Results 21 to 30 of about 7,712 (169)

Rotavirus NSP2: A Master Orchestrator of Early Viral Particle Assembly

Viruses
Rotaviruses (RVs) are 11-segmented, double-stranded (ds) RNA viruses and important causes of acute gastroenteritis in humans and other animal species.
Sarah L. Nichols, Cyril Haller, Alexander Borodavka, Sarah M. Esstman   +3 more
doaj   +3 more sources

A Novel Form of Rotavirus NSP2 and Phosphorylation-Dependent NSP2-NSP5 Interactions Are Associated with Viroplasm Assembly [PDF]

Journal of Virology, 2014
ABSTRACT Rotavirus (RV) replication occurs in cytoplasmic inclusions called viroplasms whose formation requires the interactions of RV proteins NSP2 and NSP5; however, the specific role(s) of NSP2 in viroplasm assembly remains largely unknown.
Jeanette M, Criglar, Liya, Hu, Sue E, Crawford, Joseph M, Hyser, James R, Broughman, B V Venkataram, Prasad, Mary K, Estes   +6 more
openaire   +2 more sources

Development of Sindbis Viruses Encoding nsP2/GFP Chimeric Proteins and Their Application for Studying nsP2 Functioning [PDF]

Journal of Virology, 2007
ABSTRACT Sindbis virus (SINV) is one of almost 30 currently known alphaviruses. In infected cells, it produces only a few proteins that function in virus replication and interfere with the development of the antiviral response. One of the viral nonstructural proteins, nsP2, not only exhibits protease and RNA helicase activities that are ...
Svetlana, Atasheva, Rodion, Gorchakov, Robert, English, Ilya, Frolov, Elena, Frolova   +4 more
openaire   +2 more sources

COVID‐2019: The role of the nsp2 and nsp3 in its pathogenesis [PDF]

Journal of Medical Virology, 2020
AbstractLast December 2019, a new virus, named novel Coronavirus (COVID‐2019) causing many cases of severe pneumonia was reported in Wuhan, China. The virus knowledge is limited and especially about COVID‐2019 pathogenesis. The Open Reading Frame 1ab (ORF1ab) of COVID‐2019 has been analyzed to evidence the presence of mutation caused by selective ...
Silvia Angeletti, Domenico Benvenuto, Martina Bianchi, Marta Giovanetti, Stefano Pascarella, Massimo Ciccozzi   +5 more
openaire   +3 more sources

Cryoelectron Microscopy Structures of Rotavirus NSP2-NSP5 and NSP2-RNA Complexes: Implications for Genome Replication [PDF]

Journal of Virology, 2006
ABSTRACT The replication and packaging of the rotavirus genome, comprising 11 segments of double-stranded RNA, take place in specialized compartments called viroplasms, which are formed during infection and involve a coordinated interplay of multiple components.
Xiaofang, Jiang, Hariharan, Jayaram, Mukesh, Kumar, Steven J, Ludtke, Mary K, Estes, B V Venkataram, Prasad   +5 more
openaire   +2 more sources

Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction [PDF]

Viruses, 2019
The papain-like cysteine protease 2 (PLP2) within the N-terminus of the porcine reproductive and respiratory syndrome virus (PRRSV) nsp2 replicase protein specifies a deubiquitinating enzyme (DUB), but its biochemical properties and the role in infection have remained poorly defined.
Shaochuan Zhou, Xinna Ge, Can Kong, Teng Liu, Aijing Liu, Peng Gao, Jiangwei Song, Lei Zhou, Xin Guo, Jun Han, Hanchun Yang   +10 more
openaire   +3 more sources

1,3-Thiazolbenzamide Derivatives as Chikungunya Virus nsP2 Protease Inhibitors [PDF]

ACS Omega, 2021
Chikungunya fever results from an infection with Chikungunya virus (CHIKV, genus Alphavirus) that is prevalent in tropical regions and is spreading fast to temperate climates with documented outbreaks in Europe and the Americas. Currently, there are no available vaccines or antiviral drugs for prevention or treatment of Chikungunya fever.
Larisa Ivanova, Kai Rausalu, Eva Žusinaite, Jaana Tammiku-Taul, Andres Merits, Mati Karelson   +5 more
openaire   +4 more sources

Genetic analysis of porcine productive and respiratory syndrome virus between 2013 and 2014 in Southern parts of China: identification of several novel strains with amino acid deletions or insertions in nsp2

BMC Veterinary Research, 2019
Background Porcine respiratory and reproductive syndrome virus (PRRSV) is one of the most economically significant pathogens in the Chinese swine industry. ORF5 and nsp2 are highly variable regions of the PRRSV genome.
Shaofeng Hong, Ying Wei, Siyuan Lin, Jiabing Huang, Wei He, Jing Yao, Ying Chen, Ouyang Kang, Weijian Huang, Zuzhang Wei   +9 more
doaj   +1 more source

The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex

iScience, 2022
Summary: There is an urgent need for a molecular understanding of how SARS-CoV-2 influences the machineries of the host cell. Herein, we focused our attention on the capacity of the SARS-CoV-2 protein NSP2 to bind the human 4EHP-GIGYF2 complex, a key ...
Limei Zou, Clara Moch, Marc Graille, Clément Chapat   +3 more
doaj   +1 more source

Genetic Variability and Recombination of the NSP2 Gene of PRRSV-2 Strains in China from 1996 to 2021

Veterinary Sciences, 2023
Porcine reproductive and respiratory syndrome (PRRS) is one of the most serious infectious diseases that detrimentally affects the pig industry worldwide. The disease, which is typically difficult to control, is an immunosuppressive disease caused by the
Hang Zhang, Qin Luo, Yajie Zheng, Huiyang Sha, Gan Li, Weili Kong, Liangzong Huang, Mengmeng Zhao   +7 more
doaj   +1 more source