Results 111 to 120 of about 14,170 (209)

Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain

ChemBioChem, Volume 26, Issue 23, November 27, 2025.
Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).
Robin Krishnathas, Konstantin S. Mineev, Nikolaos K. Fourkiotis, Franck Touret, Christos Sideras‐Bisdekis, Aikaterini C. Tsika, Santosh Lakshmi Gande, Verena Linhard, Sridhar Sreeramulu, Frank Lennartz, Manfred S. Weiss, Bruno Coutard, Georgios A. Spyroulias, Harald Schwalbe   +13 more
wiley   +1 more source

Cryo-EM reveals a double oligomeric ring scaffold of the CHIKV nsP3 peptide in complex with the NTF2L domain of host G3BP1

mBio
Chikungunya virus (CHIKV) poses a severe threat to global public health. The interaction between CHIKV nsP3 and host G3BP1 is critical for viral replication. However, the exact structural mechanism of the nsP3–G3BP1 interaction is scarce. Here, we report
Yuanzhi Liu, Jie Wang, Yinze Han, Xiaoyan Xia, Rui Zeng, Xinyu Fan, Bo Zhang, Kaituo Wang, Jian Lei   +8 more
doaj   +1 more source

Venezuelan equine encephalitis virus non-structural protein 3 dictates superinfection exclusion in mammalian cells

npj Viruses
Superinfection exclusion (SIE) prevents secondary infections of already infected cells. Arthritogenic alphaviruses induce SIE via early proteolytical cleavage of replicase precursor by non-structural protein 2 (nsP2).
Tessy A. H. Hick, Taja Zotler, Davita Bosveld, Corinne Geertsema, Monique M. van Oers, Gorben P. Pijlman   +5 more
doaj   +1 more source

Directed Irradiation Synthesis as an Advanced Plasma Technology for Surface Modification to Activate Porous and “as-received” Titanium Surfaces [PDF]

, 2019
For the design of smart titanium implants, it is essential to balance the surface properties without any detrimental effect on the bulk properties of the material.
Allain, Jean Paul, Arias, Sandra L., Chen, Mike, Civantos, Ana, El-Atwani, Osman, Gordon, Emily, Pavón Palacio, Juan José, Rodríguez-Ortiz, José Antonio, Shetty, Akshath, Torres Hernández, Yadir, Walker, Emily   +10 more
core   +1 more source

Phenalene-phosphazene complexes: effect of exocyclic charge densities on the cyclotriphosphazene ring system [PDF]

, 1988
The synthesis and properties of a new series of 1,9-diamino-substituted phenalene complexes of the cyclotriphosphazene ring system is described. One of the compounds is shown to be amphoteric, and this behavior allows an examination of the response of ...
Chichester-Hicks, S. V., Haddon, R. C., Mayo, Stephen L.   +2 more
core   +1 more source

Antagonism of mosquito innate immunity by the chikungunya virus nsP3 protein

Access Microbiology, 2019
Chikungunya virus (CHIKV) is a re-emerging Alphavirus transmitted by Aedes mosquitos and causing fever, rash and chronic arthralgia. There are no vaccines or antiviral agents available for CHIKV therefore it is important to understand the molecular details of virus replication.
Jinchao Guo, Yanni Gao, Mark Harris
openaire   +1 more source

SARS-CoV2 Nsp3 protein triggers cell death and exacerbates amyloid β42-mediated neurodegeneration

Neural Regeneration Research
[INLINE:1] Infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) virus, responsible for the coronavirus disease 2019 (COVID-19) pandemic, induces symptoms including increased inflammatory response, severe acute respiratory ...
Aditi Singh, Anuradha Venkatakrishnan Chimata, Prajakta Deshpande, Soumya Bajpai, Anjali Sangeeth, Mrigendra Rajput, Amit Singh   +6 more
doaj   +1 more source

A duplex real-time reverse transcriptase polymerase chain reaction assay for detecting western equine and eastern equine encephalitis viruses [PDF]

, 2010
In order to establish an accurate, ready-to-use assay for simultaneous detection of Eastern equine encephalitis virus (EEEV) and Western equine encephalitis virus (WEEV), we developed one duplex TaqMan real-time reverse transcriptase polymerase chain ...
Xiaoping Kang, Yuchang Li, Hong Liu, Fang Lin, Xuyu Cai, Tingting Sun, Guohui Chang, Qingyu Zhu, Yinhui Yang   +8 more
core   +1 more source

Candidate New Rotavirus Species in Sheltered Dogs, Hungary [PDF]

, 2015
We identified unusual rotavirus strains in fecal specimens from sheltered dogs in Hungary by viral metagenomics. The novel rotavirus species displayed limited genome sequence homology to representatives of the 8 rotavirus species, A–H, and qualifies ...
Bányai, Krisztián, Farkas, Szilvia, Fehér, Enikő, Gellért, Ákos, Jakab, Ferenc, Martella, Vito, Marton, Szilvia, Mihalov-Kovács, Eszter, Oldal, Miklós   +8 more
core   +1 more source

Identification of Three Novel Linear B-Cell Epitopes in Non-Structural Protein 3 of Porcine Epidemic Diarrhea Virus Using Monoclonal Antibodies

Viruses
Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic swine coronavirus that causes diarrhea and high mortality in piglets, resulting in significant economic losses within the global swine industry.
Mingjun Ye, Huixin Zhu, Zhen Yang, Yanni Gao, Juan Bai, Ping Jiang, Xing Liu, Xianwei Wang   +7 more
doaj   +1 more source