Results 1 to 10 of about 5,845 (181)

Recombinant Rotaviruses Rescued by Reverse Genetics Reveal the Role of NSP5 Hyperphosphorylation in the Assembly of Viral Factories [PDF]

Journal of Virology, 2019
Rotavirus (RV) replicates in round-shaped cytoplasmic viral factories, although how they assemble remains unknown. During RV infection, NSP5 undergoes hyperphosphorylation, which is primed by the phosphorylation of a single serine residue.
Guido Papa, Francesca Arnoldi, Elisabeth M Schraner   +2 more
exaly   +2 more sources

Analysis of rotavirus non-structural protein NSP5 by mass spectrometry reveals a complex phosphorylation pattern

Virus Research, 2010
Genomic replication and partial assembly of Rotavirus takes place in cytoplasmic viral structures called viroplasms. NSP5 is a viral phosphoprotein localized in viroplasms and its expression is imperative for viral cycle progress.
Pablo H Sotelo, Michael Schumann, Eberhard Krause   +2 more
exaly   +2 more sources

Characterization of SARS-CoV-2 protease NSP3 and NSP5 degradome.

Infectious diseases are serious threats to human health and economy in both developed and non-developed countries. They are the cause of approximately half of the death toll worldwide. Recently, a severe acute respiratory syndrome, named COVID-19 (coronavirus disease 2019), has spread across the globe and has been found to be caused by a novel strain ...
openaire   +1 more source

Coronavirus NSP5 protease cleaves CCDC50 to evade antiviral autophagy

Autophagy
Ke Li, Hongyun Wei, Wenqiu Yin, Peng Zhou, Hui Jin, Anan Jongkaewwattana, Sizhu Suolang, Hongbo Zhou, Rui Luo   +8 more
openaire   +1 more source

Structure and Inhibitor Development of Coronavirus Main Protease NSP5

Proceedings of the 1st International Conference on Biomedical Engineering and Food Science
openaire   +1 more source

E3 ubiquitin ligase FBXO22 inhibits SARS‐CoV‐2 replication via promoting proteasome‐dependent degradation of NSP5

Journal of Medical Virology
Zheng Zhang
exaly  

Development of a magnetic beads-based ligand fishing method for screening SARS-CoV-2 NSP5 inhibitors from complex herbal mixtures: Rosmarinus officinalis as a case study

Journal of Chromatography A
exaly  

A Gaussia luciferase reporter assay for the evaluation of coronavirus Nsp5/3CLpro activity

Scientific Reports
Human coronaviruses (hCoVs) infect millions of people every year. Among these, MERS, SARS-CoV-1, and SARS-CoV-2 caused significant morbidity and mortality and their emergence highlights the risk of possible future coronavirus outbreaks.
Frank Kirchhoff, Dorota Kmiec, Kirchhoff Frank   +2 more
exaly   +6 more sources

Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling Pathway

Microbiology Spectrum, 2022
Over the last 2 years, several global virus-host interactome studies have been published with SARS-CoV-2 proteins with the purpose of better understanding how specific viral proteins can subvert or utilize different cellular processes to promote viral ...
Zhe Ma, Zsolt Tóth
exaly   +5 more sources

An ATPase activity associated with the rotavirus phosphoprotein NSP5

Virology, 2007
Interactions between NSP5 and NSP2 drive the formation of viroplasms, sites of genome replication and packaging in rotavirus-infected cells. The serine-threonine-rich NSP5 transitions between hypo- and hyper-phosphorylated isomers during the replication cycle. In this study, we determined that purified recombinant NSP5 has a Mg2+-dependent ATP-specific
Eugenio Spencer, John T Patton
exaly   +4 more sources