Results 111 to 120 of about 12,322 (192)

Porcine transmissible gastroenteritis virus inhibits NF-κB activity via nonstructural protein 3 to evade host immune system

Virology Journal, 2019
Background Transmissible gastroenteritis virus (TGEV), a member of the family Coronaviridae, causes lethal watery diarrhea in piglets. Previous studies have revealed that the coronaviruses develop various strategies to evade the host innate immunity ...
Yanan Wang, Aoying Sun, Yu Sun, Sijia Zhang, Tian Xia, Tiantian Guo, Zhenye Hao, Li Sun, Yanping Jiang, Xinyuan Qiao, Wen Cui, Lijie Tang, Yigang Xu, Yijing Li, Li Wang   +14 more
doaj   +1 more source

SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer, Fulya Erendor, Salih Sanlioglu   +2 more
wiley   +1 more source

Venezuelan equine encephalitis virus non-structural protein 3 dictates superinfection exclusion in mammalian cells

npj Viruses
Superinfection exclusion (SIE) prevents secondary infections of already infected cells. Arthritogenic alphaviruses induce SIE via early proteolytical cleavage of replicase precursor by non-structural protein 2 (nsP2).
Tessy A. H. Hick, Taja Zotler, Davita Bosveld, Corinne Geertsema, Monique M. van Oers, Gorben P. Pijlman   +5 more
doaj   +1 more source

The nsP3 macro domain is important for Sindbis virus replication in neurons and neurovirulence in mice [PDF]

, 2009
Sindbis virus (SINV), the prototype alphavirus, contains a macro domain in the highly conserved N-terminal region of nonstructural protein 3 (nsP3). However, the biological role of the macro domain is unclear.
Park, Eunhye, Griffin, Diane E.
core   +1 more source

Comparative Interactome Profiling of Nonstructural Protein 3 Across SARS-CoV-2 Variants Emerged During the COVID-19 Pandemic

Viruses
SARS-CoV-2 virus and its variants remain a global health threat, due to their capacity for rapid evolution. Variants throughout the COVID-19 pandemic exhibited variations in virulence, impacting vaccine protection and disease severity.
Valeria Garcia Lopez, Lars Plate
doaj   +1 more source

The importance of the 5'UTR length in NSP3- and poly(A)-dependent translation.

, 2016
BSRT7 cells expressing NSP3 (NSP3; black bars) or no NSP3 (NSP3-KO) (wo. NSP3; white bars) were electroporated with the indicated capped R-RNA molecule (lines 1–6) or capped -p(A)-RNA molecule (lines 7–10) and the standard RNA.
Cécile Laroche (842228), Didier Poncet (371932), Mariela Duarte (842231), Hilma Carolina Baron (842227), Matthieu Gratia (842225), Stéphane Pyronnet (842230), Patrice Vende (842226), Annie Charpilienne (371930), Emeline Sarot (842229)   +8 more
core   +1 more source

The rotaviral NSP3 protein stimulates translation of polyadenylated target mRNAs independently of its RNA-binding domain.

, 2009
International audienceThe non-structural protein 3 (NSP3) of rotaviruses is an RNA-binding protein that specifically recognises a 4 nucleotide sequence at the 3' extremity of the non-polyadenylated viral mRNAs.
Cosson, Bertrand, Legagneux, Vincent, Poncet, Didier, Paillard, Luc, Keryer-Bibens, Cécile, Osborne, Howard Beverley, Namanda-Vanderbeken, Allen   +6 more
core   +1 more source

Regulation of gene expression by the NSP1 and NSP3 non-structural proteins of rotavirus

, 2011
The role of the rotavirus non-structural proteins NSP1 and NSP3 in regulating cellular and viral mRNA translation has been investigated by examining the effect of added recombinant NSP3 on protein translation in a T7-based in vitro coupled transcription ...
Chung, K. T., M. A. McCrae, McCrae, Malcolm A., K. T. Chung   +3 more
core   +1 more source

FXR-nsP3 complexes bind viral G RNA in VEEV-infected cells.

, 2016
(A) Colocalization of VEEV nsP3-GFP fusion proteins with VEEV G RNA. Images are presented as MIP of 6 x-y sections (1 μm) through the middle plane on nucleus. Bars: 10 and 3 μm. (B) Colocalization of FXR1-GFP with VEEV G RNA.
Dal Young Kim (732823), Ivan Akhrymuk (2934816), Elena I. Frolova (732826), Josephine M. Reynaud (732822), Ilya Frolov (211903), Aliaksandra Rasalouskaya (732825), James A. Mobley (365303)   +6 more
core   +1 more source

Involvement of PRRSV NSP3 and NSP5 in the autophagy process

Virology Journal, 2019
Background Autophagy is an essential process in eukaryotic cells in which autophagosomes form to deliver cellular organelles and long-lived proteins to lysosomes for degradation. Many studies have recently identified the regulatory mechanisms involved in
Wei Zhang, Keren Chen, Yang Guo, Yaosheng Chen, Xiaohong Liu   +4 more
doaj   +1 more source