Involvement of PRRSV NSP3 and NSP5 in the autophagy process
Virology Journal, 2019 Background Autophagy is an essential process in eukaryotic cells in which autophagosomes form to deliver cellular organelles and long-lived proteins to lysosomes for degradation. Many studies have recently identified the regulatory mechanisms involved in
Wei Zhang +4 more
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Association of rotavirus viroplasms with microtubules through NSP2 and NSP5 [PDF]
Memorias do Instituto Oswaldo Cruz, 2006 Rotavirus replication and virus assembly take place in electrodense spherical structures known as viroplasms whose main components are the viral proteins NSP2 and NSP5.
Claudio Cabral-Romero +1 more
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A Gaussia luciferase reporter assay for the evaluation of coronavirus Nsp5/3CLpro activity
Scientific ReportsHuman coronaviruses (hCoVs) infect millions of people every year. Among these, MERS, SARS-CoV-1, and SARS-CoV-2 caused significant morbidity and mortality and their emergence highlights the risk of possible future coronavirus outbreaks.
Asimenia Vlachou +4 more
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SADS-CoV nsp5 Inhibits Interferon Production by Targeting Kinase IKKε
MicroorganismsSwine acute diarrhea syndrome coronavirus (SADS-CoV), initially identified in China in February 2017, severely impacts the swine industry by causing lethal watery diarrhea in neonatal piglets. Understanding the molecular mechanism employed by SADS-CoV to
Gaoli She +9 more
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Broad antagonism of coronaviruses nsp5 to evade the host antiviral responses by cleaving POLDIP3.
PLoS Pathogens, 2023 Coronaviruses (CoVs) are a family of the largest RNA viruses that typically cause respiratory, enteric, and hepatic diseases in animals and humans, imposing great threats to the public safety and animal health.
Yang Wu +9 more
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Diagnostic Study on NSP5 of Human Rotavirus in Najaf Governorate
Kufa Journal for Nursing Sciences, 2015 Objectives: Human rotavirus is the common cause of diarrhea-related illness and death among infants and young children, can lead to severe and sometimes lethal dehydration .
Saif Jabbar Yasir
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PRRSV NSP5 orchestrates dual immune disruption by targeting NLRP3 and STING
Veterinary ResearchInflammasomes and interferons are two critical defense mechanisms of innate immunity, and their imbalance is a key strategy employed by viruses to evade host immune surveillance.
Xiangyu Huang +8 more
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A Gain-of-Function Cleavage of TonEBP by Coronavirus NSP5 to Suppress IFN-β Expression
CellsHuman coronaviruses (HCoVs) modify host proteins to evade the antiviral defense and sustain viral expansion. Here, we report tonicity-responsive enhancer (TonE) binding protein (TonEBP) as a cellular target of HCoVs.
Hyun Park +8 more
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Analysis of Rotavirus Nonstructural Protein NSP5 Phosphorylation [PDF]
Journal of Virology, 1998 ABSTRACT The rotavirus nonstructural phosphoprotein NSP5 is encoded by a gene in RNA segment 11. Immunofluorescence analysis of fixed cells showed that NSP5 polypeptides remained confined to viroplasms even at a late stage when provirions migrated from these structures.
J, Blackhall +3 more
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Hyperphosphorylation of the Rotavirus NSP5 Protein Is Independent of Serine 67 or NSP2, and the Intrinsic Insolubility of NSP5 Is Regulated by Cellular Phosphatases [PDF]
Journal of Virology, 2006 ABSTRACT The NSP5 protein is required for viroplasm formation during rotavirus infection and is hyperphosphorylated into 32- to 35-kDa isoforms. Earlier studies reported that NSP5 is not hyperphosphorylated without NSP2 coexpression or deleting the NSP5 N terminus and that serine 67 is essential for NSP5 hyperphosphorylation.
Adrish, Sen +2 more
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