Association of rotavirus viroplasms with microtubules through NSP2 and NSP5 [PDF]
Memorias do Instituto Oswaldo Cruz, 2006 Rotavirus replication and virus assembly take place in electrodense spherical structures known as viroplasms whose main components are the viral proteins NSP2 and NSP5.
Claudio Cabral-Romero +1 more
doaj +5 more sources
Conserved Rotavirus NSP5 and VP2 Domains Interact and Affect Viroplasm [PDF]
Journal of Virology, 2020 Alternative treatments to combat rotavirus infection are a requirement for susceptible communities where vaccines cannot be applied. This demand is urgent for newborn infants, immunocompromised patients, adults traveling to high-risk regions, and even for the livestock industry.
Kurt Tobler +2 more
exaly +6 more sources
PRRSV NSP5 orchestrates dual immune disruption by targeting NLRP3 and STING [PDF]
Veterinary ResearchInflammasomes and interferons are two critical defense mechanisms of innate immunity, and their imbalance is a key strategy employed by viruses to evade host immune surveillance.
Xiangyu Huang +8 more
doaj +4 more sources
SADS-CoV nsp5 Inhibits Interferon Production by Targeting Kinase IKKε [PDF]
MicroorganismsSwine acute diarrhea syndrome coronavirus (SADS-CoV), initially identified in China in February 2017, severely impacts the swine industry by causing lethal watery diarrhea in neonatal piglets. Understanding the molecular mechanism employed by SADS-CoV to
Gaoli She +9 more
doaj +4 more sources
Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2 [PDF]
Journal of Virology, 2017 ABSTRACT Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus. The first outbreak of PDCoV was announced from the United States in 2014, followed by reports in Asia. The nonstructural protein nsp5 is a 3C-like protease of coronavirus, and our previous study showed that PDCoV nsp5 inhibits type I interferon (IFN ...
Dang Wang, Jiyao Chen, Guiqing Peng
exaly +4 more sources
Diagnostic Study on NSP5 of Human Rotavirus in Najaf Governorate [PDF]
Kufa Journal for Nursing Sciences, 2015 Objectives: Human rotavirus is the common cause of diarrhea-related illness and death among infants and young children, can lead to severe and sometimes lethal dehydration .
Saif Jabbar Yasir
doaj +3 more sources
SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS
Frontiers in Immunology, 2021 The COVID-19 is an infectious disease caused by SARS-CoV-2 infection. A large number of clinical studies found high-level expression of pro-inflammatory cytokines in patients infected with SARS-CoV-2, which fuels the rapid development of the disease ...
Weiling Li, Jialu Qiao, Qian Peng
exaly +3 more sources
Rotavirus NSP5 orchestrates recruitment of viroplasmic proteins
Journal of General Virology, 2010 Rotavirus genome replication and the first steps of virus morphogenesis take place in cytoplasmic viral factories, called viroplasms, containing four structural (VP1, VP2, VP3 and VP6) and two non-structural (NSP2 and NSP5) proteins. NSP2 and NSP5 have been shown to be essential for viroplasm formation and, when co-expressed in uninfected cells, to ...
R. Contin +3 more
openaire +4 more sources
Predicted coronavirus Nsp5 protease cleavage sites in the human proteome
BMC Genomic Data, 2022 Abstract Background The coronavirus nonstructural protein 5 (Nsp5) is a cysteine protease required for processing the viral polyprotein and is therefore crucial for viral replication. Nsp5 from several coronaviruses have also been found to cleave host proteins, disrupting molecular pathways ...
Scott, Benjamin M. +4 more
openaire +4 more sources
PDCoV NSP5 cleaves the selective autophagy receptor CCDC50 to disrupt autophagic degradation of the viral envelope protein [PDF]
mBioSelective autophagy is a critical host defense mechanism that eliminates viral components through lysosomal degradation during coronavirus infection. Coronaviruses (CoVs), however, deploy countermeasures that disrupt this process, and several underlying ...
Ke Li +11 more
doaj +2 more sources