Rotavirus Spike Protein VP4 Mediates Viroplasm Assembly by Association to Actin Filaments [PDF]
Journal of Virology, 2022 Rotavirus (RV) viroplasms are cytosolic inclusions where both virus genome replication and primary steps of virus progeny assembly take place. A stabilized microtubule cytoskeleton and lipid droplets are required for the viroplasm formation, which ...
Janine Vetter +2 more
exaly +4 more sources
Characterization of viroplasm-like structures by co-expression of NSP5 and NSP2 across rotavirus species A to J [PDF]
Journal of VirologyRotaviruses (RVs) are classified into nine species, A–D and F–J, with species A being the most studied. In rotavirus of species A (RVA), replication occurs in viroplasms, which are cytosolic globular inclusions composed of main building block proteins ...
Cornell Fraefel, Catherine Eichwald
exaly +5 more sources
An insect symbiotic virus promotes the transmission of a phytoarbovirus via inhibiting E3 ubiquitin ligase Sina. [PDF]
PLoS PathogensCo-infection with symbiotic viruses and arboviruses with synergistic effects in insect vectors are common in nature, but the underlying mechanism remains elusive.
Hui Wang +5 more
doaj +2 more sources
Grass Carp Reovirus Induces Formation of Lipid Droplets as Sites for Its Replication and Assembly [PDF]
mBio, 2022 Grass carp is an important commercial fish in China that is plagued by various diseases, especially the hemorrhagic disease induced by grass carp reovirus (GCRV).
Libo He +9 more
doaj +2 more sources
Rotavirus Viroplasm Biogenesis Involves Microtubule-Based Dynein Transport Mediated by an Interaction between NSP2 and Dynein Intermediate Chain [PDF]
Journal of Virology, 2021 Li Feng, Jin Tian, Li Feng
exaly +2 more sources
Dengue, Yellow Fever, Zika and Chikungunya epidemic arboviruses in Brazil: ultrastructural aspects [PDF]
Memorias do Instituto Oswaldo Cruz, 2021 BACKGROUND The impact of arbovirus cocirculation in Brazil is unknown. Dengue virus (DENV) reinfection may result in more intense viraemia or immunopathology, leading to more severe disease.
Debora Ferreira Barreto-Vieira +4 more
doaj +1 more source
eLife, 2022 Liquid-liquid phase separation (LLPS) plays important roles in forming cellular membraneless organelles. However, how host factors regulate LLPS of viral proteins during negative-sense RNA (NSR) virus infection is largely unknown.
Xiao-Dong Fang +8 more
doaj +1 more source
Isolation and characterization of a double stranded DNA mgavirus infecting the toxin-producing haptophyte Prymnesium parvum [PDF]
, 2017 Prymnesium parvum is a toxin-producing haptophyte that causes harmful algal blooms globally, leading to large-scale fish kills that have severe ecological and economic implications.
Ben Wagstaff +6 more
core +6 more sources
Frontiers in Physiology, 2022 Rotaviruses are one of the leading causes of severe dehydrating diarrhoea in infants and children under the age of five. Despite the introduction of vaccines, disease burden remains high in sub-Saharan Africa, with no known anti-viral treatments ...
Willem J. Sander +4 more
doaj +1 more source
Viroplasms: Assembly and Functions of Rotavirus Replication Factories
Viruses, 2021 Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers of viroplasm formation ...
Guido Papa +2 more
doaj +1 more source