Results 91 to 100 of about 9,079 (162)

Phenol and chromone compounds for in silico inhibition of nsP2 and nsP3 of Chikungunya virus

Pharmaceutical Science Advances
The rising concern about neglected tropical diseases imposes a global challenge, in this sense, this work brings 12 potential candidates based on chromone and phenol compounds to inhibit nsP2 and nsP3 of the Chikungunya virus (CHIKV), through molecular docking and ADMET evaluation.
Joan Petrus Oliveira Lima, Caio Henrique Alexandre Roberto, Matheus Nunes da Rocha, Victor Moreira de Oliveira, Rafael Melo Freire, Ralph Santos-Oliveira, Emmanuel Silva Marinho, Pedro de Lima Neto, Pierre Basílio Almeida Fechine   +8 more
openaire   +2 more sources

READDI protocol: Crystallisation of CHIKV nsP3 macrodomain v2

The crystallization protocol and buffer conditions used to obtain reproducible Chikungunya Virus NS3 macrodomain crystals suitable for XChem fragment screening.
Jasmin Aschenbrenner, Peter Marples, michael fairhead, Andre Schutzer de Godoy, Daren Fearon   +4 more
openaire   +1 more source

Identification of Three Novel Linear B-Cell Epitopes in Non-Structural Protein 3 of Porcine Epidemic Diarrhea Virus Using Monoclonal Antibodies

Viruses
Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic swine coronavirus that causes diarrhea and high mortality in piglets, resulting in significant economic losses within the global swine industry.
Mingjun Ye, Huixin Zhu, Zhen Yang, Yanni Gao, Juan Bai, Ping Jiang, Xing Liu, Xianwei Wang   +7 more
doaj   +1 more source

YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses

Journal of Virology
Chikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential ...
Zhen-Qi Li, Li-Xin Zhao, Su-Yun Wang, Chu-Yu Hu, Yan-Yi Wang, Yan Yang   +5 more
doaj   +1 more source

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery.

PLoS Pathogens, 2019
G3BP-1 and -2 (hereafter referred to as G3BP) are multifunctional RNA-binding proteins involved in stress granule (SG) assembly. Viruses from diverse families target G3BP for recruitment to replication or transcription complexes in order to block SG ...
Benjamin Götte, Marc D Panas, Kirsi Hellström, Lifeng Liu, Baila Samreen, Ola Larsson, Tero Ahola, Gerald M McInerney   +7 more
doaj   +1 more source

Decoding chikungunya virus non-structural protein 3 interacting partners in THP-1 derived infected macrophages through proteomic profiling

Frontiers in Virology
IntroductionChikungunya virus (CHIKV), an alphavirus transmitted by mosquitoes, has instigated several epidemics in recent years, sparking intensive efforts to understand its biology.
Priyanshu Srivastava, Nimisha Mishra, Sakshi Chaudhary, Sujatha Sunil   +3 more
doaj   +1 more source

Rapid differentiation of VLA1553 and wild-type ECSA chikungunya strains in the context of an IXCHIQ vaccination campaign. [PDF]

Emerg Microbes Infect
Pezzi L, Frumence E, Wesselmann K, Mollé G, Falgous L, Ayhan N, Klitting R, Durand GA, Grard G, Mosnier E, Gérardin P, Nougairède A, Charrel R, Jaffar-Bandjee MC, de Lamballerie X.   +14 more
europepmc   +1 more source

Synthesis and Biological Evaluation of Modified Peptide Derivatives Targeting the SARS-CoV‑2 Nsp3 Macrodomain (Mac1) Replication Domain. [PDF]

ACS Omega
Özmen Ö, Oruçoğlu B, Dingiş Birgül Sİ, Öztürk Civelek D, Gül Ş, Akdemir A, Sönmez F, Zengin Kurt B.   +7 more
europepmc   +1 more source

Generation of G9 genotype porcine rotavirus using reverse genetics system and its application for antiviral screen and vaccine development. [PDF]

Virol Sin
Han N, Tao R, Cheng X, Deng H, Wang J, Bian X, Zhou J, Zhu X, Sun M, Zhang X, Hu M, Guo R, Wang W, Ding S, Li B.   +14 more
europepmc   +1 more source

Research progress on the role of host factors in Chikungunya virus infection and intervention strategies. [PDF]

Virulence
Chen Y, Zhang K, Qi Z, Ding C.
europepmc   +1 more source