Results 131 to 140 of about 14,750 (231)

Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3 [PDF]

, 2020
David N. Frick, Rajdeep S. Virdi, Nemanja Vuksanovic, Narayan Dahal, N.R. Silvaggi   +4 more
openalex   +1 more source

Identification of Three Novel Linear B-Cell Epitopes in Non-Structural Protein 3 of Porcine Epidemic Diarrhea Virus Using Monoclonal Antibodies

Viruses
Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic swine coronavirus that causes diarrhea and high mortality in piglets, resulting in significant economic losses within the global swine industry.
Mingjun Ye, Huixin Zhu, Zhen Yang, Yanni Gao, Juan Bai, Ping Jiang, Xing Liu, Xianwei Wang   +7 more
doaj   +1 more source

New insights on the role of paired membrane structures in coronavirus replication [PDF]

, 2015
The replication of coronaviruses, as in other positive-strand RNA viruses, is closely tied to the formation of membrane-bound replicative organelles inside infected cells. The proteins responsible for rearranging cellular membranes to form the organelles
Al-Mulla, Angelini, Angelini, Barajas, Belov, Benjamin W. Neuman, Bernasconi, Bestebroer, Calì, Chatterjee, Cottam, Cottam, Deng, Edwardson, Egger, Fontana, Gadlage, Gillespie, Gosert, Guix, Hagemeijer, Hagemeijer, Hagemeijer, Hawaa Al-Mulla, Hsu, Hurst, Imbert, Johnson, Kanjanahaluethai, Knoops, Knoops, Knoops, Kopek, Kopek, Krogh, Lauber, Lesemann, Lundin, Magliano, Maier, Maier, Maier, Manolaridis, Medina, Mendez, Miller, Monastyrska, Moreira, Neuman, Neuman, Neuman, Noack, Oostra, Oostra, Pan, Pedersen, Philip V’kovski, Pol, Posthuma, Prentice, Ratia, Reggiori, Richards, Richards, Roberts, Romero-Brey, Romero-Brey, Roosendaal, Rudzinska-Langwald, Saikatendu, Salonen, Sawicki, Schwartz, Schwartz, Serrano, Serrano, Sharma, Snijder, Snijder, Spann, Sparks, Stokes, Suhy, Tan, Teterina, Thuy, Ulasli, van Kasteren, Verheije, Volker Thiel, von Brunn, Welsch, Wojdyla, Wojdyla, Wood, Xu, Xu, Zhao, Zhong, Zirkel   +99 more
core   +1 more source

β-Carboline alkaloids induce structural plasticity and inhibition of SARS-CoV-2 nsp3 macrodomain more potently than remdesivir metabolite GS-441524: computational approach

, 2021
Yusuf Oloruntoyin Ayipo, Yahaya Sani Najib, Halimah Funmilayo Babamale, Iqrar Ahmad, Harun Patel, Mohd Nizam Mordi   +5 more
openalex   +2 more sources

YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses

Journal of Virology
Chikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential ...
Zhen-Qi Li, Li-Xin Zhao, Su-Yun Wang, Chu-Yu Hu, Yan-Yi Wang, Yan Yang   +5 more
doaj   +1 more source

Computational approach to study the synthesis of noscapine and potential of stereoisomers against nsP3 protease of CHIKV

Heliyon, 2019
Chikungunya fever is a major public health issue in India affecting millions of people and occurs due to Chikungunya. Chikungunya virus (CHIKV) is a single stranded RNA virus from the family of Togaviridae and genus alpha virus.
Prashant Singh, Durgesh Kumar, Vijay Kumar Vishvakarma, Parul Yadav, Abhilash Jayaraj, Kamlesh Kumari   +5 more
doaj   +1 more source

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.

PLoS Pathogens, 2019
G3BP-1 and -2 (hereafter referred to as G3BP) are multifunctional RNA-binding proteins involved in stress granule (SG) assembly. Viruses from diverse families target G3BP for recruitment to replication or transcription complexes in order to block SG ...
Benjamin Götte, Marc D Panas, Kirsi Hellström, Lifeng Liu, Baila Samreen, Ola Larsson, Tero Ahola, Gerald M McInerney   +7 more
doaj   +1 more source

Infect Genet Evol [PDF]

Group A rotaviruses are the major cause of severe gastroenteritis in the young of mammals and birds. This report describes characterization of an unusual G20P[28] rotavirus strain detected in a 24month old child from Suriname.

core  

Multi-targeting approach for nsp3, nsp9, nsp12 and nsp15 proteins of SARS-CoV-2 by Diosmin as illustrated by molecular docking and molecular dynamics simulation methodologies

, 2021
Sumit Kumar, Prem P. Sharma, Charu Upadhyay, Prakasha Kempaiah, Brijesh Rathi, Poonam Poonam   +5 more
openalex   +2 more sources

J Gen Virol [PDF]

We report the genome of a novel human triple-recombinant G4P[6-8_R] mono-reassortant strain identified in a stool sample from the Dominican Republic during routine facility-based rotavirus strain surveillance.

core