Results 1 to 10 of about 492 (91)

Nonstructural protein NS80 is crucial in recruiting viral components to form aquareoviral factories. [PDF]

PLoS ONE, 2013
BACKGROUND: Replication and assembly of vertebrate reoviruses occur in specific intracellular compartments known as viral factories. Recently, NS88 and NS80, the nonstructural proteins from aquareoviruses, have been proposed to share common traits with ...
Fei Ke, Li-Bo He, Qi-Ya Zhang
doaj   +3 more sources

Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins

Membranes, 2022
Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins.
Qingxin Li, Congbao Kang
doaj   +1 more source

Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles

mBio, 2021
The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus replication
Christopher H. Lee, Krishnan Raghunathan, Gwen M. Taylor, Andrea J. French, Raquel Tenorio, Isabel Fernández de Castro, Cristina Risco, John S. L. Parker, Terence S. Dermody   +8 more
doaj   +1 more source

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source

Flavivirus Capsid Proteins Inhibit the Interferon Response

Viruses, 2022
Zika virus (ZIKV) establishes persistent infections in multiple human tissues, a phenomenon that likely plays a role in its ability to cause congenital birth defects and neurological disease. Multiple nonstructural proteins encoded by ZIKV, in particular
Adriana M. Airo, Alberto Felix-Lopez, Valeria Mancinelli, Danyel Evseev, Joaquin Lopez-Orozco, Kathy Shire, Patrick Paszkowski, Lori Frappier, Katharine E. Magor, Tom C. Hobman   +9 more
doaj   +1 more source

Functional studies of the coronavirus nonstructural proteins

STEMedicine, 2020
Coronaviruses, including SARS-CoV, SARS-CoV-2, and MERS-CoV, have caused contagious and fatal respiratory diseases in humans worldwide. Notably, the coronavirus disease 19 (COVID-19) caused by SARS-CoV-2 spread rapidly in early 2020 and became a global ...
Yanglin Qiu, Kai Xu
doaj   +1 more source

Structural Motifs and Spatial Structures of Helicase (NS3) and RNA-dependent RNA-polymerase (NS5) of a Flavi-like Kindia tick virus (unclassified Flaviviridae)

Вопросы вирусологии, 2023
Introduction. Kindia tick virus (KITV) is a novel segmented unclassified flavi-like virus of the Flaviviridae family. This virus is associated with ixodes ticks and is potentially pathogenic to humans.
A. A. Gladysheva, A. V. Gladysheva, V. A. Ternovoi, V. B. Loktev   +3 more
doaj   +1 more source

Human Respiratory Syncytial Virus NS2 Protein Induces Autophagy by Modulating Beclin1 Protein Stabilization and ISGylation

mBio, 2022
Paramyxoviruses such as respiratory syncytial virus (RSV) are the leading cause of pneumonia in infants, the elderly, and immunocompromised individuals.
Kim Chiok, Swechha M. Pokharel, Indira Mohanty, Lindsay Grace Miller, Shou-Jiang Gao, Arthur L. Haas, Kim C. Tran, Michael N. Teng, Santanu Bose   +8 more
doaj   +1 more source

Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation

Viruses, 2022
Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans.
Anastasia Latanova, Elizaveta Starodubova, Vadim Karpov   +2 more
doaj   +1 more source

Experimental Dengue Virus Type 4 Infection Increases the Expression of MicroRNAs-15/16, Triggering a Caspase-Induced Apoptosis Pathway

Current Issues in Molecular Biology, 2023
The World Health Organization has estimated the annual occurrence of approximately 392 million dengue virus (DENV) infections in more than 100 countries where the virus is endemic, which represents a serious threat to humanity.
Samir Mansour Moraes Casseb, Karla Fabiane Lopes de Melo, Carlos Alberto Marques de Carvalho, Carolina Ramos dos Santos, Edna Cristina Santos Franco, Pedro Fernando da Costa Vasconcelos   +5 more
doaj   +1 more source