Results 91 to 100 of about 12,322 (192)

SARS‐CoV‐2 and Cancer Biology: Exploring the Mechanistic Links

Cancer Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background Five years after the emergence of SARS‐CoV‐2 and the declaration of the COVID‐19 pandemic, the long‐term implications of COVID‐19 for cancer biology remain incompletely understood. Beyond the major disruptions in cancer screening, diagnosis, and treatment observed worldwide, increasing attention has focused on whether SARS‐CoV‐2 ...
Andrea Orue, Alejandro Cornejo, Héctor Rafael Rangel   +2 more
wiley   +1 more source

High-resolution functional mapping of the venezuelan equine encephalitis virus genome by insertional mutagenesis and massively parallel sequencing. [PDF]

PLoS Pathogens, 2010
We have developed a high-resolution genomic mapping technique that combines transposon-mediated insertional mutagenesis with either capillary electrophoresis or massively parallel sequencing to identify functionally important regions of the Venezuelan ...
Brett F Beitzel, Russell R Bakken, Jeffrey M Smith, Connie S Schmaljohn   +3 more
doaj   +1 more source

Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A stepwise translational framework linking natural‐product discovery, computational prioritisation, experimental validation, lead optimisation and targeted delivery is proposed to advance antiviral design. ABSTRACT The COVID‐19 pandemic highlighted the role of rapid viral mutation and global connectivity in accelerating viral emergence and spread ...
Adedayo Ayodeji Lanrewaju, Abimbola Motunrayo Folami, Saheed Sabiu, Feroz Mahomed Swalaha   +3 more
wiley   +1 more source

Oligomeric assembly of the C-terminal and transmembrane region of SARS-CoV-2 nsp3

Journal of Virology
As for all single-stranded, positive-sense RNA (+RNA) viruses, intracellular RNA synthesis relies on extensive remodeling of host cell membranes that leads to the formation of specialized structures.
M. Babot, Yves Boulard, Samira Agouda, L. Pieri, Sonia Fieulaine, S. Bressanelli, Virginie Gervais   +6 more
semanticscholar   +1 more source

Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

Antiviral Research, 2017
The multi‐domain non‐structural protein 3 (Nsp3) is the largest protein encoded by the coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an essential component of the replication/transcription complex. It comprises various
Jian Lei, Y. Kusov, R. Hilgenfeld
semanticscholar   +1 more source

SARS‐CoV‐2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release

mLife, Volume 5, Issue 3, Page 339-354, June 2026.
Abstract The mechanism of SARS‐CoV‐2 egress predominantly governs the quantity and quality of progeny viruses, thereby significantly contributing to viral pathogenicity. However, the key factors influencing viral egress remain largely unclear. In this study, using transcription‐ and replication‐competent SARS‐CoV‐2 virus‐like‐particle (SARS‐CoV‐2 trVLP)
Fujun Qin, Chuang Yan, Zizheng Liu, Dianbing Wang, Huimin Zhong, Qiang Ding, Minghai Chen, Xian‐En Zhang   +7 more
wiley   +1 more source

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

bioRxiv, 2020
The SARS-CoV-2 macrodomain (Mac1) within the non-structural protein 3 (Nsp3) counteracts host-mediated antiviral ADP-ribosylation signalling. This enzyme is a promising antiviral target because catalytic mutations render viruses non-pathogenic.
M. Schuller, G. Correy, Stefan Gahbauer, D. Fearon, Taia Wu, R. E. Díaz, I. Young, L. C. Martins, Dominique H. Smith, U. Schulze-Gahmen, T. Owens, I. Deshpande, G. Merz, A. Thwin, J. Biel, J. Peters, M. Moritz, N. Herrera, H. Kratochvil, -. Q. S. B. Consortium, A. Aimon, J. Bennett, J. Brandão, A. Cohen, A. Dias, A. Douangamath, L. Dunnett, O. Fedorov, Matteo P. Ferla, M. Fuchs, T. Gorrie-Stone, J. Holton, Michael G. Johnson, T. Krojer, G. Meigs, A. Powell, J. Rack, V. Rangel, S. Russi, R. Skyner, Clyde A. Smith, A. Soares, J. Wierman, K. Zhu, N. Jura, A. Ashworth, J. Irwin, M. Thompson, J. Gestwicki, F. von Delft, B. Shoichet, J. Fraser, I. Ahel   +52 more
semanticscholar   +1 more source

Inhibitors Targeting SARS‐CoV‐2 Papain‐Like Protease: Screening, Design, Synthesis, and Biological Evaluation

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
In our study, we obtained both non‐covalent and covalent PLpro inhibitors. Additionally, the stable protein‐ligand interactions of the active compound were examined using advanced computational docking and molecular dynamics simulations. The non‐covalent inhibitor 2t showed antiviral activity with an EC50 of 2.89 µM, indicating its potential as a ...
Elena‐Oriana Iuga, Nilu Gone, Mariana Ortiz de Godoy, Gabriel Correa Verissimo, Giovanna de Jesus Agostinetto, Liam Urich, Nadine Krüger, Thales Kronenberger, Rafael Victorio Carvalho Guido, Anthony J. O’Donoghue, Stefan A. Laufer, Thanigaimalai Pillaiyar   +11 more
wiley   +1 more source

The Stop Codon after the nsp3 Gene of Ross River Virus (RRV) Is Not Essential for Virus Replication in Three Cell Lines Tested, but RRV Replication Is Attenuated in HEK 293T Cells

Viruses
A recombinant Ross River virus (RRV) that contains the fluorescent protein mCherry fused to the non-structural protein 3 (nsP3) was constructed, which allowed real-time imaging of viral replication.
C. Schmidt, J. Gerbeth, Christine von Rhein, Florian D. Hastert, B. Schnierle   +4 more
semanticscholar   +1 more source

VEEV nsP3 interaction with host IKKβ.

, 2014
A) IKKβ was immunoprecipitated from VEEV infected U87MGs and Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) was performed. Control immunoprecipitations were performed with an IgG antibody.
Fatah Kashanchi (45093), Charles Bailey (61646), Moushimi Amaya (524600), Soren Mogelsvang (524604), Aarthi Narayanan (166336), Valerie Calvert (524603), Cynthia de la Fuente (524602), Kylene Kehn-Hall (45085), Emanuel Petricoin (239314), Gavin Sampey (173411), Calvin Carpenter (209321), Svetlana Senina (173425), Kelsey Voss (524601), Claudius Mueller (209317)   +13 more
core   +1 more source