Results 91 to 100 of about 104,757 (302)
Carbazole Framework as Functional Scaffold for the Design of Synthetic Receptors
Chemistry – A European Journal, EarlyView.Carbazole‐based receptors play a crucial role in supramolecular chemistry, due to their unique geometry, photophysical properties, strong hydrogen bonding features, and versatility. This review examines prominent examples, focusing on how structural modifications shape binding affinity and selectivity for various guests, showcasing the potential of ...
Alessio Carioscia +6 more
wiley +1 more source
Nerve growth factor receptors in equine synovial membranes vary with osteoarthritic disease severity
Journal of Orthopaedic Research, Volume 41, Issue 2, Page 316-324, February 2023., 2023 Abstract Nerve growth factor (NGF) is a neurotrophin that has been implicated in pain signaling, apoptosis, inflammation and proliferation. The resultant effects depend on interaction with two different receptors; tyrosine kinase A (TrkA) and p75NTR. NGF increases in synovial fluid from osteoarthritic joints, and monoclonal antibody therapy is trialed ...
Anna Kendall +2 more
wiley +1 more source
NSAIDs--should every prescription carry a government health warning? [PDF]
, 1987 R Cockel
openalex +1 more source
Osteosarcoma Cell and Osteosarcoma Stem Cell Potent Immunogenic Bi‐Nuclear Gallium(III) Complexes
Chemistry – A European Journal, EarlyView.Current treatment options are unable to benefit the majority of osteosarcoma patients with metastasized tumors (70–80% 5‐year fatality rate). Osteosarcoma stem cells (OSCs), a small sub‐population of osteosarcoma cells with stem cell‐like properties, are thought to play a role in the spread of osteosarcoma. In this manuscript, we report the first metal
Xiao Feng +5 more
wiley +1 more source
Consumption and awareness of students about nonsteroidal anti-inflammatory drugs
Current Issues in Pharmacy and Medical Sciences, 2014 Nonsteroidal anti-inflammatory drugs (NSAIDs) are used by millions of people worldwide to neutralize pain that is of different origin, as well as to treat fever and inflammation.
Wawryk-Gawda Ewelina +3 more
doaj +1 more source
NSAIDs and balanced analgesia [PDF]
Canadian Journal of Anaesthesia, 1993 Anaesthetists have changed their drug regimens several times in the last few decades. Today, anaesthesia is most frequently carried out with a "balanced" combination of agents to achieve optimal surgical anaesthesia and enhance recovery. Similarly, analgesia, one of the comerstones of anaesthesia, is increasingly considered with a combination of ...
openaire +3 more sources
Highly‐Selective Electrochemical Decarboxylative Late‐Stage Functionalization of Amino Acids
Chemistry – A European Journal, EarlyView.Electrochemical decarboxylative late‐stage functionalization of the C‐ or N‐terminus of natural amino acids is presented. Metal and catalyst‐free protocol widely explored the synthesis of hindered ethers, amines, or di‐peptide. Abstract A unified electrochemical decarboxylative strategy for the site‐selective construction of carbon‐heteroatom bonds is ...
Adrija Ghosh +4 more
wiley +1 more source
ChemMedChem, Accepted Article.The cylcooxygenase isoforms COX‐1 and COX‐2 are involved in the production of prostaglandins in physiological and pathological processes. The overexpression of COX‐2 under inflammatory conditions as well as its role in cancer and neurodegenerative diseases necessitates the need to develop and improve non‐steroidal anti‐inflammatory drugs.
Lea Ueberham +8 more
wiley +1 more source
High-dimensional multiple imputation (HDMI) for partially observed confounders including natural language processing-derived auxiliary covariates [PDF]
arXivMultiple imputation (MI) models can be improved by including auxiliary covariates (AC), but their performance in high-dimensional data is not well understood. We aimed to develop and compare high-dimensional MI (HDMI) approaches using structured and natural language processing (NLP)-derived AC in studies with partially observed confounders.
arxiv