Results 1 to 10 of about 420 (89)

NOVEL MUTATIONS IN THE NON-STRUCTURE PROTEIN 2 OF SARS-CoV-2

Mediterranean Journal of Hematology and Infectious Diseases, 2023
Background: Mutation in the genome of SARS-CoV-2 may play a role in immune evasion, pathogenicity and speed of its transmission. Our investigation aimed to evaluate the mutations that exist in the nsp2.
Mohsen Nakhaei, Zohreh-Al-Sadat Ghoreshi, Mohammad Rezaei Zadeh Rukerd, Hedyeh Askarpour, Nasir   +4 more
doaj   +1 more source

Amino Acid Polymorphisms in the VHIID Conserved Motif of Nodulation Signaling Pathways 2 Distinctly Modulate Symbiotic Signaling and Nodule Morphogenesis in Medicago truncatula

Frontiers in Plant Science, 2021
Legumes establish an endosymbiotic association with nitrogen-fixing soil bacteria. Following the mutual recognition of the symbiotic partner, the infection process is controlled by the induction of the signaling pathway and subsequent activation of ...
Szilárd Kovacs, Lili Fodor, Agota Domonkos, Ferhan Ayaydin, Ferhan Ayaydin, Krisztián Laczi, Krisztián Laczi, Gábor Rákhely, Gábor Rákhely, Péter Kalo, Péter Kalo   +10 more
doaj   +1 more source

Nitrile-Specific Protein NSP2 and Its Interacting Protein MPK3 Synergistically Regulate Plant Disease Resistance in Arabidopsis

Plants, 2023
Glucosinolates and their degradation products have a wide range of actions and are important components of plant defense. NSP2 (nitrile-specific protein 2) is a key regulator in the breakdown process of glucosinolates.
Tingting Zhai, Jun Teng, Xintong Fan, Shaowei Yu, Chen Wang, Xingqi Guo, Wei Yang, Shuxin Zhang   +7 more
doaj   +1 more source

Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner

Viruses, 2022
Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko, Kai Rausalu, Sanjay Basu, Luke Alphey, Andres Merits   +4 more
doaj   +1 more source

The tail domain of PRRSV NSP2 plays a key role in aggrephagy by interacting with 14-3-3ε

Veterinary Research, 2020
Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is one of the most severe swine diseases that affects almost all swine-breeding countries. Nonstructural protein 2 (NSP2) is one of the most important viral proteins in the
Shengliang Cao, Jiaqi Liu, Guofei Ding, Qingyuan Shao, Bin Wang, Yingchao Li, Jian Feng, Yuzhong Zhao, Sidang Liu, Yihong Xiao   +9 more
doaj   +1 more source

Potential Alphavirus Inhibitors From Phytocompounds – Molecular Docking and Dynamics Based Approach

Innovative Biosystems and Bioengineering, 2023
Background. Alphaviral diseases are an economic burden all over the world due to their chronicity and distribution worldwide. The glycoproteins E1 and E2 are important for binding to the surface of the host cell by interacting with the receptors and non ...
Maneesha Sharma, Anu Bansal, Shikha Suman, Neeta Raj Sharma   +3 more
doaj   +1 more source

Interactome profile of the host cellular proteins and the nonstructural protein 2 of porcine reproductive and respiratory syndrome virus. [PDF]

PLoS ONE, 2014
The nonstructural protein 2 (NSP2) is considered to be one of crucial viral proteins in the replication and pathogenesis of porcine reproductive and respiratory syndrome virus (PRRSV).
Li Wang, Lei Zhou, Han Zhang, Yan Li, Xinna Ge, Xin Guo, Kangzhen Yu, Hanchun Yang   +7 more
doaj   +1 more source

Full length and protease domain activity of chikungunya virus nsP2 differ from other alphavirus nsP2 proteases in recognition of small peptide substrates

Bioscience Reports, 2015
Alphavirus nsP2 proteins are multifunctional and essential for viral replication. The protease role of nsP2 is critical for virus replication as only the virus protease activity is used for processing of the viral non-structural polypeptide.
Chonticha Saisawang, Pornpan Sillapee, Kwanhathai Sinsirimongkol, Sukathida Ubol, Duncan R. Smith, Albert J. Ketterman   +5 more
doaj   +1 more source

In Silico Analysis of SARS-CoV-2 Non-Structural Proteins Reveals an Interaction with the Host’s Heat Shock Proteins That May Contribute to Viral Replications and Development

Current Issues in Molecular Biology, 2023
The non-structural protein 2 (NSP2) is an RNA-binding protein involved in coronavirus genome replication, and it often decreases human immune response to promote viral invasion and development.
Mthembu Yamkela, Zingisa Sitobo, Xolani H. Makhoba   +2 more
doaj   +1 more source

Full Genomic Analysis of New Variants of Porcine Reproductive and Respiratory Syndrome Virus Revealed Multiple Recombination Events Between Different Lineages and Sublineages

Frontiers in Veterinary Science, 2020
Porcine reproductive and respiratory syndrome virus (PRRSV) has had a devastating impact on the pig industry in China, and monitoring its genetic diversity is important for epidemiological surveillance and understanding its evolution.
Jinglong Wang, Siyuan Lin, Dongqun Quan, Hao Wang, Jiabin Huang, Yuxu Wang, Tongwei Ren, Kang Ouyang, Ying Chen, Weijian Huang, Tingrong Luo, Zuzhang Wei   +11 more
doaj   +1 more source