Results 151 to 160 of about 34,742 (282)

Sparse Contribution Plot for Fault Diagnosis of Multimodal Chemical Processes ★ ★This work was partially supported by the NSFC under grants 61210012, 61290324, 61490700, 61473164

IFAC-PapersOnLine, 2015
Chao Ning, Maoyin Chen, Donghua Zhou
openaire   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

A hierarchical urban network control with integration of demand balance and traffic signal coordination**This work is supported in part by the National Science Foundation of China (Grant No. 61433002, 61521063, 61374110, 61473288), the Beijing Natural Science Foundation (Grant No. 4142055), NSFC International Cooperation Project (Grant No. 71361130012).

IFAC-PapersOnLine, 2016
Zhao Zhou, Shu Lin, Yugeng Xi, Dewei Li, Jun Zhang   +4 more
openaire   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Rhodium-Catalyzed Desymmetric Addition of Boronic Acids to Malononitriles. [PDF]

J Am Chem Soc
Zhang M, Zhang Q, Cao J, Wang JJ, Wang J, Huang Z.   +5 more
europepmc   +1 more source

Grant counts, funding amount, and academic productivity: causal evidence from the NSFC

Studies in Higher Education
Xiaojie Fan, Hanyu Qin, Monique Wangyi Dai   +2 more
openaire   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Facile Synthesis of Nonalternant π-Conjugated Azaborines via Boron-Deleting Annulation. [PDF]

J Am Chem Soc
Zhuang W, Shiri F, Hung FF, Wang Z, Zhang D, Duan L, Che CM, Lin Z, Liu J.   +8 more
europepmc   +1 more source

Recursive Identification of Hammerstein With Noisy Observations**The work was supported by the NSFC under Grants 61273193, 61120106011, 61134013, the 973 program of China under grant No.2014CB845301, and the National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, and in part by the Army Research Office under grant W911NF-12-1-0223.http://www.hamecmopsys.ens2m.fr

IFAC-PapersOnLine, 2015
Biqiang Mu, Chen Han-Fu, Le Yi Wang, George Yin   +3 more
openaire   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source