Results 31 to 40 of about 15,096 (180)

Systemically Administered Reovirus-Induced Downregulation of Hypoxia Inducible Factor-1α in Subcutaneous Tumors

Molecular Therapy: Oncolytics, 2019
Reovirus, which possesses a 10-segmented double-stranded RNA genome, mediates superior antitumor effects via not only virus replication in a tumor cell-specific manner but also other mechanisms distinct from virus replication.
Takuma Hotani, Hiroyuki Mizuguchi, Fuminori Sakurai   +2 more
doaj   +1 more source

Natural killer T cell immunotherapy combined with oncolytic vesicular stomatitis virus or reovirus treatments differentially increases survival in mouse models of ovarian and breast cancer metastasis

Journal for ImmunoTherapy of Cancer, 2021
Background Oncolytic viruses reduce tumor burden in animal models and have generated promising results in clinical trials. However, it is likely that oncolytic viruses will be more effective when used in combination with other therapies.
Simon Gebremeskel, Adam Nelson, Brynn Walker, Tora Oliphant, Lynnea Lobert, Douglas Mahoney, Brent Johnston   +6 more
doaj   +1 more source

Combination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma

Molecular Therapy: Oncolytics, 2019
Oncolytic virotherapy using reovirus is a promising new anti-cancer treatment with potential for use in humans and dogs. Because reovirus monotherapy shows limited efficacy in human and canine cancer patients, the clinical development of a combination ...
Masaya Igase, Shusaku Shibutani, Yosuke Kurogouchi, Noriyuki Fujiki, Chung Chew Hwang, Matt Coffey, Shunsuke Noguchi, Yuki Nemoto, Takuya Mizuno   +8 more
doaj   +1 more source

Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy

Journal for ImmunoTherapy of Cancer, 2020
Background T-cell-engaging CD3-bispecific antibodies (CD3-bsAbs) are promising modalities for cancer immunotherapy. Although this therapy has reached clinical practice for hematological malignancies, the absence of sufficient infiltrating T cells is a ...
Rob C Hoeben, Sjoerd H van der Burg, Thorbald van Hall, Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Ruben L van den Oever, Jim Middelburg, Dana A M Mustafa, Nadine van Montfoort   +9 more
doaj   +1 more source

MSCs loaded with oncolytic reovirus: migration and in vivo virus delivery potential for evaluating anti-cancer effect in tumor-bearing C57BL/6 mice

Cancer Cell International, 2021
Background and aims Several oncolytic viruses applications have been approved in the clinic or in different phases of clinical trials. However, these methods have some rudimentary problems.
Seyed-Mahmood Seyed-Khorrami, Hoorieh Soleimanjahi, Sara Soudi, Ala Habibian   +3 more
doaj   +1 more source

Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles

mBio, 2021
The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus replication
Christopher H. Lee, Krishnan Raghunathan, Gwen M. Taylor, Andrea J. French, Raquel Tenorio, Isabel Fernández de Castro, Cristina Risco, John S. L. Parker, Terence S. Dermody   +8 more
doaj   +1 more source

Bacteria and bacterial envelope components enhance mammalian reovirus thermostability.

PLoS Pathogens, 2017
Enteric viruses encounter diverse environments as they migrate through the gastrointestinal tract to infect their hosts. The interaction of eukaryotic viruses with members of the host microbiota can greatly impact various aspects of virus biology ...
Angela K Berger, Hong Yi, Daniel B Kearns, Bernardo A Mainou   +3 more
doaj   +1 more source

Reovirus Receptors and Apoptosis

Virology, 2001
The mammalian reoviruses are a tractable experimental system for studies of viral replication and pathogenesis. Reovirus virions are nonenveloped, double-shelled particles containing a genome of 10 segments of doublestranded RNA (Nibert and Schiff, 2001).
Barton, Erik S., Chappell, James D., Connolly, Jodi L., Forrest, J.Craig, Dermody, Terence S.   +4 more
openaire   +2 more sources

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source