Results 31 to 40 of about 12,594 (172)

A novel mechanism underlying the innate immune response induction upon viral-dependent replication of host cell mRNA: A mistake of +sRNA viruses' replicases [PDF]

, 2017
Viruses are lifeless particles designed for setting virus-host interactome assuring a new generation of virions for dissemination. This interactome generates a pressure on host organisms evolving mechanisms to neutralize viral infection, which places the
Colombo, Maria Isabel, Delgui, Laura Ruth   +1 more
core   +2 more sources

Porcine reproductive and respiratory syndrome virus nonstructural protein 2 contributes to NF-κB activation

Virology Journal, 2012
Background Nuclear factor-kappaB (NF-κB) is an inducible transcription factor that plays a key role in inflammation and immune responses, as well as in the regulation of cell proliferation and survival.
Fang Ying, Fang Liurong, Wang Yang, Lei Yingying, Luo Rui, Wang Dang, Chen Huanchun, Xiao Shaobo   +7 more
doaj   +1 more source

Nonstructural Protein 2 Is Critical to Infection Efficiency of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus on PAMs and Influence Virulence In Vivo

Viruses, 2022
Porcine reproductive and respiratory syndrome (PRRS) is an important viral disease, causing significant economic losses to the swine industry worldwide. Atypical cases caused by highly pathogenic PRRS virus (HP-PRRSV) emerged in 2006 in China.
Jiazeng Chen, Lingxue Yu, Yanjun Zhou, Shen Yang, Yun Bai, Qian Wang, Jinmei Peng, Tongqing An, Fei Gao, Liwei Li, Chao Ye, Changlong Liu, Guangzhi Tong, Xuehui Cai, Zhijun Tian, Yifeng Jiang   +15 more
doaj   +1 more source

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. [PDF]

, 2020
An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.
Cheng, Genhong, Ding, Xiao, Huang, Baoying, Jiang, Taijiao, Meng, Jing, Niu, Peihua, Peng, Yousong, Quan, Lijun, Sheng, Jie, Tan, Wenjie, Wang, Jiangyuan, Wang, Xianyue, Wu, Aiping, Xia, Zanxian, Zhang, Zheng, Zhu, Zhaozhong   +15 more
core  

Stability of local secondary structure determines selectivity of viral RNA chaperones [PDF]

, 2018
To maintain genome integrity, segmented double-stranded RNA viruses of the Reoviridae family must accurately select and package a complete set of up to a dozen distinct genomic RNAs. It is thought that the high fidelity segmented genome assembly involves
Barth, A, Borodavka, A, Bravo, JPK, Calabrese, AN, Cockburn, JJB, Lamb, DC, Mojzes, P, Tuma, R   +7 more
core   +1 more source

Interleukin-2 enhancer binding factor 2 interacts with the nsp9 or nsp2 of porcine reproductive and respiratory syndrome virus and exerts negatively regulatory effect on the viral replication

Virology Journal, 2017
Background Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive failures in sows and respiratory diseases in growing pigs, resulting in huge economic loss for the pig production worldwide. The nonstructural protein 9 (nsp9) and
Xuexia Wen, Ting Bian, Zhibang Zhang, Lei Zhou, Xinna Ge, Jun Han, Xin Guo, Hanchun Yang, Kangzhen Yu   +8 more
doaj   +1 more source

TRIM4-mediated ubiquitination of NSP2 restricts porcine reproductive and respiratory syndrome virus proliferation

BMC Veterinary Research, 2022
Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious and virulent infectious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV), which has substantial economic losses in the pig industry worldwide ...
Mengmeng Zhao, Huiyang Sha, Hang Zhang, Ruining Wang   +3 more
doaj   +1 more source

The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling.

PLoS Pathogens, 2023
Chikungunya virus (CHIKV) is a reemerging alphavirus. Since 2005, it has infected millions of people during outbreaks in Africa, Asia, and South/Central America.
Emmely E Treffers, Ali Tas, Florine E M Scholte, Arnoud H de Ru, Eric J Snijder, Peter A van Veelen, Martijn J van Hemert   +6 more
doaj   +1 more source

Nonstructural proteins nsp2TF and nsp2N of porcine reproductive and respiratory syndrome virus (PRRSV) play important roles in suppressing host innate immune responses. [PDF]

, 2018
Recently, we identified a unique -2/-1 ribosomal frameshift mechanism in PRRSV, which yields two truncated forms of nonstructural protein (nsp) 2 variants, nsp2TF and nsp2N.
Carrillo, C, Fang, Y, Firth, AE, Jaing, Crystal J, Li, Y, Naraghi-Arani, P, Renukaradhya, GJ, Shang, P, Shyu, D, Snijder, EJ   +9 more
core   +1 more source

Transitive permutation groups of prime-squared degree [PDF]

, 2009
We explicitly determine all of the transitive groups of degree p-squared, p a prime, whose Sylow p-subgroup is not the wreath product of two cyclic groups of order p.
Dobson, Edward, Witte, Dave
core   +2 more sources