Results 31 to 40 of about 19,955 (213)
Noncoding RNA Profile in Reovirus Treated KRAS-Mutated Colorectal Cancer Patients
Diseases, 2023 Purpose: To investigate the alterations in the expression of noncoding, micro, and small RNA expression during treatment with oncolytic reovirus in KRAS-mutated colorectal cancer. Methods: Oncolytic reovirus treatment was administered in phase 1 clinical
Rafael Saperstein +2 more
doaj +1 more source
Mortality associated with avian reovirus infection in a free-living magpie (Pica pica) in Great Britain [PDF]
, 2015 Avian reoviruses (ARVs) cause a range of disease presentations in domestic, captive and free-living bird species. ARVs have been reported as a cause of significant disease and mortality in free-living corvid species in North America and continental ...
Pocknell, A +19 more
core +1 more source
Mutagenic specificity in reovirus [PDF]
Journal of Virology, 1979 Mutagenic specificity in response to chemical mutagens has been observed with certain temperature-sensitive mutants of reovirus type 3. One mutant induced by nitrous acid reverted specifically with nitrous acid. Three nitrosoguanidine-induced mutants reverted after nitrous acid treatment.
U R, Ray, B N, Fields
openaire +2 more sources
Oncolytic Reovirus Infection Is Facilitated by the Autophagic Machinery
Viruses, 2017 Mammalian reovirus is a double-stranded RNA virus that selectively infects and lyses transformed cells, making it an attractive oncolytic agent. Despite clinical evidence for anti-tumor activity, its efficacy as a stand-alone therapy remains to be ...
Vera Kemp +4 more
doaj +1 more source
Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain.
PLoS Pathogens, 2008 Apoptosis plays an important role in the pathogenesis of reovirus encephalitis. Reovirus outer-capsid protein mu1, which functions to penetrate host cell membranes during viral entry, is the primary regulator of apoptosis following reovirus infection ...
Pranav Danthi +4 more
doaj +1 more source
Reovirus infection induces stabilization and up-regulation of cellular transcripts that encode regulators of TGF-β signaling. [PDF]
PLoS ONE, 2018 Reovirus infection induces dramatic changes in host mRNA expression. We utilized oligonucleotide microarrays to measure cellular mRNA decay rates in mock- or reovirus-infected murine L929 cells to determine if changes in host mRNA expression are a ...
Liang Guo +5 more
doaj +1 more source
Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons.
PLoS Pathogens, 2020 Several barriers protect the central nervous system (CNS) from pathogen invasion. Yet viral infections of the CNS are common and often debilitating. Understanding how neurotropic viruses co-opt host machinery to overcome challenges to neuronal entry and ...
Pavithra Aravamudhan +6 more
doaj +1 more source
Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis
PLoS Pathogens, 2022 Cholesterol homeostasis is required for the replication of many viruses, including Ebola virus, hepatitis C virus, and human immunodeficiency virus-1. Niemann-Pick C1 (NPC1) is an endosomal-lysosomal membrane protein involved in cholesterol trafficking ...
Paula Ortega-Gonzalez +13 more
doaj +2 more sources
Molecular Therapy: Oncolytics, 2019 Reovirus, which possesses a 10-segmented double-stranded RNA genome, mediates superior antitumor effects via not only virus replication in a tumor cell-specific manner but also other mechanisms distinct from virus replication.
Takuma Hotani +2 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2020 Reovirus type 3 Dearing (reovirus) is a tumor-selective oncolytic virus currently under evaluation in clinical trials. Here, we report that the therapeutic efficacy of reovirus in head and neck squamous cell cancer can be enhanced by targeting the ...
Martin McLaughlin +11 more
doaj +1 more source