Results 31 to 40 of about 7,712 (169)

GETV nsP2 plays a critical role in the interferon antagonism and viral pathogenesis

Cell Communication and Signaling, 2023
Getah virus (GETV) was becoming more serious and posing a potential threat to animal safety and public health. Currently, there is limited comprehension regarding the pathogenesis and immune evasion mechanisms employed by GETV.
Chunxiao Mou, Hui Meng, Kaichuang Shi, Yanmei Huang, Meiqi Liu, Zhenhai Chen   +5 more
doaj   +1 more source

SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions

Virology Journal, 2023
When viruses like SARS-CoV-2 infect cells, they reprogram the repertoire of cellular and viral transcripts that are being translated to optimize their strategy of replication, often targeting host translation initiation factors, particularly eIF4F ...
Nadejda Korneeva, Md Imtiaz Khalil, Ishita Ghosh, Ruping Fan, Thomas Arnold, Arrigo De Benedetti   +5 more
doaj   +1 more source

Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation

Virology Journal, 2012
Background Nuclear factor-kappaB (NF-κB) is an inducible transcription factor that plays a key role in inflammation and immune responses, as well as in the regulation of cell proliferation and survival.
Fang Ying, Fang Liurong, Wang Yang, Lei Yingying, Luo Rui, Wang Dang, Chen Huanchun, Xiao Shaobo   +7 more
doaj   +1 more source

Sindbis Virus nsP2 Endopeptidase

, 2013
© 2013 Elsevier Ltd. Available online 9 November 2012.
Strauss, Ellen G., Strauss, James H.
openaire   +2 more sources

TRIM4-mediated ubiquitination of NSP2 restricts porcine reproductive and respiratory syndrome virus proliferation

BMC Veterinary Research, 2022
Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious and virulent infectious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV), which has substantial economic losses in the pig industry worldwide ...
Mengmeng Zhao, Huiyang Sha, Hang Zhang, Ruining Wang   +3 more
doaj   +1 more source

Interleukin-2 enhancer binding factor 2 interacts with the nsp9 or nsp2 of porcine reproductive and respiratory syndrome virus and exerts negatively regulatory effect on the viral replication

Virology Journal, 2017
Background Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive failures in sows and respiratory diseases in growing pigs, resulting in huge economic loss for the pig production worldwide. The nonstructural protein 9 (nsp9) and
Xuexia Wen, Ting Bian, Zhibang Zhang, Lei Zhou, Xinna Ge, Jun Han, Xin Guo, Hanchun Yang, Kangzhen Yu   +8 more
doaj   +1 more source

Nonstructural Protein 2 Is Critical to Infection Efficiency of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus on PAMs and Influence Virulence In Vivo

Viruses, 2022
Porcine reproductive and respiratory syndrome (PRRS) is an important viral disease, causing significant economic losses to the swine industry worldwide. Atypical cases caused by highly pathogenic PRRS virus (HP-PRRSV) emerged in 2006 in China.
Jiazeng Chen, Lingxue Yu, Yanjun Zhou, Shen Yang, Yun Bai, Qian Wang, Jinmei Peng, Tongqing An, Fei Gao, Liwei Li, Chao Ye, Changlong Liu, Guangzhi Tong, Xuehui Cai, Zhijun Tian, Yifeng Jiang   +15 more
doaj   +1 more source

Nodulation Signaling in Legumes Depends on an NSP1-NSP2 Complex [PDF]

The Plant Cell, 2009
The development of nitrogen-fixing root nodules in legumes follows a complex chain of events that is initiated when the rhizobial symbiont perceives certain legume-derived flavonoids and thereby recognizes a potential host plant.
openaire   +2 more sources

The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling.

PLoS Pathogens, 2023
Chikungunya virus (CHIKV) is a reemerging alphavirus. Since 2005, it has infected millions of people during outbreaks in Africa, Asia, and South/Central America.
Emmely E Treffers, Ali Tas, Florine E M Scholte, Arnoud H de Ru, Eric J Snijder, Peter A van Veelen, Martijn J van Hemert   +6 more
doaj   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source