Results 31 to 40 of about 7,665 (202)
Analysis of Rotavirus Nonstructural Protein NSP5 Phosphorylation [PDF]
Journal of Virology, 1998 ABSTRACT The rotavirus nonstructural phosphoprotein NSP5 is encoded by a gene in RNA segment 11. Immunofluorescence analysis of fixed cells showed that NSP5 polypeptides remained confined to viroplasms even at a late stage when provirions migrated from these structures.
J, Blackhall +3 more
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Frontiers in Immunology, 2023 Swine acute diarrhoea syndrome coronavirus (SADS-CoV), which is a recently discovered enteric coronavirus, is the major aetiological agent that causes severe clinical diarrhoea and intestinal pathological damage in pigs, and it has caused significant ...
Hai-xin Huang +12 more
doaj +1 more source
In vitro and in vivo characterization of SARS-CoV-2 resistance to ensitrelvir
Nature Communications, 2023 Ensitrelvir, an oral antiviral agent that targets a SARS-CoV-2 main protease (3CLpro or Nsp5), is clinically useful against SARS-CoV-2 including its omicron variants.
Maki Kiso +8 more
doaj +1 more source
Biomolecules, 2022 Gold compounds have a long tradition in medicine and offer many opportunities for new therapeutic applications. Herein, we evaluated the lead compound Auranofin and five related gold(I) complexes as possible inhibitors of SARS-CoV-2 Main Protease (SARS ...
Lara Massai +7 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Non-structural protein 5 (Nsp5) is a cysteine protease that plays a key role in SARS-CoV-2 replication, suppressing host protein synthesis and promoting immune evasion.
Elisa Bianconi +11 more
doaj +1 more source
Serine protein kinase activity associated with rotavirus phosphoprotein NSP5 [PDF]
Journal of Virology, 1997 The rotavirus nonstructural protein NSP5, a product of the smallest genomic RNA segment, is a phosphoprotein containing O-linked N-acetylglucosamine. We investigated the phosphorylation of NSP5 in monkey MA104 cells infected with simian rotavirus SA11.
J, Blackhall +3 more
openaire +2 more sources
Frontiers in Immunology, 2023 Porcine reproductive and respiratory syndrome virus (PRRSV) remains a leading cause of economic loss in pig farming worldwide. Existing commercial vaccines, all based on modified live or inactivated PRRSV, fail to provide effective immunity against the ...
Rory C. F. de Brito +23 more
doaj +1 more source
Rotavirus Nonstructural Protein NSP5 Interacts with Major Core Protein VP2 [PDF]
Journal of Virology, 2003 ABSTRACTRotavirus is a nonenveloped virus with a three-layered capsid. The inner layer, made of VP2, encloses the genomic RNA and two minor proteins, VP1 and VP3, with which it forms the viral core. Core assembly is coupled with RNA viral replication and takes place in definite cellular structures termed viroplasms.
Berois, Mabel +4 more
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Predicted coronavirus Nsp5 protease cleavage sites in the human proteome
BMC Genomic Data, 2022 Abstract Background The coronavirus nonstructural protein 5 (Nsp5) is a cysteine protease required for processing the viral polyprotein and is therefore crucial for viral replication. Nsp5 from several coronaviruses have also been found to cleave host proteins, disrupting molecular pathways ...
Scott, Benjamin M. +4 more
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SARS-CoV-2 Nsp5 Protein Causes Acute Lung Inflammation, A Dynamical Mathematical Model [PDF]
Frontiers in Systems Biology, 2021 In the present work we propose a dynamical mathematical model of the lung cells inflammation process in response to SARS-CoV-2 infection. In this scenario the main protease Nsp5 enhances the inflammatory process, increasing the levels of NF kB, IL-6, Cox2, and PGE2 with respect to a reference state without the virus. In presence of
Díaz, José +2 more
openaire +3 more sources