Results 1 to 10 of about 35,514 (220)

Nonstructural protein NS80 is crucial in recruiting viral components to form aquareoviral factories. [PDF]

PLoS ONE, 2013
BACKGROUND: Replication and assembly of vertebrate reoviruses occur in specific intracellular compartments known as viral factories. Recently, NS88 and NS80, the nonstructural proteins from aquareoviruses, have been proposed to share common traits with ...
Fei Ke, Li-Bo He, Qi-Ya Zhang
doaj   +8 more sources

Structures and Dynamics of Dengue Virus Nonstructural Membrane Proteins

Membranes, 2022
Dengue virus is an important human pathogen threating people, especially in tropical and sub-tropical regions. The viral genome has one open reading frame and encodes one polyprotein which can be processed into structural and nonstructural (NS) proteins.
Qingxin Li, Congbao Kang
doaj   +4 more sources

Proviral NUP153 binding to viral proteins and RNA regulates structural–nonstructural protein ratios in orthoflavivirus infection [PDF]

Nature Communications
Orthoflaviviruses are RNA viruses that cause serious diseases in humans, with currently no antivirals available. Targeting host factors is emerging as an attractive antiviral approach.
Marie B. A. Peters, Richard Lindqvist, Eszter Kassa, Wai-Lok Yau, Pallabi Sengupta, Isabell Niedermoser, Gisa Gerold, Nasim Sabouri, Ylva Ivarsson, Richard Lundmark, Anna K. Överby   +10 more
doaj   +4 more sources

Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles

mBio, 2021
The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus replication
Christopher H. Lee, Krishnan Raghunathan, Gwen M. Taylor, Andrea J. French, Raquel Tenorio, Isabel Fernández de Castro, Cristina Risco, John S. L. Parker, Terence S. Dermody   +8 more
doaj   +4 more sources

Annexin A2 stabilizes the endoplasmic reticulum and actin cytoskeleton and influences the formation of reovirus factories [PDF]

Journal of Virology
Early in infection, mammalian orthoreoviruses (reoviruses) build neo-organelles called viral factories (VFs). These structures incorporate fragments of endoplasmic reticulum (ER) and serve as sites of viral genome replication and particle assembly.
Raquel Tenorio, Gwen M. Taylor, Ana Cayuela, C. O. S. Sorzano, Isabel Fernández de Castro, Sara Y. Fernández-Sánchez, Alexa N. Roth, Xayathed Somoulay, Gavin S. Treadaway, Terence S. Dermody, Cristina Risco   +10 more
doaj   +2 more sources

The Expression and Function of the Small Nonstructural Proteins of Adeno-Associated Viruses (AAVs)

Viruses
Adeno-associated viruses (AAVs) are small, non-enveloped viruses that package a single-stranded (ss)DNA genome of 4.7 kilobases (kb) within their T = 1 icosahedral capsid.
Cagla Aksu Kuz, Shane McFarlin, Jianming Qiu   +2 more
doaj   +2 more sources

Flaviviridae Nonstructural Proteins: The Role in Molecular Mechanisms of Triggering Inflammation

Viruses, 2022
Members of the Flaviviridae family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans.
Anastasia Latanova, Elizaveta Starodubova, Vadim Karpov   +2 more
doaj   +2 more sources

Functional analysis of viral nonstructural and structural proteins [PDF]

, 1989
The genera Alphavirus and Flavivirus contain enveloped RNA viruses which are similar in size, morphology, and RNA content, and were once considered to belong to the same family, the Togaviridae. Recently the flaviviruses were reclassified as a separate family, the Flaviviridae, because they differ markedly from alphaviruses in replication strategy and ...
Hahn, Young Shin Lim
openaire   +2 more sources

Zika virus and host protein interactions for understanding molecular mechanisms of pathogenesis and therapeutic development [PDF]

Frontiers in Cellular and Infection Microbiology
Zika virus (ZIKV) causes severe neurological disease, including microcephaly and Guillain-Barré syndrome, through complex interactions with host cell proteins.
Xiaodong Han, Jiansen Du, Wenhui Li, Shuqian Yang, Huamuzi Sun, Guihua Wang, Haolong Cong   +6 more
doaj   +2 more sources

Structural analysis of the flexibility of the Ubl2 domain within the papain-like protease of SARS-CoV-2. [PDF]

Acta Crystallogr F Struct Biol Commun
The ubiquitin‐like domain 2 (Ubl2) of the SARS‐CoV‐2 virus is necessary for the stability and catalytic efficiency of its papain‐like protease (PLpro). Our crystallographic study reveals that the Ubl2 domain exhibits notable flexibility and can adopt a conformation that places itself away from the PLpro catalytic domain, representing a new conformation
Freiherr von Scholley GL, Schaefer M, Tully MD, Hograindleur MA, Soler-López M, Hillig RC, Mueller-Dieckmann C, Kandiah E.   +7 more
europepmc   +2 more sources