Viroplasms: Assembly and Functions of Rotavirus Replication Factories [PDF]
Viruses, 2021 Viroplasms are cytoplasmic, membraneless structures assembled in rotavirus (RV)-infected cells, which are intricately involved in viral replication. Two virus-encoded, non-structural proteins, NSP2 and NSP5, are the main drivers of viroplasm formation ...
Guido Papa +2 more
exaly +21 more sources
The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication [PDF]
MBioRotavirus (RV) replication takes place in the viroplasms, cytosolic inclusions that allow the synthesis of virus genome segments and their encapsidation in the core shell, followed by the addition of the second layer of the virion.
Janine Vetter +2 more
exaly +11 more sources
The Role of the Host Cytoskeleton in the Formation and Dynamics of Rotavirus Viroplasms [PDF]
VirusesRotavirus (RV) replicates within viroplasms, membraneless electron-dense globular cytosolic inclusions with liquid–liquid phase properties. In these structures occur the virus transcription, replication, and packaging of the virus genome in newly ...
Janine Vetter +2 more
exaly +7 more sources
Rotavirus-Induced Lipid Droplet Biogenesis Is Critical for Virus Replication [PDF]
Frontiers in Physiology, 2022 A variety of pathogens, including viruses, bacteria and parasites, target cellular lipid droplets for their replication. Rotaviruses (RVs) infect the villous epithelium of the small intestine and are a major cause of acute gastroenteritis in infants and ...
Jeanette M. Criglar +3 more
doaj +5 more sources
Type II grass carp reovirus utilizes autophagosomes for viroplasm formation and subclinical persistent infection [PDF]
Journal of VirologyGrass carp reovirus (GCRV) is the most virulent pathogen within the genus Aquareovirus, belonging to the family Spinareoviridae. GCRV is categorized into three genotypes, with type II (GCRV-II) being the predominant strain circulating in China ...
Qian Wang +9 more
doaj +4 more sources
Principles of RNA recruitment to viral ribonucleoprotein condensates in a segmented dsRNA virus [PDF]
eLife, 2023 Rotaviruses transcribe 11 distinct RNAs that must be co-packaged prior to their replication to make an infectious virion. During infection, nontranslating rotavirus transcripts accumulate in cytoplasmic protein-RNA granules known as viroplasms that ...
Sebastian Strauss +6 more
doaj +2 more sources
Grass Carp Reovirus Induces Formation of Lipid Droplets as Sites for Its Replication and Assembly [PDF]
mBio, 2022 Grass carp is an important commercial fish in China that is plagued by various diseases, especially the hemorrhagic disease induced by grass carp reovirus (GCRV).
Libo He +9 more
doaj +2 more sources
Sneaking into the viral safe-houses: Implications of host components in regulating integrity and dynamics of rotaviral replication factories [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 The biology of the viral life cycle essentially includes two structural and functional entities—the viral genome and protein machinery constituting the viral arsenal and an array of host cellular components which the virus closely associates with—to ...
Pritam Chandra +4 more
doaj +2 more sources
Comparative analysis of NSP5/VP2-induced viroplasm-like structures in rotavirus species A to J [PDF]
Journal of VirologyRotavirus (RV) is classified into nine species, A–D and F–J, with RV species A (RVA) being the most extensively studied. While RVA infects infants and young animals, non-RVA species infect adult humans, various mammals, and birds.
Ariana Cosic +5 more
doaj +2 more sources
Rotavirus-Mediated Prostaglandin E2 Production in MA104 Cells Promotes Virus Attachment and Internalisation, Resulting in an Increased Viral Load [PDF]
Frontiers in Physiology, 2022 Rotaviruses are one of the leading causes of severe dehydrating diarrhoea in infants and children under the age of five. Despite the introduction of vaccines, disease burden remains high in sub-Saharan Africa, with no known anti-viral treatments ...
Willem J. Sander +4 more
doaj +2 more sources