Results 1 to 10 of about 7,845 (134)

Heterodimerization of PRRSV replicase membrane proteins nsp2 and nsp3 regulates their cytoplasmic tail binding to viral RdRp domain for sgRNA synthesis [PDF]

Journal of Virology
Recruitment of viral RNA polymerase to replicase membrane proteins is a critical step for assembly of the replication and transcription complex (RTC) during the replication of positive-stranded RNA viruses.
Xueyan Liu, Yunhao Hu, Qiongqiong Zhou, Peng Gao, Yongning Zhang, Lei Zhou, Xinna Ge, Xin Guo, Jun Han, Hanchun Yang   +9 more
doaj   +2 more sources

Chikungunya virus nsP2: Insights into viral replication, pathogenesis, and therapeutic targeting [PDF]

Virulence
Chikungunya virus (CHIKV) poses a major global health challenge. Despite extensive research, effective antiviral treatments remain lacking, underscoring the urgent need for novel therapeutic strategies.
Shenghao Xu, Kaiyu Li, Qi Tan, Lei Yuan, Rong Huang, Yalan Feng, Kui Xu, Zhuang Zhu, Liyao Deng, Yang Deng, Yang Ren, Jian Yang, Xiaoyao Yang   +12 more
doaj   +2 more sources

The host protein SSR4 mediates PRRSV-induced endoplasmic reticulum stress via interaction with Nsp2 [PDF]

Journal of Virology
Porcine reproductive and respiratory syndrome (PRRS) is a major economic burden to the global swine industry. Here, we identify the endoplasmic reticulum (ER) translocon component SSR4 as a critical host factor co-opted by PRRSV.
Yingchao Li, Hongyan Gao, Zhong Liu, Man Lu, Yang Shen, Yajing Xing, Yu Wang, Xiaotong Wu, Pingping Yang, Hongjie Yuan, Yanmeng Hou, Yumei Cai, Baoquan Li, Yihong Xiao   +13 more
doaj   +2 more sources

Phosphorylation tunes strain-specific protein condensation during rotavirus replication organelle assembly [PDF]

The EMBO Journal
In many viruses, intrinsically disordered proteins (IDPs) drive the formation of replicative organelles via liquid–liquid phase separation (LLPS). In species A rotaviruses, the disordered protein NSP5 forms condensates with NSP2, but its high sequence ...
Julia Acker, Xinyu Wang, Alonso J Pardal, Daniel Desirò, Tanushree Agarwal, Alice Colyer, Aidan Tollervey, Rob Scrutton, Cyril Haller, Lee Sherry, Kadi L Saar, Ksenia Fominykh, Margaret L L Y Johncock, Sai Hou Chong, Rosie Murray, Jamie Terry, Jeremy D Schmit, Antonio N Calabrese, Tuomas P J Knowles, Alexander Borodavka   +19 more
doaj   +2 more sources

Inhibition of Chikungunya virus nsP2 protease in vitro by scorpion venom peptide pantinin-1. [PDF]

PLoS ONE
Climate change has facilitated the spread of arboviruses like the Chikungunya virus (CHIKV). CHIKV, a re-emerging virus from the Togaviridae family, has caused numerous global outbreaks.
Mohammadamin Mastalipour, Mônika Aparecida Coronado, Jorge Enrique Hernández González, Dieter Willbold, Raphael Josef Eberle   +4 more
doaj   +2 more sources

NOVEL MUTATIONS IN THE NON-STRUCTURE PROTEIN 2 OF SARS-CoV-2

Mediterranean Journal of Hematology and Infectious Diseases, 2023
Background: Mutation in the genome of SARS-CoV-2 may play a role in immune evasion, pathogenicity and speed of its transmission. Our investigation aimed to evaluate the mutations that exist in the nsp2.
Mohsen Nakhaei, Zohreh-Al-Sadat Ghoreshi, Mohammad Rezaei Zadeh Rukerd, Hedyeh Askarpour, Nasir   +4 more
doaj   +1 more source

Amino Acid Polymorphisms in the VHIID Conserved Motif of Nodulation Signaling Pathways 2 Distinctly Modulate Symbiotic Signaling and Nodule Morphogenesis in Medicago truncatula

Frontiers in Plant Science, 2021
Legumes establish an endosymbiotic association with nitrogen-fixing soil bacteria. Following the mutual recognition of the symbiotic partner, the infection process is controlled by the induction of the signaling pathway and subsequent activation of ...
Szilárd Kovacs, Lili Fodor, Agota Domonkos, Ferhan Ayaydin, Ferhan Ayaydin, Krisztián Laczi, Krisztián Laczi, Gábor Rákhely, Gábor Rákhely, Péter Kalo, Péter Kalo   +10 more
doaj   +1 more source

Nitrile-Specific Protein NSP2 and Its Interacting Protein MPK3 Synergistically Regulate Plant Disease Resistance in Arabidopsis

Plants, 2023
Glucosinolates and their degradation products have a wide range of actions and are important components of plant defense. NSP2 (nitrile-specific protein 2) is a key regulator in the breakdown process of glucosinolates.
Tingting Zhai, Jun Teng, Xintong Fan, Shaowei Yu, Chen Wang, Xingqi Guo, Wei Yang, Shuxin Zhang   +7 more
doaj   +1 more source

Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner

Viruses, 2022
Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko, Kai Rausalu, Sanjay Basu, Luke Alphey, Andres Merits   +4 more
doaj   +1 more source

The tail domain of PRRSV NSP2 plays a key role in aggrephagy by interacting with 14-3-3ε

Veterinary Research, 2020
Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is one of the most severe swine diseases that affects almost all swine-breeding countries. Nonstructural protein 2 (NSP2) is one of the most important viral proteins in the
Shengliang Cao, Jiaqi Liu, Guofei Ding, Qingyuan Shao, Bin Wang, Yingchao Li, Jian Feng, Yuzhong Zhao, Sidang Liu, Yihong Xiao   +9 more
doaj   +1 more source