Results 1 to 10 of about 47,745 (223)

Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles

mBio, 2021
The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus replication
Christopher H. Lee, Krishnan Raghunathan, Gwen M. Taylor, Andrea J. French, Raquel Tenorio, Isabel Fernández de Castro, Cristina Risco, John S. L. Parker, Terence S. Dermody   +8 more
doaj   +4 more sources

Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins

Membranes, 2022
Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins.
Qingxin Li, Congbao Kang
doaj   +3 more sources

Annexin A2 stabilizes the endoplasmic reticulum and actin cytoskeleton and influences the formation of reovirus factories [PDF]

Journal of Virology
Early in infection, mammalian orthoreoviruses (reoviruses) build neo-organelles called viral factories (VFs). These structures incorporate fragments of endoplasmic reticulum (ER) and serve as sites of viral genome replication and particle assembly.
Raquel Tenorio, Gwen M. Taylor, Ana Cayuela, C. O. S. Sorzano, Isabel Fernández de Castro, Sara Y. Fernández-Sánchez, Alexa N. Roth, Xayathed Somoulay, Gavin S. Treadaway, Terence S. Dermody, Cristina Risco   +10 more
doaj   +2 more sources

Nonstructural protein NS80 is crucial in recruiting viral components to form aquareoviral factories. [PDF]

PLoS ONE, 2013
BACKGROUND: Replication and assembly of vertebrate reoviruses occur in specific intracellular compartments known as viral factories. Recently, NS88 and NS80, the nonstructural proteins from aquareoviruses, have been proposed to share common traits with ...
Fei Ke, Li-Bo He, Qi-Ya Zhang
doaj   +4 more sources

Proviral NUP153 binding to viral proteins and RNA regulates structural–nonstructural protein ratios in orthoflavivirus infection [PDF]

Nature Communications
Orthoflaviviruses are RNA viruses that cause serious diseases in humans, with currently no antivirals available. Targeting host factors is emerging as an attractive antiviral approach.
Marie B. A. Peters, Richard Lindqvist, Eszter Kassa, Wai-Lok Yau, Pallabi Sengupta, Isabell Niedermoser, Gisa Gerold, Nasim Sabouri, Ylva Ivarsson, Richard Lundmark, Anna K. Överby   +10 more
doaj   +2 more sources

Zika virus and host protein interactions for understanding molecular mechanisms of pathogenesis and therapeutic development [PDF]

Frontiers in Cellular and Infection Microbiology
Zika virus (ZIKV) causes severe neurological disease, including microcephaly and Guillain-Barré syndrome, through complex interactions with host cell proteins.
Xiaodong Han, Jiansen Du, Wenhui Li, Shuqian Yang, Huamuzi Sun, Guihua Wang, Haolong Cong   +6 more
doaj   +2 more sources

Potential Phosphorylation of Viral Nonstructural Protein 1 in Dengue Virus Infection [PDF]

Viruses, 2021
Dengue virus (DENV) infection causes a spectrum of dengue diseases that have unclear underlying mechanisms. Nonstructural protein 1 (NS1) is a multifunctional protein of DENV that is involved in DENV infection and dengue pathogenesis. This study investigated the potential post-translational modification of DENV NS1 by phosphorylation following DENV ...
Thanyaporn Dechtawewat, Sittiruk Roytrakul, Yodying Yingchutrakul, Sawanya Charoenlappanit, Bunpote Siridechadilok, Thawornchai Limjindaporn, Arunothai Mangkang, Tanapan Prommool, Chunya Puttikhunt, Pucharee Songprakhon, Kessiri Kongmanas, Nuttapong Kaewjew, Panisadee Avirutnan, Pa-thai Yenchitsomanus, Prida Malasit, Sansanee Noisakran   +15 more
openaire   +3 more sources

Peptides targeting dengue viral nonstructural protein 1 inhibit dengue virus production [PDF]

Scientific Reports, 2020
AbstractViruses manipulate the life cycle in host cells via the use of viral properties and host machineries. Development of antiviral peptides against dengue virus (DENV) infection has previously been concentrated on blocking the actions of viral structural proteins and enzymes in virus entry and viral RNA processing in host cells.
Pucharee Songprakhon, Thanawat Thaingtamtanha, Thawornchai Limjindaporn, Chunya Puttikhunt, Chatchawan Srisawat, Prasit Luangaram, Thanyaporn Dechtawewat, Chairat Uthaipibull, Sissades Thongsima, Pa‐thai Yenchitsomanus, Prida Malasit, Sansanee Noisakran   +11 more
openaire   +2 more sources

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis [PDF]

Cell Host & Microbe, 2019
Murine norovirus (MNoV) infects a low percentage of enteric tuft cells and can persist in these cells for months following acute infection. Both tuft-cell tropism and resistance to interferon-λ (IFN-λ)-mediated clearance during persistent infection requires the viral nonstructural protein 1/2 (NS1/2).
Sanghyun, Lee, Hejun, Liu, Craig B, Wilen, Zoi E, Sychev, Chandni, Desai, Barry L, Hykes, Robert C, Orchard, Broc T, McCune, Ki-Wook, Kim, Timothy J, Nice, Scott A, Handley, Megan T, Baldridge, Gaya K, Amarasinghe, Herbert W, Virgin   +13 more
openaire   +2 more sources

Rotavirus Nonstructural Protein NSP3 Is Not Required for Viral Protein Synthesis [PDF]

Journal of Virology, 2006
ABSTRACT Initiation is the rate-limiting step in protein synthesis and therefore an important target for regulation. For the initiation of translation of most cellular mRNAs, the cap structure at the 5′ end is bound by the translation factor eukaryotic initiation factor 4E (eIF4E), while the poly(A) tail, at the 3′ end, is recognized by the ...
Hilda, Montero, Carlos F, Arias, Susana, Lopez   +2 more
openaire   +2 more sources