SADS-CoV nsp5 Inhibits Interferon Production by Targeting Kinase IKKε [PDF]
MicroorganismsSwine acute diarrhea syndrome coronavirus (SADS-CoV), initially identified in China in February 2017, severely impacts the swine industry by causing lethal watery diarrhea in neonatal piglets. Understanding the molecular mechanism employed by SADS-CoV to
Gaoli She +9 more
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Swine acute diarrhoea syndrome coronavirus (SADS-CoV) Nsp5 antagonizes type I interferon signaling by cleaving DCP1A [PDF]
Frontiers in Immunology, 2023 Swine acute diarrhoea syndrome coronavirus (SADS-CoV), which is a recently discovered enteric coronavirus, is the major aetiological agent that causes severe clinical diarrhoea and intestinal pathological damage in pigs, and it has caused significant ...
Hai-xin Huang +12 more
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Coronavirus Nsp5‑mediated dual‑site cleavage of GSDMA modifies its antiviral and proinflammatory functions. [PDF]
PLoS PathogensAlthough Gasdermin A (GSDMA) drives inflammation by inducing pyroptosis, its specific role in antiviral defense remains unclear. Here we identify GSDMA as an immunomodulatory protein activated in response to coronavirus (CoV) infection. Specifically, CoV-
Chenyu Li +16 more
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Cleavage of TOM1 by the SARS-CoV-2 main protease NSP5 prevents autophagic degradation of viral envelope [PDF]
Journal of VirologyAutophagy plays a critical role in viral replication and the regulation of host immune responses. Although the TOM1-TOLLIP complex has been implicated in immune signaling, cargo trafficking, and endocytosis, its role in viral replication has not been ...
Qingxiang Zhang +6 more
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A structural roadmap for the formation of the coronavirus nsp3/nsp4 double membrane vesicle pore and its implications for polyprotein processing and replication/transcription [PDF]
Journal of VirologyCoronavirus replication is understood to occur within double membrane vesicles (DMVs) that arise during viral infection. Prior work has determined that these DMVs have characteristic pores formed from the non-structural viral proteins nsp3 and nsp4 ...
Jason K. Perry +3 more
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The P132H mutation of SARS-CoV-2 NSP5 relieves its inhibition on interferon-β activation via blocking MAVS degradation [PDF]
Cellular and Molecular Life SciencesThe prevalence of the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important transition in the epidemic of coronavirus disease 2019 (COVID-19).
Yuxin Zhang +8 more
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PRRSV evades innate immune cGAS-STING antiviral function via its Nsp5 to deter STING translocation and activation [PDF]
VirulencePorcine Reproductive and Respiratory Syndrome Virus (PRRSV) is an important pathogen that seriously endangers pig breeding, causing significant economic losses to the global swine industry.
Yulin Xu +11 more
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Association of rotavirus viroplasms with microtubules through NSP2 and NSP5 [PDF]
Memorias do Instituto Oswaldo Cruz, 2006 Rotavirus replication and virus assembly take place in electrodense spherical structures known as viroplasms whose main components are the viral proteins NSP2 and NSP5.
Claudio Cabral-Romero +1 more
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Comparative analysis of NSP5/VP2-induced viroplasm-like structures in rotavirus species A to J [PDF]
Journal of VirologyRotavirus (RV) is classified into nine species, A–D and F–J, with RV species A (RVA) being the most extensively studied. While RVA infects infants and young animals, non-RVA species infect adult humans, various mammals, and birds.
Ariana Cosic +5 more
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Porcine reproductive and respiratory syndrome virus NSP5 exploited UBE2L6 to promote viral replication via antagonising host RLRs and ISGylation [PDF]
Veterinary ResearchPorcine reproductive and respiratory syndrome virus (PRRSV) inhibits the host innate immune response to promote its replication. The ubiquitin–proteasome system (UPS) and ISGylation both play roles in modulating host innate immunity. Within this process,
Zhenbang Zhu +8 more
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