Results 21 to 30 of about 19,955 (213)

Myosin-9 is required for lysosome-mediated nonlytic reovirus egress. [PDF]

PLoS Pathog
Mammalian orthoreoviruses (reoviruses) are nonenveloped, double-stranded RNA viruses that assemble progeny particles in cytoplasmic viral factories (VFs) and exit some types of cells using a nonlytic release mechanism.
Fernández de Castro I, Sachse M, Taylor GM, Fernández JJ, Tenorio R, Fernández-Sánchez SY, Dermody TS, Risco C.   +7 more
europepmc   +2 more sources

Immune mediated and direct killing of colorectal cancer by reovirus [PDF]

, 2012
Colorectal cancer remains the second most prevalent cancer in the world. Novel treatment strategies are necessary, especially for the treatment of metastatic disease.
Adair, Robert Allan
core   +6 more sources

Paired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus

Nature Communications, 2023
Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and disseminates systemically to cause serotype-specific patterns of disease in the brain.
Pengcheng Shang, Joshua D. Simpson, Gwen M. Taylor, Danica M. Sutherland, Olivia L. Welsh, Pavithra Aravamudhan, Rita Dos Santos Natividade, Kristina Schwab, Joshua J. Michel, Amanda C. Poholek, Yijen Wu, Dhivyaa Rajasundaram, Melanie Koehler, David Alsteens, Terence S. Dermody   +14 more
doaj   +1 more source

Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality

Frontiers in Immunology, 2023
In recent years, reoviruses have been of major interest in immunotherapy because of their oncolytic properties. Preclinical and clinical trials, in which reovirus was used for the treatment of melanoma and glioblastoma, have paved the way for future ...
Raghad Khaleafi, Jelena Zeleznjak, Sapir Cordela, Shani Drucker, Tihana Lenac Rovis, Stipan Jonjic, Yotam Bar-On   +6 more
doaj   +1 more source

Modulation of Reoviral Cytolysis (I): Combination Therapeutics

Viruses, 2023
Patients with stage IV gastric cancer suffer from dismal outcomes, a challenge especially in many Asian populations and for which new therapeutic options are needed.
Yoshinori Mori, Sandra G. Nishikawa, Andreea R. Fratiloiu, Mio Tsutsui, Hiromi Kataoka, Takashi Joh, Randal N. Johnston   +6 more
doaj   +1 more source

PUMA and NF-kB Are Cell Signaling Predictors of Reovirus Oncolysis of Breast Cancer. [PDF]

PLoS ONE, 2017
Reovirus is a ubiquitous RNA virus that exploits aberrant signaling pathways for its replication. The oncolytic potential of reovirus against numerous cancers under pre-clinical/clinical conditions has been documented by us and others. Despite its proven
Chandini Thirukkumaran, Zhong-Qiao Shi, Ponnampalam Thirukkumaran, Joanne Luider, Karen Kopciuk, Jason Spurrell, Kate Elzinga, Don Morris   +7 more
doaj   +1 more source

Reovirus-induced cell-mediated immunity for the treatment of multiple myeloma within the resistant bone marrow niche

Journal for ImmunoTherapy of Cancer, 2021
Background Multiple myeloma (MM) remains an incurable disease and oncolytic viruses offer a well-tolerated addition to the therapeutic arsenal. Oncolytic reovirus has progressed to phase I clinical trials and its direct lytic potential has been ...
Victoria Jennings, Christopher Parrish, Christy Ralph, Alan Melcher, Adel Samson, Gordon Cook, Fiona Errington-Mais, Matt Coffey, Munitta Muthana, Gemma Migneco, Louise M E Müller, Gina B Scott, Jenny Down, Sancha King, Basem Askar, Babatunde Oyajobi, Karen Scott, Emma West, Elizabeth J Ilett, Michelle Lawson   +19 more
doaj   +1 more source

Cytokine-induced killer cell delivery enhances the antitumor activity of oncolytic reovirus. [PDF]

PLoS ONE, 2017
Oncolytic viruses (OV) have recently emerged as a promising therapeutic modality in cancer treatment. OV selectively infect and kill tumor cells, while sparing untransformed cells.
Xing Zhao, Weiwei Ouyang, Cariad Chester, Shiqi Long, Nianxue Wang, Zhixu He   +5 more
doaj   +1 more source

Defective Virions of Reovirus [PDF]

Journal of Virology, 1970
When purified preparations of stock reovirus, type 3, were digested with chymotrypsin, the virions were converted into two different types of particle. These new particles could be separated from each other by isopycnic centrifugation in cesium chloride gradients. One particle banded at a buoyant density of 1.43 g/cm 3
M, Nonoyama, Y, Watanabe, A F, Graham
openaire   +2 more sources

Glycan Engagement Dictates Hydrocephalus Induction by Serotype 1 Reovirus

mBio, 2015
Receptors expressed on the host cell surface adhere viruses to target cells and serve as determinants of viral tropism. Several viruses bind cell surface glycans to facilitate entry, but the contribution of specific glycan moieties to viral disease is ...
Jennifer Stencel-Baerenwald, Kerstin Reiss, Bärbel S. Blaum, Daniel Colvin, Xiao-Nan Li, Ty Abel, Kelli Boyd, Thilo Stehle, Terence S. Dermody   +8 more
doaj   +1 more source