Results 11 to 20 of about 19,955 (213)
Viruses, 2015 Viruses that specifically replicate in tumor over normal cells offer promising cancer therapies. Oncolytic viruses (OV) not only kill the tumor cells directly; they also promote anti-tumor immunotherapeutic responses.
Randal Johnston +2 more
exaly +4 more sources
Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy [PDF]
Journal for ImmunoTherapy of Cancer, 2022 Background Many solid tumors do not respond to immunotherapy due to their immunologically cold tumor microenvironment (TME). We and others found that oncolytic viruses (OVs), including reovirus type 3 Dearing, can enhance the efficacy of immunotherapy by
Rob C Hoeben +11 more
doaj +2 more sources
Oncolytic reovirus in canine mast cell tumor. [PDF]
PLoS ONE, 2013 The usage of reovirus has reached phase II and III clinical trials in human cancers. However, this is the first study to report the oncolytic effects of reovirus in veterinary oncology, focusing on canine mast cell tumor (MCT), the most common cutaneous ...
Chung Chew Hwang +11 more
doaj +2 more sources
Reovirus Low-Density Particles Package Cellular RNA
Viruses, 2021 Packaging of segmented, double-stranded RNA viral genomes requires coordination of viral proteins and RNA segments. For mammalian orthoreovirus (reovirus), evidence suggests either all ten or zero viral RNA segments are simultaneously packaged in a ...
Timothy W. Thoner +3 more
doaj +2 more sources
Activation of p53 by chemotherapeutic agents enhances reovirus oncolysis. [PDF]
PLoS ONE, 2013 Mammalian reovirus is a benign virus that possesses the natural ability to preferentially infect and kill cancer cells (reovirus oncolysis). Reovirus exploits aberrant Ras signalling in many human cancers to promote its own replication and spread.
Da Pan +6 more
doaj +2 more sources
A Bayesian Model for Estimation of Virus Reduction in Potable Reuse Treatment Trains and Quantitative Microbial Risk Assessment of Waterborne Viral Pathogens [PDF]
Risk Analysis, Volume 46, Issue 9, September 2026.ABSTRACT Understanding virus occurrence and reduction at advanced treatment facilities for potable water reuse constitutes a high‐priority research need to protect human health and to enhance available water supply alternatives. The objectives were to (1) determine log reduction values (LRVs) of 15 viruses by advanced wastewater treatment; (2) evaluate
Jack F. Schijven +2 more
wiley +2 more sources
Activated Ras signaling pathways and reovirus oncolysis: an update on the mechanism of preferential reovirus replication in cancer cells [PDF]
Frontiers in Oncology, 2014 The development of wild-type, unmodified Type 3 Dearing (T3D) strain reovirus as an anticancer agent has currently expanded to 32 clinical trials (both completed and ongoing) involving reovirus in the treatment of cancer.
Jun eGong, Monica Mirela Mita
doaj +2 more sources
Reovirus: Friend and Foe [PDF]
Current Clinical Microbiology Reports, 2019 Mammalian orthoreovirus (reovirus) is a powerful tool for studying viral replication and pathogenesis. Most reovirus infections are subclinical, however recent work has catapulted reovirus into the clinical spotlight.Owing to its capacity to kill cancer cells more efficiently than normal cells, reovirus is under development as a therapeutic for a ...
Karl Boehme
exaly +3 more sources
Ataxin-2-like promotes translation of nonpolyadenylated reovirus mRNA [PDF]
Nature CommunicationsMammalian orthoreovirus (reovirus) nonstructural protein μNS nucleates viral factories (VFs), which are sites of viral genome replication, protein synthesis, and particle assembly.
Xayathed Somoulay +10 more
doaj +2 more sources
Bid regulates the pathogenesis of neurotropic reovirus.
PLoS Pathogens, 2010 Reovirus infection leads to apoptosis in both cultured cells and the murine central nervous system (CNS). NF-kappaB-driven transcription of proapoptotic cellular genes is required for the effector phase of the apoptotic response.
Pranav Danthi +5 more
doaj +2 more sources