Results 131 to 140 of about 365,877 (337)

Cryoablation Activates the cGAS–STING‐CXCL10 Axis in Macrophages to Enhance Anti‐Tumor Immunity in NSCLC

Advanced Science, EarlyView.
Tumor dsDNA released by cryoablation is taken up by macrophages, activating the cGAS‐STING signaling pathway. This leads to an expansion of the CXCL10+ macrophage pool and increased secretion of CXCL10, which in turn recruits CXCR3+ T cells from draining lymph nodes into the tumor microenvironment to exert anti‐tumor effects.
Xinxin Zhi, Zhengcao Xing, Libo Luo, Jiale Wang, Xinyu Liu, Jia Yu, Jizhong Yin, Bin Chen, Yiwei Liu, Hui Sun, Guanghui Gao, Lei Wang, Xiaoxia Chen, Fei Li, Hu Ma, Lin Wang, Shuo Yang, Shengxiang Ren   +17 more
wiley   +1 more source

Long Noncoding RNA LINC01426 Sequesters microRNA-519d-5p to Promote Non-Small Cell Lung Cancer Progression by Increasing ETS1 Expression

Cancer Management and Research, 2020
Jixin Dai,1 Bing Wang,2 Yueming Zhao,1 Xuerong Zuo,1 Hongxia Cui,1 Xi Chen,2 Xianhong Liu1 1Department of Oncology, Jilin Cancer Hospital, Changchun, Jilin 130000, People’s Republic of China; 2Department of Radiotherapy, Jilin Cancer Hospital ...
Dai J, Wang B, Zhao Y, Zuo X, Cui H, Chen X, Liu X   +6 more
doaj  

Supplementary Table from Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence–Enabled Studies of Acute Phosphoproteomic Changes

, 2023
Elizabeth A. Coker, Adam Stewart, Buğra Özer, Anna Minchom, Lisa Pickard, Ruth Ruddle, Suzanne Carreira, Sanjay Popat, Mary O’Brien, Florence I. Raynaud, Johann S. de Bono, Bissan Al‐Lazikani, Udai Banerji   +12 more
openalex   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Randomized phase II trial of osimertinib with or without local consolidation therapy (LCT) for patients with EGFR-mutant metastatic NSCLC (NORTHSTAR) [PDF]

, 2018
Yasir Y. Elamin, Mara B. Antonoff, C. Blakely, M. Baggstorm, Trever G. Bivona, Xiuning Le, Alexander V. Louie, Robert C. Doebele, Chad G. Rusthoven, P. Lee, Ramaswamy Govindan, Stephen G. Swisher, Vassiliki A. Papadimitrakopoulou, John V. Heymach, D.R. Gomez   +14 more
openalex   +1 more source

Table S2 from Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations

, 2023
Kazunori Aoki, Yukari Nishito, Noriko Motoi, Yasuhito Arai, Nobuyoshi Hiraoka, Tatsuhiro Shibata, Yukiko Sonobe, Yoko Kayukawa, Eri Hashimoto, Mina Takahashi, Etsuko Fujii, Takashi Nishizawa, Hironori Fukuda, Kana Ohashi, Kosuke Arai, Yukihiro Mizoguchi, Yukihiro Yoshida, Shun‐ichi Watanabe, Makiko Yamashita, Shigehisa Kitano, Hiromi Sakamoto, Yuki Nagata, Risa Mitsumori, Kouichi Ozaki, Shumpei Niida, Yae Kanai, Akiyoshi Hirayama, Tomoyoshi Soga, Toru Maruyama, Keisuke Tsukada, Nami Yabuki, M. Shimada, Takehisa Kitazawa, Osamu Natori, Noriaki Sawada, Atsuhiko Kato, Teruhiko Yoshida, Kazuki Yasuda, Hideaki Mizuno, Hiroyuki Tsunoda, Atsushi Ochiai   +40 more
openalex   +1 more source

PCN41 Cost-Effectiveness of Pembrolizumab in Combination with Chemotherapy in the 1ST LINE Treatment of Metastatic NSCLC in Taiwan [PDF]

, 2020
R. Insinga, Ashwini Arunachalam, Siyuan Lei, Yixue Shao, Siyi Tan, C. Spiteri   +5 more
openalex   +1 more source

P09.11 Nutritional Risk Status Predicts Overall Survival of Mexican Patients with Advanced Non-Small-Cell Lung Cancer (NSCLC) [PDF]

, 2021
Saúl Campos-Gómez, J.J. Valdéz-Andrade, J. Esquivel-Gutierrez, Emigdio Jaimes-Alpízar, G. Pacheco-Cuellar, K. Campos-Gomez   +5 more
openalex   +1 more source

SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibit Lung Tumor Growth and Metastasis

Advanced Science, EarlyView.
This study highlights the capacity for tumor suppressor SATB2 to recruit HDAC3 and catalyze histone H3K9 delactylation, thereby repress transcription of the oncogene LCN2. This novel epigenetic‐metabolic axis inhibits the growth and metastasis of non‐small cell lung cancer, delineating a new mechanistic pathway with potential therapeutic relevance ...
Ting Wen, Lihua Yang, Shuang Cai, Yunxia Liu, Jianan Fan, Peng Wu, Beibei Gao, Xiaoge Xie, Hong Sun, Sida Qin, Qiao Yi Chen   +10 more
wiley   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source