Results 1 to 10 of about 18,162 (217)

Activated Ras Signaling Pathways and Reovirus Oncolysis: An Update on the Mechanism of Preferential Reovirus Replication in Cancer Cells [PDF]

Frontiers in Oncology, 2014
The development of wild-type, unmodified Type 3 Dearing (T3D) strain reovirus as an anticancer agent has currently expanded to 32 clinical trials (both completed and ongoing) involving reovirus in the treatment of cancer.
Jun Gong, Gong Jun
exaly   +4 more sources

Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants [PDF]

Viruses, 2015
Viruses that specifically replicate in tumor over normal cells offer promising cancer therapies. Oncolytic viruses (OV) not only kill the tumor cells directly; they also promote anti-tumor immunotherapeutic responses.
Randal Johnston, Maya Shmulevitz, Adil Mohamed   +2 more
exaly   +4 more sources

Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy [PDF]

Journal for ImmunoTherapy of Cancer, 2022
Background Many solid tumors do not respond to immunotherapy due to their immunologically cold tumor microenvironment (TME). We and others found that oncolytic viruses (OVs), including reovirus type 3 Dearing, can enhance the efficacy of immunotherapy by
Rob C Hoeben, Sjoerd H van der Burg, Marjolein Sluijter, Thorbald van Hall, Joke M M Den Haan, Camilla Labrie, Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Nadine van Montfoort, Lisa Griffioen, Jordi J C van Stigt Thans   +11 more
doaj   +3 more sources

Oncolytic reovirus in canine mast cell tumor. [PDF]

PLoS ONE, 2013
The usage of reovirus has reached phase II and III clinical trials in human cancers. However, this is the first study to report the oncolytic effects of reovirus in veterinary oncology, focusing on canine mast cell tumor (MCT), the most common cutaneous ...
Chung Chew Hwang, Saori Umeki, Masahito Kubo, Toshiharu Hayashi, Hiroshi Shimoda, Masami Mochizuki, Ken Maeda, Kenji Baba, Hiroko Hiraoka, Matt Coffey, Masaru Okuda, Takuya Mizuno   +11 more
doaj   +3 more sources

Activation of p53 by chemotherapeutic agents enhances reovirus oncolysis. [PDF]

PLoS ONE, 2013
Mammalian reovirus is a benign virus that possesses the natural ability to preferentially infect and kill cancer cells (reovirus oncolysis). Reovirus exploits aberrant Ras signalling in many human cancers to promote its own replication and spread.
Da Pan, Paola Marcato, Dae-Gyun Ahn, Shashi Gujar, Lu-Zhe Pan, Maya Shmulevitz, Patrick W K Lee   +6 more
doaj   +3 more sources

Ataxin-2-like promotes translation of nonpolyadenylated reovirus mRNA [PDF]

Nature Communications
Mammalian orthoreovirus (reovirus) nonstructural protein μNS nucleates viral factories (VFs), which are sites of viral genome replication, protein synthesis, and particle assembly.
Xayathed Somoulay, Gavin S. Treadaway, Stefanie Hedayati, Myles E. Steed, Nathan E. Adam, Monico S. Williams, John S. L. Parker, John L. Woolford, Laurie A. Silva, Gwen M. Taylor, Terence S. Dermody   +10 more
doaj   +2 more sources

Reovirus resistance in tumors mediated by elevated ISG expression: overcoming therapeutic resistance via JAK/STAT pathway modulation [PDF]

Virology Journal
Background Oncolytic viruses such as reovirus hold significant promise for cancer therapy, but their efficacy varies across tumor types due to heterogeneous tumor cell sensitivity to reovirus.
Yuxin Yang, Xiaojin Lin, Liang Chen, Yuting Fan, Xiaowei Dou, Jing Zhang, Yingchun Zhang, Dan Liang, Xing Zhao   +8 more
doaj   +2 more sources

Single versus repeated intravenous oncolytic reovirus infusions: Implications for immune modulation and rationalised scheduling of therapy in hepatocellular carcinoma. [PDF]

Int J Cancer
What's new? Oncolytic viruses are a promising immunotherapeutic approach against many malignancies. However, it is unclear whether repeated doses have improved therapeutic value or may trigger greater side effects, especially in patients with hepatocellular carcinoma whose liver is chronically damaged.
Scott KJ, West EJ, Brownlie RJ, Ismail F, Ralph C, Heineman T, Coffey M, Melcher AA, Taylor A, Papa S, Samson A.   +10 more
europepmc   +2 more sources

Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus

Nature Communications, 2023
Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and disseminates systemically to cause serotype-specific patterns of disease in the brain.
Pengcheng Shang, Joshua D. Simpson, Gwen M. Taylor, Danica M. Sutherland, Olivia L. Welsh, Pavithra Aravamudhan, Rita Dos Santos Natividade, Kristina Schwab, Joshua J. Michel, Amanda C. Poholek, Yijen Wu, Dhivyaa Rajasundaram, Melanie Koehler, David Alsteens, Terence S. Dermody   +14 more
doaj   +1 more source

Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality

Frontiers in Immunology, 2023
In recent years, reoviruses have been of major interest in immunotherapy because of their oncolytic properties. Preclinical and clinical trials, in which reovirus was used for the treatment of melanoma and glioblastoma, have paved the way for future ...
Raghad Khaleafi, Jelena Zeleznjak, Sapir Cordela, Shani Drucker, Tihana Lenac Rovis, Stipan Jonjic, Yotam Bar-On   +6 more
doaj   +1 more source