Results 11 to 20 of about 7,665 (202)

Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling Pathway

Microbiology Spectrum, 2022
Over the last 2 years, several global virus-host interactome studies have been published with SARS-CoV-2 proteins with the purpose of better understanding how specific viral proteins can subvert or utilize different cellular processes to promote viral ...
GOPAL NAIK NENAVATH, Zsolt Toth
exaly   +5 more sources

SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS [PDF]

Frontiers in Immunology, 2021
The COVID-19 is an infectious disease caused by SARS-CoV-2 infection. A large number of clinical studies found high-level expression of pro-inflammatory cytokines in patients infected with SARS-CoV-2, which fuels the rapid development of the disease ...
Jialu Qiao, Qian Peng, Yuchen Liu
exaly   +5 more sources

SADS-CoV nsp5 Inhibits Interferon Production by Targeting Kinase IKKε. [PDF]

Microorganisms
Swine acute diarrhea syndrome coronavirus (SADS-CoV), initially identified in China in February 2017, severely impacts the swine industry by causing lethal watery diarrhea in neonatal piglets. Understanding the molecular mechanism employed by SADS-CoV to
She G, Zhong C, Pan Y, Chen Z, Li J, Li M, Liu Y, Cao Y, Wei X, Xue C.   +9 more
europepmc   +3 more sources

PRRSV NSP5 orchestrates dual immune disruption by targeting NLRP3 and STING. [PDF]

Vet Res
Inflammasomes and interferons are two critical defense mechanisms of innate immunity, and their imbalance is a key strategy employed by viruses to evade host immune surveillance.
Huang X, Xiang X, Jiang X, Qu W, Zhang Y, Zhao Z, Li M, Wang H, Li X.   +8 more
europepmc   +3 more sources

PDCoV NSP5 cleaves the selective autophagy receptor CCDC50 to disrupt autophagic degradation of the viral envelope protein. [PDF]

mBio
Selective autophagy is a critical host defense mechanism that eliminates viral components through lysosomal degradation during coronavirus infection. Coronaviruses (CoVs), however, deploy countermeasures that disrupt this process, and several underlying ...
Li K, Wei H, Zhao K, Chen D, Sun Y, Zhou P, Jin H, Jongkaewwattana A, Suolang S, Wang D, Zhou H, Luo R.   +11 more
europepmc   +2 more sources

Cleavage of the selective autophagy receptor SQSTM1/p62 by the SARS-CoV-2 main protease NSP5 prevents the autophagic degradation of viral membrane proteins

Molecular Biomedicine, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the coronavirus disease 2019 (COVID-19) global pandemic. Omicron, a new variant of SARS-CoV-2, has the characteristics of strong transmission and pathogenicity, short incubation ...
Huihui Li, Kefeng Lu
exaly   +2 more sources

SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules

Signal Transduction and Targeted Therapy, 2022
As a highly pathogenic human coronavirus, SARS-CoV-2 has to counteract an intricate network of antiviral host responses to establish infection and spread.
Yi Zheng, Chengjiang Gao, Pei-Hui Wang
exaly   +2 more sources

Coronaviruses Nsp5 Antagonizes Porcine Gasdermin D-Mediated Pyroptosis by Cleaving Pore-Forming p30 Fragment

MBio, 2022
Coronaviruses (CoVs) are a family of RNA viruses that typically cause respiratory, enteric, and hepatic diseases in animals and humans. Here, we use porcine epidemic diarrhea virus (PEDV) as a model of CoVs to illustrate the reciprocal regulation between
Fushan Shi, Qian Lv, Wei Xu
exaly   +3 more sources

PRRSV evades innate immune cGAS-STING antiviral function via its Nsp5 to deter STING translocation and activation. [PDF]

Virulence
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is an important pathogen that seriously endangers pig breeding, causing significant economic losses to the global swine industry.
Xu Y, Chi C, Xin Q, Yu J, Zhang Y, Zhang P, Zheng W, Jiang S, Zheng W, Chen N, Wu J, Zhu J.   +11 more
europepmc   +2 more sources

The non-structural protein 5 and matrix protein are antigenic targets of T cell immunity to genotype 1 porcine reproductive and respiratory syndrome viruses [PDF]

Frontiers in Immunology, 2016
The porcine reproductive and respiratory syndrome virus (PRRSV) is the cause of one of the most economically important diseases affecting swine worldwide.
Helen eMokhtar, Helen eMokhtar, Miriam ePedrera, Jean-Pierre eFrossard, Lucia eBiffar, Sabine eHammer, Lise eKvisgaard, Lars eLarsen, Graham eStewart, Satyranayrana eSomaravarapu, Falko eSteinbach, Simon Paul Graham   +11 more
doaj   +5 more sources