Results 1 to 10 of about 12,594 (172)

Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner

Viruses, 2022
Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Kai Rausalu, Sanjay Basu, Luke Alphey
exaly   +3 more sources

Nsp2 replicase-mediated viral uncoating in porcine alveolar macrophages contributes to the attenuation of PRRSV-2 live attenuated vaccine [PDF]

Journal of Virology
Type 2 porcine reproductive and respiratory syndrome virus (PRRSV-2) poses a major threat to global swine production. While live attenuated vaccines (LAVs) remain the most effective countermeasure, the molecular mechanisms underlying PRRSV-2 attenuation ...
Yuan-Zhe Bai, Hu Xu, Yong-Gang Liu, Yue Sun, Shi-Jia Xu, Meng-Xin Wang, Qian Wang, Zhi-Jun Tian, Chao-Liang Leng, Gang Wang, Tong-Qing An, Xue-Hui Cai, Hong-Liang Zhang, Yan-Dong Tang   +13 more
doaj   +2 more sources

Inhibition of Chikungunya virus nsP2 protease in vitro by scorpion venom peptide pantinin-1. [PDF]

PLoS ONE
Climate change has facilitated the spread of arboviruses like the Chikungunya virus (CHIKV). CHIKV, a re-emerging virus from the Togaviridae family, has caused numerous global outbreaks.
Mohammadamin Mastalipour, Mônika Aparecida Coronado, Jorge Enrique Hernández González, Dieter Willbold, Raphael Josef Eberle   +4 more
doaj   +2 more sources

Immunological Features of the Non-Structural Proteins of Porcine Reproductive and Respiratory Syndrome Virus [PDF]

Viruses, 2015
Porcine reproductive and respiratory syndrome virus (PRRSV) is currently one of the most important viruses affecting the swine industry worldwide. Despite the large number of papers published each year, the participation of non-structural proteins (nsps)
Edgar Rascón-Castelo, Alexel Burgara-Estrella, Enric Mateu, Jesús Hernández   +3 more
doaj   +6 more sources

A Natural Recombinant NADC30-Like PRRSV Strain in China: Intersection of CH-1a, QYYZ, and JXA1 Lineages. [PDF]

Transbound Emerg Dis
Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major threat to global swine production. In this study, a novel strain (PRRSV‐AH1) was isolated during a respiratory disease outbreak at a commercial swine operation in Anhui Province, China. Viral replication in MARC‐145 cells was confirmed by observing cytopathic effects (CPEs) and
Zhang H, Zhang C, Ma Y, Zhao Q, Wang X, Pan Q, Sun Y.   +6 more
europepmc   +2 more sources

The SHFV nsp2 and nucleocapsid proteins recruit G3BP1 to sites of viral replication, but stress granules are not induced by the infection [PDF]

Journal of Virology
Stress granules (SGs) are dynamic, cytoplasmic foci that form in response to environmental stresses, including viral infections, and function to restore cellular homeostasis by regulating mRNA translation, storage, and decay.
Ayisha A. Lavender, Oreoluwa Solanke, Hsin-Yao Tang, Hannah E. Peck, Daryll Vanover, Philip J. Santangelo, Margo A. Brinton   +6 more
doaj   +2 more sources

Rapid reconstruction of infectious bronchitis virus expressing fluorescent protein from its nsp2 gene based on transformation-associated recombination platform [PDF]

Journal of Virology
Traditional reverse genetics strategies for large-genome RNA viruses are hindered by multiple technical bottlenecks, including dependence on specific restriction enzyme sites, cumbersome multi-step cloning, and genetic instability of oversized DNA in ...
Yingfei Li, Linqing Duan, Lihua Tang, Min Huang, Ye Zhao, Guozhong Zhang, Jing Zhao   +6 more
doaj   +2 more sources

Getah virus nonstructural protein 2 suppresses interferon-beta production by interrupting interferon regulatory factor 3 activation [PDF]

Veterinary Research
Getah virus (GETV), a neglected and re-emerging mosquito-borne alphavirus, has become more serious and poses a potential threat to animal safety and public health.
Hua Liu, Zhao Qi, Lan Tian, Zhe Chen, Haonan Li, Le Liu, Sicong Liu, Shuai Li, Jiumeng Sun, Ying Shao, Xiangjun Song, Jian Tu, Liangqiang Zhu, Kezong Qi, Zhenyu Wang   +14 more
doaj   +2 more sources

NSP2 gene variation of the North American genotype of the Thai PRRSV in central Thailand [PDF]

Virology Journal, 2010
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major swine pathogen causing economic losses in the swine industry almost worldwide.
Amonsin Alongkorn, Nuntawan Na Ayudhya Suparlark, Kedkovid Roongtham, Thanawongnuwech Roongroje   +3 more
doaj   +4 more sources

A conserved motif within the NSP2 of SARS-CoV-2 is required for processing of the distal NSP1/NSP2 junction by NSP3 [PDF]

Scientific Reports
In 2019, the severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2) started to spread globally and caused the COVID-19 pandemic. SARS-CoV-2, like other members of the Coronaviridae, has a single-stranded, positive sense RNA genome about 30 kb
Thea Kristensen, Preben Normann, Graham J. Belsham   +2 more
doaj   +2 more sources