Modulation of Reoviral Cytolysis (I): Combination Therapeutics
Viruses, 2023 Patients with stage IV gastric cancer suffer from dismal outcomes, a challenge especially in many Asian populations and for which new therapeutic options are needed.
Yoshinori Mori +6 more
doaj +1 more source
PUMA and NF-kB Are Cell Signaling Predictors of Reovirus Oncolysis of Breast Cancer. [PDF]
PLoS ONE, 2017 Reovirus is a ubiquitous RNA virus that exploits aberrant signaling pathways for its replication. The oncolytic potential of reovirus against numerous cancers under pre-clinical/clinical conditions has been documented by us and others. Despite its proven
Chandini Thirukkumaran +7 more
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Viral RNA at two stages of reovirus infection is required for the induction of necroptosis [PDF]
, 2017 Necroptosis, a regulated form of necrotic cell death, requires the activation of the RIP3 kinase. Here, we identify that infection of host cells with reovirus can result in necroptosis.
Berger, Angela K +6 more
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Interferon-lambda: A potent regulator of intestinal viral infections [PDF]
, 2017 Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and ...
Baldridge, Megan T, Lee, Sanghyun
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Cytokine-induced killer cell delivery enhances the antitumor activity of oncolytic reovirus. [PDF]
PLoS ONE, 2017 Oncolytic viruses (OV) have recently emerged as a promising therapeutic modality in cancer treatment. OV selectively infect and kill tumor cells, while sparing untransformed cells.
Xing Zhao +5 more
doaj +1 more source
Mortality associated with avian reovirus infection in a free-living magpie (Pica pica) in Great Britain [PDF]
, 2015 Avian reoviruses (ARVs) cause a range of disease presentations in domestic, captive and free-living bird species. ARVs have been reported as a cause of significant disease and mortality in free-living corvid species in North America and continental ...
Cunningham, AA +9 more
core +1 more source
Journal for ImmunoTherapy of Cancer, 2021 Background Multiple myeloma (MM) remains an incurable disease and oncolytic viruses offer a well-tolerated addition to the therapeutic arsenal. Oncolytic reovirus has progressed to phase I clinical trials and its direct lytic potential has been ...
Victoria Jennings +19 more
doaj +1 more source
The role of cellular adhesion molecules in virus attachment and entry [PDF]
, 2015 As obligate intracellular parasites, viruses must traverse the host-cell plasma membrane to initiate infection. This presents a formidable barrier, which they have evolved diverse strategies to overcome.
Bhella, David
core +1 more source
Frontiers in Oncology, 2014 The development of wild-type, unmodified Type 3 Dearing (T3D) strain reovirus as an anticancer agent has currently expanded to 32 clinical trials (both completed and ongoing) involving reovirus in the treatment of cancer.
Jun eGong, Monica Mirela Mita
doaj +1 more source
Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of IFN-lambda against norovirus and reovirus [PDF]
, 2017 Lambda interferon (IFN-λ) has potent antiviral effects against multiple enteric viral pathogens, including norovirus and rotavirus, in both preventing and curing infection. Because the intestine includes a diverse array of cell types, however, the cell(s)
Baldridge, Megan T +7 more
core +2 more sources