Results 1 to 10 of about 27,138 (209)

Ataxin-2-like promotes translation of nonpolyadenylated reovirus mRNA [PDF]

Nature Communications
Mammalian orthoreovirus (reovirus) nonstructural protein μNS nucleates viral factories (VFs), which are sites of viral genome replication, protein synthesis, and particle assembly.
Xayathed Somoulay, Gavin S. Treadaway, Stefanie Hedayati, Myles E. Steed, Nathan E. Adam, Monico S. Williams, John S. L. Parker, John L. Woolford, Laurie A. Silva, Gwen M. Taylor, Terence S. Dermody   +10 more
doaj   +2 more sources

Reovirus resistance in tumors mediated by elevated ISG expression: overcoming therapeutic resistance via JAK/STAT pathway modulation [PDF]

Virology Journal
Background Oncolytic viruses such as reovirus hold significant promise for cancer therapy, but their efficacy varies across tumor types due to heterogeneous tumor cell sensitivity to reovirus.
Yuxin Yang, Xiaojin Lin, Liang Chen, Yuting Fan, Xiaowei Dou, Jing Zhang, Yingchun Zhang, Dan Liang, Xing Zhao   +8 more
doaj   +2 more sources

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer. [PDF]

MedComm (2020)
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Jin S, Zhang Y, Zhou Z, Zhang Y, Yu T, Xu R, Xu L, Zhang J, Zhang L, Yang S, Wang X.   +10 more
europepmc   +2 more sources

Modulating autophagy in KRAS mutant colorectal cancer using combination of oncolytic reovirus and carbamazepine. [PDF]

PLoS ONE
Oncolytic reovirus is a potential therapeutic for colorectal cancer patients with a mutant KRAS gene. Reovirus hijacks the autophagic machinery and preferentially induces apoptosis in patients with a KRAS mutation.
Aaron Shaykevich, Danbee Chae, Isaac Silverman, Sanjay Goel, Radhashree Maitra   +4 more
doaj   +2 more sources

Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus

Nature Communications, 2023
Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and disseminates systemically to cause serotype-specific patterns of disease in the brain.
Pengcheng Shang, Joshua D. Simpson, Gwen M. Taylor, Danica M. Sutherland, Olivia L. Welsh, Pavithra Aravamudhan, Rita Dos Santos Natividade, Kristina Schwab, Joshua J. Michel, Amanda C. Poholek, Yijen Wu, Dhivyaa Rajasundaram, Melanie Koehler, David Alsteens, Terence S. Dermody   +14 more
doaj   +1 more source

Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy

Journal for ImmunoTherapy of Cancer, 2022
Background Many solid tumors do not respond to immunotherapy due to their immunologically cold tumor microenvironment (TME). We and others found that oncolytic viruses (OVs), including reovirus type 3 Dearing, can enhance the efficacy of immunotherapy by
Rob C Hoeben, Sjoerd H van der Burg, Marjolein Sluijter, Thorbald van Hall, Joke M M Den Haan, Camilla Labrie, Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Nadine van Montfoort, Lisa Griffioen, Jordi J C van Stigt Thans   +11 more
doaj   +1 more source

Activation of p53 by chemotherapeutic agents enhances reovirus oncolysis. [PDF]

PLoS ONE, 2013
Mammalian reovirus is a benign virus that possesses the natural ability to preferentially infect and kill cancer cells (reovirus oncolysis). Reovirus exploits aberrant Ras signalling in many human cancers to promote its own replication and spread.
Da Pan, Paola Marcato, Dae-Gyun Ahn, Shashi Gujar, Lu-Zhe Pan, Maya Shmulevitz, Patrick W K Lee   +6 more
doaj   +1 more source

Oncolytic reovirus in canine mast cell tumor. [PDF]

PLoS ONE, 2013
The usage of reovirus has reached phase II and III clinical trials in human cancers. However, this is the first study to report the oncolytic effects of reovirus in veterinary oncology, focusing on canine mast cell tumor (MCT), the most common cutaneous ...
Chung Chew Hwang, Saori Umeki, Masahito Kubo, Toshiharu Hayashi, Hiroshi Shimoda, Masami Mochizuki, Ken Maeda, Kenji Baba, Hiroko Hiraoka, Matt Coffey, Masaru Okuda, Takuya Mizuno   +11 more
doaj   +1 more source

Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality

Frontiers in Immunology, 2023
In recent years, reoviruses have been of major interest in immunotherapy because of their oncolytic properties. Preclinical and clinical trials, in which reovirus was used for the treatment of melanoma and glioblastoma, have paved the way for future ...
Raghad Khaleafi, Jelena Zeleznjak, Sapir Cordela, Shani Drucker, Tihana Lenac Rovis, Stipan Jonjic, Yotam Bar-On   +6 more
doaj   +1 more source

Reovirus Low-Density Particles Package Cellular RNA

Viruses, 2021
Packaging of segmented, double-stranded RNA viral genomes requires coordination of viral proteins and RNA segments. For mammalian orthoreovirus (reovirus), evidence suggests either all ten or zero viral RNA segments are simultaneously packaged in a ...
Timothy W. Thoner, Xiang Ye, John Karijolich, Kristen M. Ogden   +3 more
doaj   +1 more source