Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2. [PDF]
Proc Natl Acad Sci U S A, 2021 Significance The human respiratory syncytial virus (RSV) is a significant cause of lower respiratory tract infections in the young and the elderly and a substantial burden to global human health. Currently, there are no specific and effective treatments for RSV infections.
Pei J +11 more
europepmc +5 more sources
SARS-CoV-2 nonstructural protein 6 from Alpha to Omicron: evolution of a transmembrane protein
mBio, 2023 We recently reported that mutations in both the spike glycoprotein and nonstructural protein 6 (nsp6) were associated with attenuation of the SARS-CoV-2 Omicron BA.1 variant.
Shuchen Feng +4 more
doaj +3 more sources
Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2 [PDF]
Molecular Biomedicine, 2020 Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of a potentially fatal disease named coronavirus disease 2019 (COVID-19), has raised significant public health concerns globally.
Changhui Zhang +6 more
doaj +3 more sources
MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment [PDF]
Cell Reports, 2019 Summary: The mechanisms that regulate envelopment of HCV and other viruses that bud intracellularly and/or lack late-domain motifs are largely unknown. We reported that K63 polyubiquitination of the HCV nonstructural (NS) 2 protein mediates HRS (ESCRT-0 ...
Sathish Kumar +10 more
doaj +4 more sources
Cloning and Expression of Nonstructural Protein NS1 of Dengue Virus Serotype 2
Microbiology Indonesia, 2012 Early diagnosis of dengue virus (DENV) infection is affirmative for patient management and control of the disease. Detection of nonstructural-1 (NS1) antigen has been proven to provide early detection of DENV infection.
BETI ERNAWATI DEWI +5 more
doaj +2 more sources
Radicicol Inhibits Chikungunya Virus Replication by Targeting Nonstructural Protein 2. [PDF]
Antimicrob Agents Chemother, 2021 Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes a debilitating febrile illness characterized by persistent muscle and joint pain. The widespread distribution of transmission-competent vectors, Aedes species mosquitoes, indicates the potential risk of large-scale epidemics with high attack rates ...
Nam S +10 more
europepmc +4 more sources
Crystal structure of the CoV-Y domain of SARS-CoV-2 nonstructural protein 3
Scientific Reports, 2023 Replication of the coronavirus genome starts with the formation of viral RNA-containing double-membrane vesicles (DMV) following viral entry into the host cell.
Yunfeng Li +7 more
doaj +3 more sources
Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation [PDF]
Virology Journal, 2012 Background Nuclear factor-kappaB (NF-κB) is an inducible transcription factor that plays a key role in inflammation and immune responses, as well as in the regulation of cell proliferation and survival.
Fang Ying +7 more
doaj +3 more sources
Structure of nonstructural protein 1 from SARS-CoV-2 [PDF]
Journal of Virology, 2020 ABSTRACTThe periodic emergence of novel coronaviruses (CoVs) represents an ongoing public health concern with significant health and financial burden worldwide. The most recent occurrence originated in the city of Wuhan, China where a novel coronavirus (SARS-CoV-2) emerged causing severe respiratory illness and pneumonia.
Lauren K. Clark +2 more
openaire +3 more sources
Nonstructural protein 7 and 8 complexes of SARS-CoV-2 [PDF]
Protein Science, 2020 Abstract The pandemic outbreak of coronavirus disease 2019 (COVID-19) across the world has led to millions of infection cases and caused a global public health crisis. Current research suggests that SARS-CoV-2 is a highly contagious coronavirus that spreads rapidly through communities.
Changhui Zhang +4 more
openaire +3 more sources