Results 11 to 20 of about 12,594 (172)

A quantitative high-throughput screening pipeline to identify small molecule inhibitors of Chikungunya nsP2 protease [PDF]

Scientific Reports
Chikungunya virus (CHIKV) is a mosquito-borne RNA virus that has emerged as one of the most important global arboviral threats in the last decade. Although the first CHIKV vaccine has recently been FDA approved for use in healthy adults at increased risk,
Shuaizhang Li, Xin Hu, Yong-Mo Ahn, Angelica Medina, Lin Ye, Audrey Heffner, Simon Messing, John-Paul Denson, Dominic Esposito, Emily M. Lee, Natalia J. Martinez   +10 more
doaj   +2 more sources

Genetic and Respiratory Pathogenic Comparison of Two PRRSV-2 Isolates Classified as Lineage Korean A and B. [PDF]

Transbound Emerg Dis
Porcine reproductive and respiratory syndrome virus (PRRSV) continues to cause substantial economic losses worldwide, and certain lineages circulate in specific countries. Lineage Korean A (LKA), B (LKB), and C (LKC) have been reported exclusively in Korea. However, studies on LKA and LKB have been limited to strains isolated before 2015. In this study,
Na H, Chae C.
europepmc   +2 more sources

NOVEL MUTATIONS IN THE NON-STRUCTURE PROTEIN 2 OF SARS-CoV-2

Mediterranean Journal of Hematology and Infectious Diseases, 2023
Background: Mutation in the genome of SARS-CoV-2 may play a role in immune evasion, pathogenicity and speed of its transmission. Our investigation aimed to evaluate the mutations that exist in the nsp2.
Mohsen Nakhaei, Zohreh-Al-Sadat Ghoreshi, Mohammad Rezaei Zadeh Rukerd, Hedyeh Askarpour, Nasir   +4 more
doaj   +1 more source

Amino Acid Polymorphisms in the VHIID Conserved Motif of Nodulation Signaling Pathways 2 Distinctly Modulate Symbiotic Signaling and Nodule Morphogenesis in Medicago truncatula

Frontiers in Plant Science, 2021
Legumes establish an endosymbiotic association with nitrogen-fixing soil bacteria. Following the mutual recognition of the symbiotic partner, the infection process is controlled by the induction of the signaling pathway and subsequent activation of ...
Szilárd Kovacs, Lili Fodor, Agota Domonkos, Ferhan Ayaydin, Ferhan Ayaydin, Krisztián Laczi, Krisztián Laczi, Gábor Rákhely, Gábor Rákhely, Péter Kalo, Péter Kalo   +10 more
doaj   +1 more source

Nitrile-Specific Protein NSP2 and Its Interacting Protein MPK3 Synergistically Regulate Plant Disease Resistance in Arabidopsis

Plants, 2023
Glucosinolates and their degradation products have a wide range of actions and are important components of plant defense. NSP2 (nitrile-specific protein 2) is a key regulator in the breakdown process of glucosinolates.
Tingting Zhai, Jun Teng, Xintong Fan, Shaowei Yu, Chen Wang, Xingqi Guo, Wei Yang, Shuxin Zhang   +7 more
doaj   +1 more source

The tail domain of PRRSV NSP2 plays a key role in aggrephagy by interacting with 14-3-3ε

Veterinary Research, 2020
Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) is one of the most severe swine diseases that affects almost all swine-breeding countries. Nonstructural protein 2 (NSP2) is one of the most important viral proteins in the
Shengliang Cao, Jiaqi Liu, Guofei Ding, Qingyuan Shao, Bin Wang, Yingchao Li, Jian Feng, Yuzhong Zhao, Sidang Liu, Yihong Xiao   +9 more
doaj   +1 more source

Emerging connections between small RNAs and phytohormones [PDF]

, 2020
Small RNAs (sRNAs), mainly including miRNAs and siRNAs, are ubiquitous in eukaryotes. sRNAs mostly negatively regulate gene expression via (post-)transcriptional gene silencing through DNA methylation, mRNA cleavage, or translation inhibition.
Dubois, Marieke, Gonzalez Sanchez, Nathalie, Inzé, Dirk, Li, Ting   +3 more
core   +2 more sources

Potential Alphavirus Inhibitors From Phytocompounds – Molecular Docking and Dynamics Based Approach

Innovative Biosystems and Bioengineering, 2023
Background. Alphaviral diseases are an economic burden all over the world due to their chronicity and distribution worldwide. The glycoproteins E1 and E2 are important for binding to the surface of the host cell by interacting with the receptors and non ...
Maneesha Sharma, Anu Bansal, Shikha Suman, Neeta Raj Sharma   +3 more
doaj   +1 more source

Interactome profile of the host cellular proteins and the nonstructural protein 2 of porcine reproductive and respiratory syndrome virus. [PDF]

PLoS ONE, 2014
The nonstructural protein 2 (NSP2) is considered to be one of crucial viral proteins in the replication and pathogenesis of porcine reproductive and respiratory syndrome virus (PRRSV).
Li Wang, Lei Zhou, Han Zhang, Yan Li, Xinna Ge, Xin Guo, Kangzhen Yu, Hanchun Yang   +7 more
doaj   +1 more source

In Silico Analysis of SARS-CoV-2 Non-Structural Proteins Reveals an Interaction with the Host’s Heat Shock Proteins That May Contribute to Viral Replications and Development

Current Issues in Molecular Biology, 2023
The non-structural protein 2 (NSP2) is an RNA-binding protein involved in coronavirus genome replication, and it often decreases human immune response to promote viral invasion and development.
Mthembu Yamkela, Zingisa Sitobo, Xolani H. Makhoba   +2 more
doaj   +1 more source