Results 1 to 10 of about 72 (66)

Coordination of Zika Virus Infection and Viroplasm Organization by Microtubules and Microtubule-Organizing Centers

Cells, 2021
Zika virus (ZIKV) became a global health concern in 2016 due to its links to congenital microcephaly and other birth defects. Flaviviruses, including ZIKV, reorganize the endoplasmic reticulum (ER) to form a viroplasm, a compartment where virus particles
Timothy L Megraw, Li Sun, David Meckes
exaly   +3 more sources

A Fijivirus Major Viroplasm Protein Shows RNA-Stimulated ATPase Activity by Adopting Pentameric and Hexameric Assemblies of Dimers

MBio, 2023
Fijiviruses replicate and package their genomes within viroplasms in a process involving RNA-RNA and RNA-protein interactions. Here, we demonstrate that the 24 C-terminal residues (C-arm) of the P9-1 major viroplasm protein of the mal de Río Cuarto virus
Rocio Arranz, Cristian Huck-Iriart, Fernando Goldbaum   +2 more
exaly   +3 more sources

Comparative analysis of NSP5/VP2-induced viroplasm-like structures in rotavirus species A to J

Journal of Virology
Rotavirus (RV) is classified into nine species, A–D and F–J, with RV species A (RVA) being the most extensively studied. While RVA infects infants and young animals, non-RVA species infect adult humans, various mammals, and birds.
Cornel Fraefel, Kurt Tobler, Catherine Eichwald   +2 more
exaly   +3 more sources

Dengue, Yellow Fever, Zika and Chikungunya epidemic arboviruses in Brazil: ultrastructural aspects [PDF]

Memorias do Instituto Oswaldo Cruz, 2021
BACKGROUND The impact of arbovirus cocirculation in Brazil is unknown. Dengue virus (DENV) reinfection may result in more intense viraemia or immunopathology, leading to more severe disease.
Debora Ferreira Barreto-Vieira, Dinair Couto-Lima, Fernanda Cunha Jácome, Gabriela Cardoso Caldas, Ortrud Monika Barth   +4 more
doaj   +1 more source

Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection

eLife, 2022
Liquid-liquid phase separation (LLPS) plays important roles in forming cellular membraneless organelles. However, how host factors regulate LLPS of viral proteins during negative-sense RNA (NSR) virus infection is largely unknown.
Xiao-Dong Fang, Qiang Gao, Ying Zang, Ji-Hui Qiao, Dong-Min Gao, Wen-Ya Xu, Ying Wang, Dawei Li, Xian-Bing Wang   +8 more
doaj   +1 more source

Rotavirus-Induced Lipid Droplet Biogenesis Is Critical for Virus Replication

Frontiers in Physiology, 2022
A variety of pathogens, including viruses, bacteria and parasites, target cellular lipid droplets for their replication. Rotaviruses (RVs) infect the villous epithelium of the small intestine and are a major cause of acute gastroenteritis in infants and ...
Jeanette M. Criglar, Mary K. Estes, Mary K. Estes, Sue E. Crawford   +3 more
doaj   +1 more source

Rotavirus-Mediated Prostaglandin E2 Production in MA104 Cells Promotes Virus Attachment and Internalisation, Resulting in an Increased Viral Load

Frontiers in Physiology, 2022
Rotaviruses are one of the leading causes of severe dehydrating diarrhoea in infants and children under the age of five. Despite the introduction of vaccines, disease burden remains high in sub-Saharan Africa, with no known anti-viral treatments ...
Willem J. Sander, Gabré Kemp, Arnold Hugo, Carolina H. Pohl, Hester G. O’Neill   +4 more
doaj   +1 more source

Viroplasms: Assembly and Functions of Rotavirus Replication Factories

Viruses, 2021
Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers of viroplasm formation ...
Guido Papa, Alexander Borodavka, Ulrich Desselberger   +2 more
doaj   +1 more source

Development of leafhopper cell culture to trace the early infection process of a nucleorhabdovirus, rice yellow stunt virus, in insect vector cells

Virology Journal, 2018
Background In China, the rice pathogen Rice yellow stunt virus (RYSV), a member of the genus Nucleorhabdovirus in the family Rhabdoviridae, was a severe threat to rice production during the1960s and1970s.
Haitao Wang, Juan Wang, Yunjie Xie, Zhijun Fu, Taiyun Wei, Xiao-Feng Zhang   +5 more
doaj   +1 more source

Cytoplasmic factories, virus assembly, and DNA replication kinetics collectively constrain the formation of poxvirus recombinants.

PLoS ONE, 2020
Poxviruses replicate in cytoplasmic structures called factories and each factory begins as a single infecting particle. Sixty-years ago Cairns predicted that this might have effects on vaccinia virus (VACV) recombination because the factories would have ...
Quinten Kieser, Ryan S Noyce, Mira Shenouda, Y-C James Lin, David H Evans   +4 more
doaj   +1 more source