Coordination of Zika Virus Infection and Viroplasm Organization by Microtubules and Microtubule-Organizing Centers [PDF]
Cells, 2021 Zika virus (ZIKV) became a global health concern in 2016 due to its links to congenital microcephaly and other birth defects. Flaviviruses, including ZIKV, reorganize the endoplasmic reticulum (ER) to form a viroplasm, a compartment where virus particles
Li Sun, Yichen Cheng, David G Meckes Jr
exaly +4 more sources
Insect I‐Type Lysozymes Function as Antiviral Proteases by Forming Biomolecular Condensates [PDF]
Advanced ScienceLysozymes are well‐known for their ability to cleave bacterial peptidoglycan, but their potential to hydrolyze viral components as a form of antiviral defense remains poorly understood.
Yu Du +5 more
doaj +3 more sources
Rotavirus-Induced Lipid Droplet Biogenesis Is Critical for Virus Replication [PDF]
Frontiers in Physiology, 2022 A variety of pathogens, including viruses, bacteria and parasites, target cellular lipid droplets for their replication. Rotaviruses (RVs) infect the villous epithelium of the small intestine and are a major cause of acute gastroenteritis in infants and ...
Jeanette M. Criglar +3 more
doaj +5 more sources
A Fijivirus Major Viroplasm Protein Shows RNA-Stimulated ATPase Activity by Adopting Pentameric and Hexameric Assemblies of Dimers [PDF]
mBio, 2023 Fijiviruses replicate and package their genomes within viroplasms in a process involving RNA-RNA and RNA-protein interactions. Here, we demonstrate that the 24 C-terminal residues (C-arm) of the P9-1 major viroplasm protein of the mal de Río Cuarto virus
Gabriela Llauger +18 more
doaj +2 more sources
Comparative analysis of NSP5/VP2-induced viroplasm-like structures in rotavirus species A to J [PDF]
Journal of VirologyRotavirus (RV) is classified into nine species, A–D and F–J, with RV species A (RVA) being the most extensively studied. While RVA infects infants and young animals, non-RVA species infect adult humans, various mammals, and birds.
Ariana Cosic +5 more
doaj +2 more sources
Rotavirus NSP2: A Master Orchestrator of Early Viral Particle Assembly [PDF]
VirusesRotaviruses (RVs) are 11-segmented, double-stranded (ds) RNA viruses and important causes of acute gastroenteritis in humans and other animal species.
Sarah L. Nichols +3 more
doaj +2 more sources
Sneaking into the viral safe-houses: Implications of host components in regulating integrity and dynamics of rotaviral replication factories [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 The biology of the viral life cycle essentially includes two structural and functional entities—the viral genome and protein machinery constituting the viral arsenal and an array of host cellular components which the virus closely associates with—to ...
Pritam Chandra +4 more
doaj +2 more sources
Type II grass carp reovirus utilizes autophagosomes for viroplasm formation and subclinical persistent infection [PDF]
Journal of VirologyGrass carp reovirus (GCRV) is the most virulent pathogen within the genus Aquareovirus, belonging to the family Spinareoviridae. GCRV is categorized into three genotypes, with type II (GCRV-II) being the predominant strain circulating in China ...
Qian Wang +9 more
doaj +2 more sources
The Role of the Host Cytoskeleton in the Formation and Dynamics of Rotavirus Viroplasms [PDF]
VirusesRotavirus (RV) replicates within viroplasms, membraneless electron-dense globular cytosolic inclusions with liquid–liquid phase properties. In these structures occur the virus transcription, replication, and packaging of the virus genome in newly ...
Janine Vetter +2 more
doaj +2 more sources
The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication [PDF]
mBioRotavirus (RV) replication takes place in the viroplasms, cytosolic inclusions that allow the synthesis of virus genome segments and their encapsidation in the core shell, followed by the addition of the second layer of the virion.
Janine Vetter +11 more
doaj +2 more sources