Results 1 to 10 of about 56,005 (221)

Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins. [PDF]

PLoS Pathogens, 2022
Autonomous parvoviruses encode at least two nonstructural proteins, NS1 and NS2. While NS1 is linked to important nuclear processes required for viral replication, much less is known about the role of NS2. Specifically, the function of canine parvovirus (
Salla Mattola, Kari Salokas, Vesa Aho, Elina Mäntylä, Sami Salminen, Satu Hakanen, Einari A Niskanen, Julija Svirskaite, Teemu O Ihalainen, Kari J Airenne, Minna Kaikkonen-Määttä, Colin R Parrish, Markku Varjosalo, Maija Vihinen-Ranta   +13 more
doaj   +9 more sources

Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2. [PDF]

PLoS Pathogens
Infection by chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes severe polyarthralgia and polymyalgia, which can last in some people for months to years.
Brian C Ware, M Guston Parks, Mariana O L da Silva, Thomas E Morrison   +3 more
doaj   +4 more sources

SARS-CoV-2 nonstructural protein 3 remodels the phosphorylation of target proteins via protein-protein interactions [PDF]

Microbiology Spectrum
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), triggered a global pandemic with a significant impact on human health. The molecular basis of its pathogenicity remains incompletely
Hui Yang, Daxin Peng, Luis Martinez-Sobrido, Chengjin Ye   +3 more
doaj   +3 more sources

Structural characterization of nonstructural protein 1 from SARS-CoV-2 [PDF]

iScience, 2021
Summary: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a single-stranded, enveloped RNA virus and the etiological agent of the current coronavirus disease 2019 pandemic.
Cameron Semper, Nobuhiko Watanabe, Alexei Savchenko   +2 more
doaj   +4 more sources

Porcine deltacoronavirus nonstructural protein 2 inhibits type I and III IFN production by targeting STING for degradation [PDF]

Veterinary Research
Porcine deltacoronavirus (PDCoV) is an enteropathogenic coronavirus that has been reported to use various strategies to counter the host antiviral innate immune response.
Xiqian Liu, Likai Ji, Yuqiang Cheng, Linghe Kong, Songhua Xie, Juan Yang, Jiaqi Chen, Zhaofei Wang, Jingjiao Ma, Hengan Wang, Yaxian Yan, Jianhe Sun   +11 more
doaj   +2 more sources

Getah virus nonstructural protein 2 suppresses interferon-beta production by interrupting interferon regulatory factor 3 activation [PDF]

Veterinary Research
Getah virus (GETV), a neglected and re-emerging mosquito-borne alphavirus, has become more serious and poses a potential threat to animal safety and public health.
Hua Liu, Zhao Qi, Lan Tian, Zhe Chen, Haonan Li, Le Liu, Sicong Liu, Shuai Li, Jiumeng Sun, Ying Shao, Xiangjun Song, Jian Tu, Liangqiang Zhu, Kezong Qi, Zhenyu Wang   +14 more
doaj   +2 more sources

Porcine transmissible gastroenteritis virus nonstructural protein 2 contributes to inflammation via NF-κB activation [PDF]

Virulence, 2018
Transmissible gastroenteritis virus (TGEV) infection causes acute enteritis in swine of all ages, and especially in suckling piglets. Small intestinal inflammation is considered a central event in the pathogenesis of TGEV infections, and nuclear factor ...
Li Wang, Xinyuan Qiao, Sijia Zhang, Yue Qin, Tiantian Guo, Zhenye Hao, Li Sun, Xiaona Wang, Yanan Wang, Yanping Jiang, Lijie Tang, Yigang Xu, Yijing Li   +12 more
doaj   +2 more sources

Letter to the Editor Regarding "An Overview on Serology and Molecular Tests for COVID-19: An Important Challenge of the Current Century (doi: 10.22034/iji.2021.88660.1894.)" [PDF]

Iranian Journal of Immunology, 2022
Recently in a review article by Mansourabadi et al. published in the Iranian Journal of Immunology, the authors described the serological and molecular tests for COVID-19 (1). The mentioned review considered helicase (Hel) as a structural protein of SARS-
Milad Zandi, Emad Behboudi, Mohammad Reza Shojaei, Saber Soltani, Hassan Karami   +4 more
doaj   +1 more source

SARS-CoV-2 Nucleocapsid Protein Has DNA-Melting and Strand-Annealing Activities With Different Properties From SARS-CoV-2 Nsp13

Frontiers in Microbiology, 2022
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world and has had a devastating impact on health and economy. The biochemical characterization of SARS-CoV-2 proteins is important for drug design
Bo Zhang, Yan Xie, Zhaoling Lan, Dayu Li, Junjie Tian, Qintao Zhang, Hongji Tian, Jiali Yang, Xinnan Zhou, Shuyi Qiu, Keyu Lu, Yang Liu, Yang Liu   +12 more
doaj   +1 more source

Human Respiratory Syncytial Virus NS2 Protein Induces Autophagy by Modulating Beclin1 Protein Stabilization and ISGylation

mBio, 2022
Paramyxoviruses such as respiratory syncytial virus (RSV) are the leading cause of pneumonia in infants, the elderly, and immunocompromised individuals.
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose   +8 more
doaj   +1 more source