Results 21 to 30 of about 15,096 (180)

Noncoding RNA Profile in Reovirus Treated KRAS-Mutated Colorectal Cancer Patients

Diseases, 2023
Purpose: To investigate the alterations in the expression of noncoding, micro, and small RNA expression during treatment with oncolytic reovirus in KRAS-mutated colorectal cancer. Methods: Oncolytic reovirus treatment was administered in phase 1 clinical
Rafael Saperstein, Sanjay Goel, Radhashree Maitra   +2 more
doaj   +1 more source

CONGENITAL INFECTIONS WITH REOVIRUS [PDF]

The Journal of Experimental Medicine, 1966
Congenital reovirus, type 2 infections were produced after intraperitoneal inoculations of brood mothers on the 1st, 3rd, 6th, 10th, and 15th day of gestation. The offspring presented with a varied syndrome. About a quarter of a total of over 200 mice showed symptoms within the first 14 days of life; namely, lassitude, retarded growth, and roughening ...
A, Hahimi, M M, Carruthers, P, Wolf, A M, Lerner   +3 more
openaire   +2 more sources

Reovirus Receptors and Pathogenesis [PDF]

Journal of Virology, 2003
Mammalian reoviruses are nonenveloped viruses that contain a segmented double-stranded RNA genome. Most mammalian species, including humans, serve as hosts for reovirus infection, but reovirus-induced disease is restricted to the very young (reviewed in reference [61][1]).
J Craig, Forrest, Terence S, Dermody
openaire   +2 more sources

Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain.

PLoS Pathogens, 2008
Apoptosis plays an important role in the pathogenesis of reovirus encephalitis. Reovirus outer-capsid protein mu1, which functions to penetrate host cell membranes during viral entry, is the primary regulator of apoptosis following reovirus infection ...
Pranav Danthi, Caroline M Coffey, John S L Parker, Ty W Abel, Terence S Dermody   +4 more
doaj   +1 more source

Origin of Reovirus Oligo(A) [PDF]

Journal of Virology, 1974
Reovirus contains about 1,200 molecules per virion of oligo(A) of chain length 10 to 15 nucleotides in addition to the 10 double-stranded genome segments. Virions purified from infected BHK, HeLa, or L cells had similar amounts of oligo(A) of the same composition, indicating that it is a virus-specific product.
C, Carter, C M, Stoltzfus, A K, Banerjee, A J, Shatkin   +3 more
openaire   +2 more sources

Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons.

PLoS Pathogens, 2020
Several barriers protect the central nervous system (CNS) from pathogen invasion. Yet viral infections of the CNS are common and often debilitating. Understanding how neurotropic viruses co-opt host machinery to overcome challenges to neuronal entry and ...
Pavithra Aravamudhan, Krishnan Raghunathan, Jennifer Konopka-Anstadt, Amrita Pathak, Danica M Sutherland, Bruce D Carter, Terence S Dermody   +6 more
doaj   +1 more source

Reovirus infection induces stabilization and up-regulation of cellular transcripts that encode regulators of TGF-β signaling. [PDF]

PLoS ONE, 2018
Reovirus infection induces dramatic changes in host mRNA expression. We utilized oligonucleotide microarrays to measure cellular mRNA decay rates in mock- or reovirus-infected murine L929 cells to determine if changes in host mRNA expression are a ...
Liang Guo, Jennifer A Smith, Michelle Abelson, Irina Vlasova-St Louis, Leslie A Schiff, Paul R Bohjanen   +5 more
doaj   +1 more source

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis

PLoS Pathogens, 2022
Cholesterol homeostasis is required for the replication of many viruses, including Ebola virus, hepatitis C virus, and human immunodeficiency virus-1. Niemann-Pick C1 (NPC1) is an endosomal-lysosomal membrane protein involved in cholesterol trafficking ...
Paula Ortega-Gonzalez, Gwen Taylor, Rohit K. Jangra, Raquel Tenorio, Isabel Fernandez de Castro, Bernardo A. Mainou, Robert C. Orchard, Craig B. Wilen, Pamela H. Brigleb, Jorna Sojati, Kartik Chandran, Martin Sachse, Cristina Risco, Terence S. Dermody   +13 more
doaj   +2 more sources

Oncolytic Reovirus Infection Is Facilitated by the Autophagic Machinery

Viruses, 2017
Mammalian reovirus is a double-stranded RNA virus that selectively infects and lyses transformed cells, making it an attractive oncolytic agent. Despite clinical evidence for anti-tumor activity, its efficacy as a stand-alone therapy remains to be ...
Vera Kemp, Iris J. C. Dautzenberg, Ronald W. Limpens, Diana J. M. van den Wollenberg, Rob C. Hoeben   +4 more
doaj   +1 more source

The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism

Molecular Therapy: Oncolytics, 2020
Reovirus type 3 Dearing (reovirus) is a tumor-selective oncolytic virus currently under evaluation in clinical trials. Here, we report that the therapeutic efficacy of reovirus in head and neck squamous cell cancer can be enhanced by targeting the ...
Martin McLaughlin, Malin Pedersen, Victoria Roulstone, Katharina F. Bergerhoff, Henry G. Smith, Harriet Whittock, Joan N. Kyula, Magnus T. Dillon, Hardev S. Pandha, Richard Vile, Alan A. Melcher, Kevin J. Harrington   +11 more
doaj   +1 more source