Results 31 to 40 of about 1,322 (161)

Rotavirus Replication Requires a Functional Proteasome for Effective Assembly of Viroplasms [PDF]

Journal of Virology, 2011
ABSTRACTThe ubiquitin-proteasome system has been shown to play an important role in the replication cycle of different viruses. In this study, we describe a strong impairment of rotavirus replication upon inhibition of proteasomal activity. The effect was evidenced at the level of accumulation of viral proteins, viral RNA, and yield of infective ...
Contin R., Arnoldi F., Mano M., Burrone O. R.   +3 more
openaire   +3 more sources

Identification of a Plant Viral RNA Genome in the Nucleus [PDF]

, 2012
10.1371/journal.pone.0048736PLoS ...
Gao, R., Liu, P., Wong, S.-M.
core   +7 more sources

Three‐dimensional analysis of membrane structures associated with tomato spotted wilt virus infection

Plant, Cell &Environment, Volume 46, Issue 2, Page 650-664, February 2023., 2023
Abstract To study viral infection, the direct structural visualization of the viral life cycle consisting of virus attachment, entry, replication, assembly and transport is essential. Although conventional electron microscopy (EM) has been extremely helpful in the investigation of virus–host cell interactions, three‐dimensional (3D) EM not only ...
Jiansheng Guo, Guan Wang, Li Xie, Xinqiu Wang, Lingchong Feng, Wangbiao Guo, Xiaorong Tao, Bruno M. Humbel, Zhongkai Zhang, Jian Hong   +9 more
wiley   +1 more source

Characterization of viroplasm-like structures by co-expression of NSP5 and NSP2 across rotavirus species A to J. [PDF]

J Virol
Rotaviruses (RVs) are classified into nine species, A–D and F–J, with species A being the most studied. In rotavirus of species A (RVA), replication occurs in viroplasms, which are cytosolic globular inclusions composed of main building block proteins ...
Lee M, Cosic A, Tobler K, Aguilar C, Fraefel C, Eichwald C.   +5 more
europepmc   +3 more sources

Lipid Droplets in Virus Replication. [PDF]

FEBS Lett
Intracellular pathogens rely on host metabolic networks for multiplication. Enveloped viruses need lipids for formation of the viral envelope and positive sense RNA viruses that replicate in membranous inclusions require lipids for formation of the replication compartments.
Herker E.
europepmc   +2 more sources

Monitoring SARS-CoV-2 Dissemination in Wastewater and Virus Isolation in Cell Cultures: An Integrated Approach for Pathogen Detection and Surveillance. [PDF]

J Cell Mol Med
ABSTRACT Our study presents wastewater (WW) monitoring data, focusing on determining the infectivity of SARS‐CoV‐2 in the collected samples. Additionally, a panel of different viruses has been tested in the WW samples. The untreated WW monitoring campaign took place over 1 year in Bucharest, with approximately 300 samples being collected twice a week ...
Radu E, Fertig TE, Dragu LD, Pitică IM, Surleac M, Neagu AI, Pană L, Păiş A, Matei L, Antone-Iordache IL, Marta DS, Peteu VE, Niţă-Lazăr M, Stoica C, Popescu C, Sultana CM, Botezatu A, Iancu IV, Chivu-Economescu M, Banică L, Petre AS, Paraschiv S, Gherghiceanu M, Ruta SM, Kreuzinger N, Diaconu CC, Bleotu C.   +26 more
europepmc   +2 more sources

A little less aggregation a little more replication: Viral manipulation of stress granules

WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023
Viruses depend entirely on host machinery and therefore aim to conquer the host and defeat its defenses to co‐opt its resources for its own replication. Improved understanding of how viruses counteract host immune responses such as stress granule assembly, detailed here, will inform future antiviral therapeutic strategies.
Matthew J. Brownsword, Nicolas Locker
wiley   +1 more source

Sonchus Yellow Net Rhabdovirus Nuclear Viroplasms Contain Polymerase-Associated Proteins [PDF]

Journal of Virology, 1998
ABSTRACTWe have initiated a study of the cytopathology of nucleorhabdoviruses by analyzing the subcellular localization of sonchus yellow net virus (SYNV) genomic and antigenomic RNAs and the encoded polymerase proteins. In situ hybridizations demonstrated that the minus-strand genomic RNA sequences are restricted to the nuclei of infected cells, while
C R, Martins, J A, Johnson, D M, Lawrence, T J, Choi, A M, Pisi, S L, Tobin, D, Lapidus, J D, Wagner, S, Ruzin, K, McDonald, A O, Jackson   +10 more
openaire   +2 more sources

Rotavirus infects human biliary epithelial cells and stimulates secretion of cytokines IL-6 and IL-8 via MAPK pathway [PDF]

, 2015
Biliary atresia (BA) is an infantile inflammatory cholangiopathy of unknown etiology although epidemiologic studies and animal models utilizing rotavirus (RV) have suggested a role for viral infection.
Anders, Robert Albert, Clemente, Maria Grazia, Patton, John T., Schwarz, Kathleen, Yolken, Robert H.   +4 more
core   +8 more sources

Evidence that avian reovirus σNS is an RNA chaperone: implications for genome segment assortment. [PDF]

, 2015
Reoviruses are important human, animal and plant pathogens having 10-12 segments of double-stranded genomic RNA. The mechanisms controlling the assortment and packaging of genomic segments in these viruses, remain poorly understood.
Ault, J, Borodavka, A, Stockley, PG, Tuma, R   +3 more
core   +1 more source