode, and to exchange traffic with live networks, ns-3 can be combined with live hosts to run distributed simulations or to transparently integrate live and ...
Quereilhac, Alina +3 more
openaire +3 more sources
Fluid flow queue models for fixed-mobile network evaluation [PDF]
, 2019 A methodology for fast and accurate end-to-end KPI, like throughput and delay, estimation is proposed based on the service-centric traffic flow analysis and the fluid flow queuing model named CURSA-SQ.
Bernal Escribano, Álvaro
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
A module for Data Centric Storage in ns-3 [PDF]
, 2015 Demo in Workshop on ns-3 (WNS3 2015). 13 to 14, May, 2015. Castelldefels, Spain.Management of data in large wireless sensor networks presents many hurdles, mainly caused by the limited energy available to the sensors, and by the limited knowledge of the ...
Albano, Michele +2 more
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
The Supergravity Dual of the BMN Matrix Model
, 2004 We propose type IIA supergravity solutions dual to the 1/2 BPS vacua of the BMN matrix model. These dual solutions are analyzed using the Polchinski-Strassler method and have brane configurations of concentric shells of D2 branes (or NS5 branes) with ...
Lin, Hai
core +1 more source