Role of nonstructural proteins in the pathogenesis of SARS‐CoV‐2 [PDF]
Journal of Medical Virology, 2020 We read with great interest the study authored by Angeletti et al. regarding the role of nonstructural proteins nsp2 and nsp3 in the pathogenesis of COVID-191 . COVID-19 emerged in December 2019 in Wuhan City, Hubei Province, China and is caused by a novel viral variant belonging to the viral variant belonging to the Severe acute respiratory syndrome ...
Silva, Severino Jefferson Ribeiro +3 more
openaire +3 more sources
Identification of novel neutralizing determinants for protection against HCV
Hepatology, EarlyView., 2022 Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua +12 more
wiley +1 more source
Differentiation of Foot-and-Mouth Disease-Infected pigs from Vaccinated Pigs Using Antibody-Detecting Sandwich ELISA [PDF]
, 2011 The presence of serum antibodies for nonstructural proteins of the foot-and-mouth disease virus (FMDV) can differentiate FMDV-infected animals from vaccinated animals.
Aldo DEKKER +10 more
core +3 more sources
Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6
Nature Communications, 2023 Although the SARS-CoV-2 Omicron variant (BA.1) spread rapidly across the world and effectively evaded immune responses, its viral fitness in cell and animal models was reduced.
Taha Y. Taha +18 more
doaj +1 more source
NSP16 2′-O-MTase in Coronavirus Pathogenesis: Possible Prevention and Treatments Strategies
Viruses, 2021 Several life-threatening viruses have recently appeared, including the coronavirus, infecting a variety of human and animal hosts and causing a range of diseases like human upper respiratory tract infections.
Li-Jen Chang, Tsung-Hsien Chen
doaj +1 more source
Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus [PDF]
, 1987 The murine immediate-early (IE) protein pp89 is a nonstructural virus- encoded phosphoprotein residing in the nucleus of infected cells, where it acts as transcriptional activator.
Bertholet, Christine +4 more
core +4 more sources
SARS-CoV-2 Nonstructural Proteins 3 and 4 tune the Unfolded Protein Response
, 2023 AbstractCoronaviruses (CoV), including SARS-CoV-2, modulate host proteostasis through activation of stress-responsive signaling pathways such as the Unfolded Protein Response (UPR), which remedies misfolded protein accumulation by attenuating translation and increasing protein folding capacity.
Jonathan P. Davies +4 more
openaire +2 more sources
Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
, 2013 Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E. +4 more
core +2 more sources
Nuclear Import and Export of Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 [PDF]
Journal of Virology, 2007 ABSTRACT Many RNA viruses, which replicate predominantly in the cytoplasm, have nuclear components that contribute to their life cycle or pathogenesis. We investigated the intracellular localization of the multifunctional nonstructural protein 2 (nsP2) in mammalian cells infected with Venezuelan equine encephalitis virus (VEE), an ...
Stephanie A, Montgomery +1 more
openaire +2 more sources
Targeting SARS-CoV-2 Nonstructural Protein 15 Endoribonuclease: an in silico Perspective
Future Virology, 2021 The newly emerged human coronavirus, SARS-CoV-2, had begun to spread last year and sparked worldwide. In this study, molecular docking is utilized to test some previously approved drugs against the SARS-CoV-2 nonstructural protein 15 (Nsp15). We screened 23 drugs, from which three (saquinavir, valrubicin and aprepitant) show a paramount predicted ...
Shafi Mahmud +6 more
openaire +3 more sources