Results 21 to 30 of about 7,665 (202)

A structural roadmap for the formation of the coronavirus nsp3/nsp4 double membrane vesicle pore and its implications for polyprotein processing and replication/transcription. [PDF]

J Virol
Coronavirus replication is understood to occur within double membrane vesicles (DMVs) that arise during viral infection. Prior work has determined that these DMVs have characteristic pores formed from the non-structural viral proteins nsp3 and nsp4 ...
Perry JK, Itskanov S, Bilello JP, Lansdon EB.   +3 more
europepmc   +2 more sources

Comparative analysis of NSP5/VP2-induced viroplasm-like structures in rotavirus species A to J. [PDF]

J Virol
Rotavirus (RV) is classified into nine species, A–D and F–J, with RV species A (RVA) being the most extensively studied. While RVA infects infants and young animals, non-RVA species infect adult humans, various mammals, and birds.
Cosic A, Lee M, Tobler K, Aguilar C, Fraefel C, Eichwald C.   +5 more
europepmc   +2 more sources

The P132H mutation of SARS-CoV-2 NSP5 relieves its inhibition on interferon-β activation via blocking MAVS degradation. [PDF]

Cell Mol Life Sci
The prevalence of the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important transition in the epidemic of coronavirus disease 2019 (COVID-19).
Zhang Y, Wang TY, Yan H, Guo Z, Lian Z, Yao H, Yuan S, Ge XY, Qiu Y.   +8 more
europepmc   +2 more sources

Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activity. [PDF]

J Virol
Porcine reproductive and respiratory syndrome virus (PRRSV) infections often trigger oxidative stress and cytokine storms, resulting in significant tissue damage that causes fatalities in piglets and reproductive issues in sows.
Wang F, Amona FM, Pang Y, Zhang Q, Liang Y, Chen X, Ke Y, Chen J, Song C, Wang Y, Li Z, Zhang C, Fang X, Chen X.   +13 more
europepmc   +2 more sources

Amino acid T25 in the substrate-binding domain of SARS-CoV-2 nsp5 is involved in viral replication in the mouse lung. [PDF]

PLoS One
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 5 (nsp5) is a cysteine protease involved in viral replication and suppression of the host immune system.
Sugiura Y, Shimizu K, Takahashi T, Ueno S, Tanigou H, Amarbayasgalan S, Kamitani W.   +6 more
europepmc   +2 more sources

Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation. [PDF]

Vet Res
Porcine reproductive and respiratory syndrome virus (PRRSV) inhibits the host innate immune response to promote its replication. The ubiquitin–proteasome system (UPS) and ISGylation both play roles in modulating host innate immunity. Within this process,
Zhu Z, Chen L, Zhang M, Lin Q, Yan Y, Wang W, Wen W, Zhang Z, Li X.   +8 more
europepmc   +2 more sources

A Gaussia luciferase reporter assay for the evaluation of coronavirus Nsp5/3CLpro activity

Scientific Reports
Human coronaviruses (hCoVs) infect millions of people every year. Among these, MERS, SARS-CoV-1, and SARS-CoV-2 caused significant morbidity and mortality and their emergence highlights the risk of possible future coronavirus outbreaks.
Asimenia Vlachou, Rayhane Nchioua, Kerstin Regensburger, Frank Kirchhoff, Dorota Kmiec   +4 more
doaj   +3 more sources

Diagnostic Study on NSP5 of Human Rotavirus in Najaf Governorate

Kufa Journal for Nursing Sciences, 2015
Objectives: Human rotavirus is the common cause of diarrhea-related illness and death among infants and young children, can lead to severe and sometimes lethal dehydration .
Saif Jabbar Yasir
doaj   +2 more sources

The NSP5, ORF6 and NSP13 of SARS-CoV-2 Cooperate to Modulate Inflammatory Cell Death Activation. [PDF]

Adv Sci (Weinh)
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Wang H, Liang M, Zhang J, Tong H, Zhang F, Liu Y, Wang P, Chang M, Han F, Liu S, Lin Y, Song W, Karki R, Wang P, Chen H, Liu Y, Zheng M.   +16 more
europepmc   +2 more sources

Transient SARS-CoV-2 RNA-Dependent RNA Polymerase Mutations after Remdesivir Treatment for Chronic COVID-19 in Two Transplant Recipients: Case Report and Intra-Host Viral Genomic Investigation

Microorganisms, 2023
Remdesivir is the first FDA-approved drug for treating severe SARS-CoV-2 infection and targets RNA-dependent RNA polymerase (RdRp) that is required for viral replication.
Shangxin Yang, Ashrit Multani, Jacob M. Garrigues, Michael S. Oh, Peera Hemarajata, Taylor Burleson, Nicole M. Green, Caspian Oliai, Pryce T. Gaynor, Omer E. Beaird, Drew J. Winston, Christopher S. Seet, Joanna M. Schaenman   +12 more
doaj   +1 more source