Results 31 to 40 of about 27,138 (209)
Comparisons of Celiac Disease and Non-Celiac Gluten Sensitivity [PDF]
, 2020 Celiac disease (CD) and non-celiac gluten sensitivity (NCGS) are often confused or grouped together due to their commonalities. However, this is careless behavior because there are clinically significant differences between the two diseases. Similarities
Thomas, Victoria
core +1 more source
Primed for Discovery: Atomic-Resolution Cryo-EM Structure of a Reovirus Entry Intermediate [PDF]
, 2010 A recently solved structure of the aquareovirus virion (Zhang, X; Jin, L.; Fang, Q; Hui, W.H.; Zhou Z.H. 3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry.
John T. Patton +2 more
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CONGENITAL INFECTIONS WITH REOVIRUS [PDF]
The Journal of Experimental Medicine, 1966 Congenital reovirus, type 2 infections were produced after intraperitoneal inoculations of brood mothers on the 1st, 3rd, 6th, 10th, and 15th day of gestation. The offspring presented with a varied syndrome. About a quarter of a total of over 200 mice showed symptoms within the first 14 days of life; namely, lassitude, retarded growth, and roughening ...
A, Hahimi +3 more
openaire +2 more sources
Molecular Therapy: Oncolytics, 2019 Oncolytic virotherapy using reovirus is a promising new anti-cancer treatment with potential for use in humans and dogs. Because reovirus monotherapy shows limited efficacy in human and canine cancer patients, the clinical development of a combination ...
Masaya Igase +8 more
doaj +1 more source
Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons.
PLoS Pathogens, 2020 Several barriers protect the central nervous system (CNS) from pathogen invasion. Yet viral infections of the CNS are common and often debilitating. Understanding how neurotropic viruses co-opt host machinery to overcome challenges to neuronal entry and ...
Pavithra Aravamudhan +6 more
doaj +1 more source
Reovirus infection induces stabilization and up-regulation of cellular transcripts that encode regulators of TGF-β signaling. [PDF]
PLoS ONE, 2018 Reovirus infection induces dramatic changes in host mRNA expression. We utilized oligonucleotide microarrays to measure cellular mRNA decay rates in mock- or reovirus-infected murine L929 cells to determine if changes in host mRNA expression are a ...
Liang Guo +5 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2020 Reovirus type 3 Dearing (reovirus) is a tumor-selective oncolytic virus currently under evaluation in clinical trials. Here, we report that the therapeutic efficacy of reovirus in head and neck squamous cell cancer can be enhanced by targeting the ...
Martin McLaughlin +11 more
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Cancer Cell International, 2021 Background and aims Several oncolytic viruses applications have been approved in the clinic or in different phases of clinical trials. However, these methods have some rudimentary problems.
Seyed-Mahmood Seyed-Khorrami +3 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2021 Background Oncolytic viruses reduce tumor burden in animal models and have generated promising results in clinical trials. However, it is likely that oncolytic viruses will be more effective when used in combination with other therapies.
Simon Gebremeskel +6 more
doaj +1 more source
A putative ATPase mediates RNA transcription and capping in a dsRNA virus. [PDF]
, 2015 mRNA transcription in dsRNA viruses is a highly regulated process but the mechanism of this regulation is not known. Here, by nucleoside triphosphatase (NTPase) assay and comparisons of six high-resolution (2.9-3.1 Å) cryo-electron microscopy structures ...
Jiang, Jiansen +3 more
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