Results 31 to 40 of about 18,162 (217)

Reovirus uses macropinocytosis-mediated entry and fast axonal transport to infect neurons.

PLoS Pathogens, 2020
Several barriers protect the central nervous system (CNS) from pathogen invasion. Yet viral infections of the CNS are common and often debilitating. Understanding how neurotropic viruses co-opt host machinery to overcome challenges to neuronal entry and ...
Pavithra Aravamudhan, Krishnan Raghunathan, Jennifer Konopka-Anstadt, Amrita Pathak, Danica M Sutherland, Bruce D Carter, Terence S Dermody   +6 more
doaj   +1 more source

Reovirus infection induces stabilization and up-regulation of cellular transcripts that encode regulators of TGF-β signaling. [PDF]

PLoS ONE, 2018
Reovirus infection induces dramatic changes in host mRNA expression. We utilized oligonucleotide microarrays to measure cellular mRNA decay rates in mock- or reovirus-infected murine L929 cells to determine if changes in host mRNA expression are a ...
Liang Guo, Jennifer A Smith, Michelle Abelson, Irina Vlasova-St Louis, Leslie A Schiff, Paul R Bohjanen   +5 more
doaj   +1 more source

Reovirus type 1 associated with meningitis [PDF]

, 1996
A previously healthy 3-month-old girl presented with symptoms of meningitis, diarrhoea, vomiting and fever. Green monkey kidney (GMK) cells inoculated with cerebrospinal fluid (CSF) revealed reovirus-like particles by electron microscopy.
Svensson, Lennart, Johansson, Hugo, Sveger, Tomas, Ekstrand, Jarl, Ahlfors, Karin   +4 more
core   +3 more sources

Oncolytic Reovirus Infection Is Facilitated by the Autophagic Machinery

Viruses, 2017
Mammalian reovirus is a double-stranded RNA virus that selectively infects and lyses transformed cells, making it an attractive oncolytic agent. Despite clinical evidence for anti-tumor activity, its efficacy as a stand-alone therapy remains to be ...
Vera Kemp, Iris J. C. Dautzenberg, Ronald W. Limpens, Diana J. M. van den Wollenberg, Rob C. Hoeben   +4 more
doaj   +1 more source

The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism

Molecular Therapy: Oncolytics, 2020
Reovirus type 3 Dearing (reovirus) is a tumor-selective oncolytic virus currently under evaluation in clinical trials. Here, we report that the therapeutic efficacy of reovirus in head and neck squamous cell cancer can be enhanced by targeting the ...
Martin McLaughlin, Malin Pedersen, Victoria Roulstone, Katharina F. Bergerhoff, Henry G. Smith, Harriet Whittock, Joan N. Kyula, Magnus T. Dillon, Hardev S. Pandha, Richard Vile, Alan A. Melcher, Kevin J. Harrington   +11 more
doaj   +1 more source

MSCs loaded with oncolytic reovirus: migration and in vivo virus delivery potential for evaluating anti-cancer effect in tumor-bearing C57BL/6 mice

Cancer Cell International, 2021
Background and aims Several oncolytic viruses applications have been approved in the clinic or in different phases of clinical trials. However, these methods have some rudimentary problems.
Seyed-Mahmood Seyed-Khorrami, Hoorieh Soleimanjahi, Sara Soudi, Ala Habibian   +3 more
doaj   +1 more source

Natural killer T cell immunotherapy combined with oncolytic vesicular stomatitis virus or reovirus treatments differentially increases survival in mouse models of ovarian and breast cancer metastasis

Journal for ImmunoTherapy of Cancer, 2021
Background Oncolytic viruses reduce tumor burden in animal models and have generated promising results in clinical trials. However, it is likely that oncolytic viruses will be more effective when used in combination with other therapies.
Simon Gebremeskel, Adam Nelson, Brynn Walker, Tora Oliphant, Lynnea Lobert, Douglas Mahoney, Brent Johnston   +6 more
doaj   +1 more source

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis

PLoS Pathogens, 2022
Cholesterol homeostasis is required for the replication of many viruses, including Ebola virus, hepatitis C virus, and human immunodeficiency virus-1. Niemann-Pick C1 (NPC1) is an endosomal-lysosomal membrane protein involved in cholesterol trafficking ...
Paula Ortega-Gonzalez, Gwen Taylor, Rohit K. Jangra, Raquel Tenorio, Isabel Fernandez de Castro, Bernardo A. Mainou, Robert C. Orchard, Craig B. Wilen, Pamela H. Brigleb, Jorna Sojati, Kartik Chandran, Martin Sachse, Cristina Risco, Terence S. Dermody   +13 more
doaj   +2 more sources

Systemically Administered Reovirus-Induced Downregulation of Hypoxia Inducible Factor-1α in Subcutaneous Tumors

Molecular Therapy: Oncolytics, 2019
Reovirus, which possesses a 10-segmented double-stranded RNA genome, mediates superior antitumor effects via not only virus replication in a tumor cell-specific manner but also other mechanisms distinct from virus replication.
Takuma Hotani, Hiroyuki Mizuguchi, Fuminori Sakurai   +2 more
doaj   +1 more source

Reovirus Nonstructural Protein σNS Recruits Viral RNA to Replication Organelles

mBio, 2021
The function of the mammalian orthoreovirus (reovirus) σNS nonstructural protein is enigmatic. σNS is an RNA-binding protein that forms oligomers and enhances the stability of bound RNAs, but the mechanisms by which it contributes to reovirus replication
Christopher H. Lee, Krishnan Raghunathan, Gwen M. Taylor, Andrea J. French, Raquel Tenorio, Isabel Fernández de Castro, Cristina Risco, John S. L. Parker, Terence S. Dermody   +8 more
doaj   +1 more source