Results 11 to 20 of about 18,162 (217)
Reovirus Low-Density Particles Package Cellular RNA [PDF]
Viruses, 2021 Packaging of segmented, double-stranded RNA viral genomes requires coordination of viral proteins and RNA segments. For mammalian orthoreovirus (reovirus), evidence suggests either all ten or zero viral RNA segments are simultaneously packaged in a ...
Timothy W. Thoner +3 more
doaj +2 more sources
Bid regulates the pathogenesis of neurotropic reovirus. [PDF]
PLoS Pathogens, 2010 Reovirus infection leads to apoptosis in both cultured cells and the murine central nervous system (CNS). NF-kappaB-driven transcription of proapoptotic cellular genes is required for the effector phase of the apoptotic response.
Pranav Danthi +5 more
doaj +2 more sources
Reovirus infection in the pigeon. [PDF]
Annales de recherches veterinaires. Annals of veterinary research, 1982 The pigeon is sisceptible to Reovirus infection since a strain has been isolated from a sick pigeon and 8p. cent of pigeons selected at random in Belgium possess specific antibodies. The strain of Reovirus isolated does not seem to be highly pathogenic for the pigeon as experimental inoculation resulted in the appearance of no symptoms except for ...
Vindevogel, Henri +4 more
openaire +5 more sources
Myosin-9 is required for lysosome-mediated nonlytic reovirus egress. [PDF]
PLoS PathogMammalian orthoreoviruses (reoviruses) are nonenveloped, double-stranded RNA viruses that assemble progeny particles in cytoplasmic viral factories (VFs) and exit some types of cells using a nonlytic release mechanism.
Fernández de Castro I +7 more
europepmc +2 more sources
Modulation of Reoviral Cytolysis (I): Combination Therapeutics
Viruses, 2023 Patients with stage IV gastric cancer suffer from dismal outcomes, a challenge especially in many Asian populations and for which new therapeutic options are needed.
Yoshinori Mori +6 more
doaj +1 more source
PUMA and NF-kB Are Cell Signaling Predictors of Reovirus Oncolysis of Breast Cancer. [PDF]
PLoS ONE, 2017 Reovirus is a ubiquitous RNA virus that exploits aberrant signaling pathways for its replication. The oncolytic potential of reovirus against numerous cancers under pre-clinical/clinical conditions has been documented by us and others. Despite its proven
Chandini Thirukkumaran +7 more
doaj +1 more source
Mutagenic specificity in reovirus [PDF]
Journal of Virology, 1979 Mutagenic specificity in response to chemical mutagens has been observed with certain temperature-sensitive mutants of reovirus type 3. One mutant induced by nitrous acid reverted specifically with nitrous acid. Three nitrosoguanidine-induced mutants reverted after nitrous acid treatment.
U R, Ray, B N, Fields
openaire +2 more sources
Journal for ImmunoTherapy of Cancer, 2021 Background Multiple myeloma (MM) remains an incurable disease and oncolytic viruses offer a well-tolerated addition to the therapeutic arsenal. Oncolytic reovirus has progressed to phase I clinical trials and its direct lytic potential has been ...
Victoria Jennings +19 more
doaj +1 more source
Cytokine-induced killer cell delivery enhances the antitumor activity of oncolytic reovirus. [PDF]
PLoS ONE, 2017 Oncolytic viruses (OV) have recently emerged as a promising therapeutic modality in cancer treatment. OV selectively infect and kill tumor cells, while sparing untransformed cells.
Xing Zhao +5 more
doaj +1 more source