Results 21 to 30 of about 12,594 (172)

Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]

, 2018
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel, Kasvandik, Sergo, Lulla, Aleksei, Lulla, Valeria, McInerney, Gerald M., Merits, Andres, Morro, Ainhoa Moliner, Mutso, Margit, Saul, Sirle, Smedberg, Cecilia, Tarve, Liisi, Teppor, Mona, Thaa, Bastian, Varjak, Margus   +13 more
core   +3 more sources

The nonstructural protein NSs of Schmallenberg virus is targeted to the nucleolus and induces nucleolar disorganization [PDF]

, 2016
Schmallenberg virus (SBV) was discovered in Germany in late 2011 and then spread rapidly to many European countries. SBV is an orthobunyavirus that causes abortion and congenital abnormalities in ruminants.
Breard, Emmanuel, Caignard, Grégory, Cochet, Marielle, Coulpier, Muriel, Fablet, Aurore, Gouzil, Julie, Kundlacz, Cindy, Lara, Estelle, Palmarini, Massimo, Sailleau, Corinne, Varela, Mariana, Viarouge, Cyril, Vitour, Damien, Zientara, Stéphan   +13 more
core   +3 more sources

Genetic analysis of porcine productive and respiratory syndrome virus between 2013 and 2014 in Southern parts of China: identification of several novel strains with amino acid deletions or insertions in nsp2

BMC Veterinary Research, 2019
Background Porcine respiratory and reproductive syndrome virus (PRRSV) is one of the most economically significant pathogens in the Chinese swine industry. ORF5 and nsp2 are highly variable regions of the PRRSV genome.
Shaofeng Hong, Ying Wei, Siyuan Lin, Jiabing Huang, Wei He, Jing Yao, Ying Chen, Ouyang Kang, Weijian Huang, Zuzhang Wei   +9 more
doaj   +1 more source

Full Genomic Analysis of New Variants of Porcine Reproductive and Respiratory Syndrome Virus Revealed Multiple Recombination Events Between Different Lineages and Sublineages

Frontiers in Veterinary Science, 2020
Porcine reproductive and respiratory syndrome virus (PRRSV) has had a devastating impact on the pig industry in China, and monitoring its genetic diversity is important for epidemiological surveillance and understanding its evolution.
Jinglong Wang, Siyuan Lin, Dongqun Quan, Hao Wang, Jiabin Huang, Yuxu Wang, Tongwei Ren, Kang Ouyang, Ying Chen, Weijian Huang, Tingrong Luo, Zuzhang Wei   +11 more
doaj   +1 more source

The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex

iScience, 2022
Summary: There is an urgent need for a molecular understanding of how SARS-CoV-2 influences the machineries of the host cell. Herein, we focused our attention on the capacity of the SARS-CoV-2 protein NSP2 to bind the human 4EHP-GIGYF2 complex, a key ...
Limei Zou, Clara Moch, Marc Graille, Clément Chapat   +3 more
doaj   +1 more source

Structural and Functional Studies of Chikungunya Virus nsP2

Proceedings, 2020
Chikungunya virus (CHIKV) is transmitted to humans through mosquitoes and causes Chikungunya fever. Nonstructural protein 2 (nsP2) contains an N-terminal RNA helicase with both nucleotide triphosphatase and RNA triphosphatase activities, and a C-terminal
Yee Song Law, Yaw Bia Tan, Orion Shih, Age Utt, Jie Zheng, Sainan Wang, Ming Wei Chen, Patrick R. Griffin, U-Ser Jeng, Andres Merits, Dahai Luo   +10 more
doaj   +1 more source

Genetic Variability and Recombination of the NSP2 Gene of PRRSV-2 Strains in China from 1996 to 2021

Veterinary Sciences, 2023
Porcine reproductive and respiratory syndrome (PRRS) is one of the most serious infectious diseases that detrimentally affects the pig industry worldwide. The disease, which is typically difficult to control, is an immunosuppressive disease caused by the
Hang Zhang, Qin Luo, Yajie Zheng, Huiyang Sha, Gan Li, Weili Kong, Liangzong Huang, Mengmeng Zhao   +7 more
doaj   +1 more source

2-(3,5-Dimethylbenzene)-1-ferrocenylmethyl-1H-1,3-benzimidazole [PDF]

, 2007
In the title molecule, [Fe(C5H5)(C21H19N2)], the five-membered imidazole ring forms dihedral angles of 88.61 (8) and 42.15 (6)° with the substituted cyclopentadienyl and dimethyl-substituted benzene rings, respectively. In the crystal structure, there is
Gallagher, John F., Hanlon, Keith, Howarth, Joshua   +2 more
core   +1 more source

SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions

Virology Journal, 2023
When viruses like SARS-CoV-2 infect cells, they reprogram the repertoire of cellular and viral transcripts that are being translated to optimize their strategy of replication, often targeting host translation initiation factors, particularly eIF4F ...
Nadejda Korneeva, Md Imtiaz Khalil, Ishita Ghosh, Ruping Fan, Thomas Arnold, Arrigo De Benedetti   +5 more
doaj   +1 more source

GETV nsP2 plays a critical role in the interferon antagonism and viral pathogenesis

Cell Communication and Signaling, 2023
Getah virus (GETV) was becoming more serious and posing a potential threat to animal safety and public health. Currently, there is limited comprehension regarding the pathogenesis and immune evasion mechanisms employed by GETV.
Chunxiao Mou, Hui Meng, Kaichuang Shi, Yanmei Huang, Meiqi Liu, Zhenhai Chen   +5 more
doaj   +1 more source